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Application of Shenkang injection in preparing drug for preventing and treating deep vein thrombosis

A technology of Shenkang injection and deep vein, which is used in drug delivery, drug combination, blood diseases, etc., can solve the problem of difficult to grasp the dose

Active Publication Date: 2013-05-15
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vitamin K is also a commonly used preventive drug, but it needs to be taken for enough days, and the dosage is difficult to grasp

Method used

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  • Application of Shenkang injection in preparing drug for preventing and treating deep vein thrombosis
  • Application of Shenkang injection in preparing drug for preventing and treating deep vein thrombosis
  • Application of Shenkang injection in preparing drug for preventing and treating deep vein thrombosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0016] Experimental Example 1 Effect of Shenkang Injection on Hemorheology in Rats with Deep Vein Thrombosis of Lower Extremities

[0017] Experimental materials SD rats, clean grade, 180-220g (Experimental Animal Center of Fourth Military Medical University); ), prothrombin time (PT), partial prothrombin time (APTT) assay kits, provided by Beijing Shidi Scientific Instrument Co., Ltd.

[0018] Experimental method 55 SD rats were fed at room temperature, half male and half male. They were randomly divided into 4 groups, 10 normal group, 15 model group, 15 Shenkang injection prevention group (SKYF group) and 15 Shenkang injection prevention and treatment group (SKYZ group). The normal group and the model group were injected with 1ml / kg normal saline by tail vein every day from 1 week before modeling until the end of the experiment; Until after modeling; the SKYZ group was given daily tail vein injection of Shenkang Injection 2g of crude drug / kg from one week before modeling, ...

experiment example 2

[0033] Experimental exampleEffect of Ershenkang injection on rabbits with lower extremity deep vein thrombosis

[0034] Experimental materials New Zealand white rabbits, half male and half male, were obtained from Xi'an Doumen Experimental Animal Center; SOD and MDA kits were obtained from Nanjing Jiancheng Biotechnology Research Institute.

[0035] Experimental method 46 New Zealand white rabbits, half male and half male, were adaptively fed for 3 days. They were randomly divided into 4 groups, 10 normal group, 12 model group, 12 Shenkang injection prevention group (SKYF group) and 12 Shenkang prevention and treatment group (SKYZ group). Model group, SKYF group and SKYZ group replicated the rabbit lower limb deep vein thrombosis model, the rabbits in each group were anesthetized with 10% urethane 2ml / kg intraperitoneally, fixed the rabbit's back on the rabbit fixer, and cut off the left hind limb The nearby rabbit hair was disinfected, the skin was cut along the femoral vein...

experiment example 3

[0057] Experimental example Sanshenkang injection in the prevention and treatment of lower extremity deep vein thrombosis in major orthopedic surgery

[0058] 149 patients who underwent elective lower limb orthopedic surgery in our hospital included 115 males and 34 females, aged 32-75 years, with an average age of 42±4 years; body weight 40-70kg. They were randomly divided into 4 groups, control group, Shenkang injection (SK) group, Shenkang injection combined with low molecular weight heparin calcium group (combination group) and low molecular weight heparin calcium group. In the control group, there were 10 cases of femoral neck fracture, 12 cases of femoral shaft fracture, 11 cases of femoral shaft fracture, and 3 cases of femoral supracondylar fracture; SK group had 12 cases of femoral neck fracture, 10 cases of femoral trochanter fracture, 13 cases of There were 4 cases of supracondylar fracture; 9 cases of femoral neck fracture, 13 cases of femoral trochanter fracture, ...

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Abstract

The invention discloses application of Shenkang injection or Shenkang injection and an anticoagulant in preparing a drug for preventing and treating deep vein thrombosis caused by orthopaedics major operations. Proved by animal experiments, the Shenkang injection is capable of obviously reducing the whole blood viscosity, the plasma viscosity and the hematokrit of lower-limb deep vein rats and rabbits, obviously prolonging the thrombin time, the prothrombin time and partial thromboplastin time, increasing the content of SOD in blood and reducing the content of MDA, thereby improving the hypercoagulable state of the blood and reducing infiltration of the inflammatory medium; and in addition, the Shenkang injection is capable of obviously reducing the probability of the orthopaedics major operations causing the lower-limb deep vein thrombosis, and enhancing the postoperative immunity.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to application of Shenkang injection or combination of Shenkang injection and anticoagulant in preventing and treating lower extremity deep vein thrombosis caused by major orthopedic surgery. It belongs to the field of medicine. Background technique [0002] Deep Venous Thrombosis (DVT) refers to the abnormal coagulation of blood in deep veins. It is a venous return disorder disease. It mostly occurs in deep veins of lower extremities, and the probability of causing pulmonary thrombosis is relatively high. In traditional Chinese medicine, this disease is considered to belong to the categories of "swelling", "stasis", "blood tumor", "muscle tumor", "evil pulse", "congested blood flow", and "may arthralgia". Modern medicine believes that there are three main factors that cause DVT, including slow venous blood flow, hypercoagulable state of blood, and venous wall damage. [0003] (1) ...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/08A61P7/02
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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