Disodium adenosine triphosphate troche medical composition

A technology of adenosine triphosphate and composition, which is applied in the direction of drug combination, pill delivery, sugar-coated pills, etc., and can solve problems such as increased manufacturing costs, accidental ingestion, and poor operability

Active Publication Date: 2014-09-24
CHENGDU TIANTAISHAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, adenosine triphosphate is unstable to water and easily decomposes. Since the content of active ingredients in the long-term preservation preparation decreases over time, desiccants such as silica gel are used in the storage and transportation stages of medicines, or refrigerated. The use of this additional storage method increases the manufacturing cost associated with the use of desiccants, or there are problems such as poor operability due to refrigeration during distribution
In addition, there are also concerns that consumers may accidentally eat silica gel used as a desiccant

Method used

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  • Disodium adenosine triphosphate troche medical composition
  • Disodium adenosine triphosphate troche medical composition
  • Disodium adenosine triphosphate troche medical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] Embodiment 1: Preparation contains the pharmaceutical composition (tablet) of adenosine triphosphate disodium

[0151] Recipe (amount per tablet):

[0152] Adenosine triphosphate disodium

20mg

[0153] Sodium carboxymethyl starch

5mg

L-Methionine

1mg

Calcium hydrogen phosphate (dihydrate)

150mg

Dextrin

25mg

PEG4000

7

silica

3mg

Magnesium stearate

1mg

[0154] Preparation method: prepare PEG4000 with 70% ethanol to make a 5% solution as a binder, fully mix all materials except silicon dioxide and magnesium stearate, and then use the binder to wet granulate, after drying, the granules are combined with Silicon dioxide and magnesium stearate are evenly mixed, and then compressed into tablets, each containing 20 mg of disodium adenosine triphosphate.

[0155] After measurement, the weight difference of the tablet (plain tablet) is 1.4%, and the friability is reduce...

Embodiment 2

[0158] Embodiment 2: Preparation contains the pharmaceutical composition (tablet) of adenosine triphosphate disodium

[0159] Recipe (amount per tablet):

[0160] Adenosine triphosphate disodium

20mg

Croscarmellose Sodium

5mg

calcium carbonate

120mg

Dextrin

45mg

Polyvinylpyrrolidone

7

Magnesium stearate

3mg

[0161] Preparation method: prepare polyvinylpyrrolidone with 70% ethanol to make a 5% solution as a binder, fully mix all materials except magnesium stearate, and then wet granulate with binder, after drying, the granules are combined with stearin Magnesium Acid is mixed evenly, and then compressed into tablets, each containing 20 mg of adenosine triphosphate disodium.

[0162] It was determined that the weight difference of the tablet (plain tablet) was 2.0%, the friability lost 0.29% in weight, and the residual rate of adenosine triphosphate disodium was 95.5% after being sealed at room temp...

Embodiment 3

[0165] Embodiment 3: Preparation contains the pharmaceutical composition (tablet) of adenosine triphosphate disodium

[0166] Recipe (amount per tablet):

[0167] Adenosine triphosphate disodium

20mg

Low substituted hydroxypropyl cellulose

3.8mg

L-Methionine

1.2mg

Calcium hydrogen phosphate (anhydrous)

100mg

Dextrin

35mg

starch

1mg

silica

3mg

Magnesium stearate

1mg

[0168] Preparation method: adopt the conventional dry granulation and tabletting process, fully mix all materials except silicon dioxide and magnesium stearate, extrude into large tablets with a dry granulator, and then crush them into 16-24 For the purpose granules, silicon dioxide and magnesium stearate are uniformly mixed with the obtained granules, and then compressed into tablets, each containing 20 mg of adenosine triphosphate disodium.

[0169] It was determined that the weight difference of the tablet (pla...

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Abstract

The invention relates to a disodium adenosine triphosphate troche medical composition, and in particular relates to use of calcium salt in preparation of stable triphosadenine or a solid medical composition of officinal salt thereof. The medical composition provided by the invention further stably comprises triphosadenine or the solid medical composition of officinal salt thereof. More specifically, the invention relates to the solid medical composition containing triphosadenine or the officinal salt thereof, wherein even if the medical composition is stored for a long time, the content of the effective components is still highly maintained to ensure the excellent stability. After the solid medical composition provided by the invention is placed at 20+ / -2 DEG C for 2 years, the residual ratio of active components, i.e., triphosadenine or officinal salt thereof in the composition is over 80%.

Description

technical field [0001] The present invention relates to a stable solid pharmaceutical composition containing adenosine triphosphate or a pharmaceutically acceptable salt thereof. More specifically, it relates to a solid pharmaceutical composition containing adenosine triphosphate or a pharmaceutically acceptable salt thereof, which can maintain a high active ingredient content even after long-term storage and has excellent storage stability. Background technique [0002] Adenosine triphosphate, also known as adenosine 5'-triphosphate, is a compound with high-energy phosphate bonds, which releases a large amount of energy when it is hydrolyzed into adenosine 5'-diphosphate and phosphoric acid. In living organisms, in addition to being mainly used as an energy supply source for reactions, adenosine triphosphate also participates in metabolic reactions as a phosphate donor. Adenosine triphosphate commonly used clinically is its disodium salt (CAS 987-65-5), and its structural ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K9/16A61K9/48A61K31/7076A61K47/02A61P25/00A61P9/06A61P27/02A61P1/04A61P21/00
Inventor 赵东明丁多浩吴国庆左伟潘勇董国明
Owner CHENGDU TIANTAISHAN PHARMA
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