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Compound phenol caplets dropping pills and preparation method thereof

A technology of dropping pills and chlorpheniramine acid, which can be used in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as poor stability and low bioavailability

Active Publication Date: 2014-03-19
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings of poor stability and low bioavailability of the existing compound phenol-mamemin preparations, the present invention has invented the compound phenol-mamemin inclusion compound dripping pills

Method used

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  • Compound phenol caplets dropping pills and preparation method thereof
  • Compound phenol caplets dropping pills and preparation method thereof
  • Compound phenol caplets dropping pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The prescription for dropping pills is (by weight):

[0021]

[0022] Preparation:

[0023] 1. According to the following method to prepare the inclusion compound of compound phenamine:

[0024] (1) In water or aqueous ethanol medium, the active ingredients of the drug (by weight ratio, paracetamol: pseudoephedrine hydrochloride: dextromethorphan hydrobromide: chlorpheniramine maleate = 16:1.5 :0.5:0.1) react with hydroxypropyl β-cyclodextrin, filter the resulting solution through a microporous membrane until clarified, and separate the clathrate from the mixture; or

[0025] (2) In solid form, the active ingredient of the drug is reacted with hydroxypropyl β-cyclodextrin; or

[0026] (3) The active ingredient of the drug reacts with hydroxypropyl β-cyclodextrin for high-energy grinding.

[0027] 2. Grind the inclusion compound of compound phenol-mamemin through a 100-200 mesh sieve; grind and mix polyethylene glycol 6000, polyoxyethylene monostearate, dipotassium...

Embodiment 2

[0029] The prescription for dropping pills is (by weight):

[0030]

[0031] The preparation method is the same as in Example 1.

Embodiment 3

[0033] The prescription for dropping pills is (by weight):

[0034]

[0035] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to compound phenol caplets dropping pills and a preparation method thereof. The dropping pills comprise a clathrate of active ingredients, a matrix and a stabilizer, wherein the clathrate of the active ingredients comprises active ingredients and an inclusion material, the active ingredients comprise acetaminophen, pseudoephedrine hydrochloride, dextromethorphan hydrobromide and chlorpheniramine maleate; the weight ratio of acetaminophen to pseudoephedrine hydrochloride to dextromethorphan hydrobromide to chlorpheniramine maleate is 16:1.5:0.5:0.1; the inclusion material comprises alpha-cyclodextrin, beta-cyclodextrin and hydroxy beta-cyclodextrin; the matrix is selected from more than two mixtures of polyethylene glycol 6000, polyethylene glycol 4000, polyoxyethylene monostearate, sodium stearate, glycerogelatin gum, poloxamer, stearic acid and the like. The weight ratio of the active ingredients to the inclusion material is 3:2 to 2:3. The compound phenol caplets dropping pills provided by the invention are good in roundness, rapid in drug dissolution and high in bioavailability.

Description

technical field [0001] The invention discloses a drop pill, in particular to a drop pill containing a compound fen-mamemin inclusion compound and a preparation method thereof. Background technique [0002] Dropping pills have the following characteristics: 1. Simple equipment, convenient operation, beneficial to labor protection, short process cycle and high productivity; 2. Easy to control process conditions, stable quality, accurate dosage, short heating time, easy to oxidize and volatile After the medicine dissolves in the matrix, its stability can be increased; 3, the matrix holds a large amount of liquid medicine, so the liquid medicine can be solidified; 4, the drop pill prepared by solid dispersion technology has the characteristics of rapid absorption and high bioavailability. [0003] The clathrate has the following advantages: mask bad odor and reduce irritation; increase drug dissolution rate and bioavailability; improve drug stability. [0004] The active ingred...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K31/4402A61K31/167A61K31/137A61K9/20A61K47/40A61P29/00A61P11/00
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD