Alfacalcidol sustained-release preparation and preparation method thereof

A technology for alfacalcidol and sustained-release preparations, applied in the field of sustained-release preparations, alfacalcidol sustained-release preparations and their preparations, can solve the problems of inability to achieve long-term, sustained-release administration, and achieve blood drug The effect of small concentration fluctuation, stable release and good sustained release effect

Active Publication Date: 2013-06-05
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing alfacalcidol sustained-release preparations do not release alfacalcidol smoothly and evenly wit

Method used

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  • Alfacalcidol sustained-release preparation and preparation method thereof
  • Alfacalcidol sustained-release preparation and preparation method thereof
  • Alfacalcidol sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0021] Example 1 Preparation of Alfacalcidol Sustained Release Preparation

[0022] Weigh the components according to the following parts by weight:

[0023]

[0024] Mix alfacalcidol, filler, and slow-release matrix methyl cellulose uniformly; add a viscosifier, make soft materials, dry, and granulate; add lubricant, mix uniformly, and press tablets to obtain.

Example Embodiment

[0025] Example 2 Preparation of Alfacalcidol Sustained Release Preparation

[0026] Weigh the components according to the following parts by weight:

[0027]

[0028]

[0029] Mix alfacalcidol, filler and sustained-release matrix hydroxypropylmethyl cellulose uniformly; add viscosifier, make soft material, dry, and granulate; then add lubricant, mix uniformly, and press tablet to get .

Example Embodiment

[0030] Example 3 Preparation of Alfacalcidol Sustained Release Preparation

[0031] Weigh the components according to the following parts by weight:

[0032]

[0033] Alfacalcidol, filler and slow-release matrix polyoxyethylene are mixed uniformly; the viscosifier is added, soft material is made, dried, and granulated; lubricant is added, mixed uniformly, and tablet is obtained.

[0034] Example 3 Preparation of Alfacalcidol Sustained Release Preparation

[0035] Weigh the components according to the following parts by weight:

[0036]

[0037]

[0038] The sustained-release matrix matrix is ​​composed of hydroxypropyl methylcellulose and polyoxyethylene in a weight ratio of 1:1;

[0039] The preparation method is the same as in Example 1.

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Abstract

The invention discloses an alfacalcidol sustained-release preparation and a preparation method thereof. The alfacalcidol sustained release preparation comprises alfacalcidol, a sustained-release skeleton matrix, a filling agent, a surface active agent, a lubricating agent and an adhesive. The alfacalcidol sustained-release preparation can achieve long-acting release, and can stably release effective ingredients in a balanced mode within 24 hours.

Description

technical field [0001] The invention relates to a sustained-release preparation, in particular to an alfacalcidol sustained-release preparation and a preparation method thereof, and belongs to the field of alfacalcidol sustained-release preparations. Background technique [0002] Alfacalcidol regulates the balance of calcium and phosphorus in the body, increases the absorption of calcium and phosphorus in the intestine, reduces the level of parathyroid hormone in plasma, and improves women's menopause and osteoporosis caused by hormone drugs . It is suitable for the prevention and treatment of osteoporosis, nephrogenic bone disease (nephrotic rickets, hyperparathyroidism (with bone disease), hypoparathyroidism, rickets and osteomalacia caused by nutritional and absorption disorders, false Rickets and osteomalacia due to calcium deficiency (D-dependent type I). [0003] The sustained-release preparation can stabilize the blood drug concentration after administration, reduce...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/00A61K31/593A61K47/38A61K47/34A61P3/12A61P3/14A61P19/10
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD
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