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Alfacalcidol sustained-release preparation and preparation method thereof

A technology for alfacalcidol and sustained-release preparations, applied in the field of sustained-release preparations, alfacalcidol sustained-release preparations and their preparations, can solve the problems of inability to achieve long-term, sustained-release administration, and achieve blood drug The effect of small concentration fluctuation, stable release and good sustained release effect

Active Publication Date: 2013-06-05
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing alfacalcidol sustained-release preparations do not release alfacalcidol smoothly and evenly within 24 hours, and cannot achieve the effect of long-term, sustained-release administration, and need to be improved

Method used

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  • Alfacalcidol sustained-release preparation and preparation method thereof
  • Alfacalcidol sustained-release preparation and preparation method thereof
  • Alfacalcidol sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 alfacalcidol sustained-release preparation

[0022] Take each component by the following parts by weight:

[0023]

[0024] Mix alfacalcidol, filling agent and slow-release matrix matrix methyl cellulose uniformly; add binder, make soft material, dry and granulate; add lubricant, mix uniformly, compress into tablets, and obtain.

Embodiment 2

[0025] The preparation of embodiment 2 alfacalcidol sustained-release preparations

[0026] Take each component by the following parts by weight:

[0027]

[0028]

[0029] Mix alfacalcidol, filler and sustained-release matrix matrix hydroxypropyl methylcellulose; add binder, make soft material, dry, and granulate; add lubricant, mix evenly, and compress into tablets to obtain .

Embodiment 3

[0030] The preparation of embodiment 3 alfacalcidol sustained-release preparations

[0031] Take each component by the following parts by weight:

[0032]

[0033] Mix alfacalcidol, filling agent and slow-release matrix matrix polyoxyethylene; add binder, make soft material, dry and granulate;

[0034] The preparation of embodiment 3 alfacalcidol sustained-release preparations

[0035] Take each component by the following parts by weight:

[0036]

[0037]

[0038] The slow-release matrix matrix is ​​composed of hydroxypropylmethylcellulose and polyoxyethylene in a 1:1 weight ratio;

[0039] The preparation method is the same as in Example 1.

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Abstract

The invention discloses an alfacalcidol sustained-release preparation and a preparation method thereof. The alfacalcidol sustained release preparation comprises alfacalcidol, a sustained-release skeleton matrix, a filling agent, a surface active agent, a lubricating agent and an adhesive. The alfacalcidol sustained-release preparation can achieve long-acting release, and can stably release effective ingredients in a balanced mode within 24 hours.

Description

technical field [0001] The invention relates to a sustained-release preparation, in particular to an alfacalcidol sustained-release preparation and a preparation method thereof, and belongs to the field of alfacalcidol sustained-release preparations. Background technique [0002] Alfacalcidol regulates the balance of calcium and phosphorus in the body, increases the absorption of calcium and phosphorus in the intestine, reduces the level of parathyroid hormone in plasma, and improves women's menopause and osteoporosis caused by hormone drugs . It is suitable for the prevention and treatment of osteoporosis, nephrogenic bone disease (nephrotic rickets, hyperparathyroidism (with bone disease), hypoparathyroidism, rickets and osteomalacia caused by nutritional and absorption disorders, false Rickets and osteomalacia due to calcium deficiency (D-dependent type I). [0003] The sustained-release preparation can stabilize the blood drug concentration after administration, reduce...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/00A61K31/593A61K47/38A61K47/34A61P3/12A61P3/14A61P19/10
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD
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