Medicine combination of amantadine/folic acid compounds and purpose thereof
A technology for amantadine and a composition is applied in the field of pharmaceutical compositions of amantadine/folate compounds to achieve the effects of preventing and reducing stroke, overcoming low drug efficacy and increasing curative effect
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Embodiment 1
[0033] Embodiment 1. Preparation of tablet
[0034] prescription:
[0035]
[0036] Preparation Process:
[0037] (1) Take the amantadine and folic acid of the prescribed amount and pass through a 100-mesh sieve and mix them uniformly by the method of equal increments for subsequent use;
[0038] (2) Other auxiliary materials are passed through a 100-mesh sieve and dried at 75°C for 2 hours;
[0039] (3) Mix the starch, microcrystalline cellulose, and CMS.Na according to the prescription amount, and then mix them evenly with the mixed raw material drug in equal increments;
[0040] (4) Add an appropriate amount of binder to prepare soft materials, granulate with a 24-mesh sieve, granulate with a 20-mesh sieve, and dry at 40-75°C.
[0041] (5) Add an appropriate amount of magnesium stearate to the dry granules and mix evenly. After the content is determined, compress into tablets and pack.
[0042] 3 times a day, 1 tablet each time.
Embodiment 2
[0043] Embodiment 2. The preparation of capsule
[0044] prescription:
[0045]
[0046]
[0047] Preparation Process:
[0048] According to the prescription ratio, take lactose, microcrystalline cellulose, starch, and carboxymethyl starch sodium and dry them at about 100°C for about 2 hours, pass through a 100-mesh sieve; pass the raw material through a 100-mesh sieve, and increase the amount of the above-mentioned excipients in equal increments Mix well and fill the capsules.
[0049] 3 times a day, 1 capsule each time.
Embodiment 3
[0050] Example 3. Preparation of Sustained Release Tablets
[0051] prescription:
[0052]
[0053] Preparation Process:
[0054] According to the proportion of the prescription, the raw material is mixed with hypromellose, citric acid is dissolved in ethanol as a wetting agent to make a soft material, granulated, dried, sized, mixed with magnesium stearate, pressed Slice and serve.
[0055] 1 time every other day, 1-2 tablets each time.
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