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Pharmaceutical composition, and preparation method and application thereof

A composition and drug technology, applied in the directions of drug combination, medical formula, plant raw material, etc., can solve the problem of no drug composition being researched, and achieve the effects of enhancing immunity, lowering body immunity, and improving insulin resistance.

Active Publication Date: 2014-02-26
HILL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no suitable pharmaceutical composition has been developed

Method used

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  • Pharmaceutical composition, and preparation method and application thereof
  • Pharmaceutical composition, and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The raw material drug formula is:

[0030] 50g of white grass, 30g of astragalus, 60g of bitter gourd, 30g of Pu'er tea, 10g of dew grass.

[0031] Preparation:

[0032] a. Take the Chinese herbal medicine according to the weight ratio of the crude drug, wash and powder it into powder and pass through a 60-mesh sieve for subsequent use;

[0033] b. Combine white grass, bitter gourd, and Puer tea, add water to decoct twice, add 15 times the amount of water for the first time, decoct for 2 hours, add 8 times the amount of water for the second time, decoct for 1 hour, and combine the decoction , filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.25-1.30 (60°C), dried at 68°C for later use;

[0034] c. Merge astragalus and dew grass, add 15 times the amount of 75% ethanol to soak for 24 hours, extract with 500W ultrasonic wave for 30 minutes, filter, concentrate the filtrate to a thick paste with a relative density of 1.25-1.30 (60°C...

Embodiment 2

[0038] The raw material drug formula is:

[0039] 60g of white grass, 20g of astragalus, 50g of bitter gourd, 40g of Pu'er tea, 10g of dew grass.

[0040] Preparation:

[0041] a. Take the Chinese herbal medicine according to the weight ratio of the crude drug, wash and powder it into powder and pass through a 60-mesh sieve for subsequent use;

[0042] b. Combine white grass, bitter gourd, and Puer tea, add water to decoct twice, add 15 times the amount of water for the first time, decoct for 2 hours, add 8 times the amount of water for the second time, decoct for 1 hour, and combine the decoction , filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.25-1.30 (60°C), dried at 68°C for later use;

[0043] c. Merge astragalus and dew grass, add 15 times the amount of 75% ethanol to soak for 24 hours, extract with 500W ultrasonic wave for 30 minutes, filter, concentrate the filtrate to a thick paste with a relative density of 1.25-1.30 (60°C...

Embodiment 3

[0047] In Vitro Experiment of Improving Insulin Resistance by the Active Ingredients FL1, FL2, FL3 and FL4 of the Pharmaceutical Composition of the Present Invention

[0048] 1. Establishment of 3T3-L1 cell insulin resistance model

[0049]3T3-L1 cells were cultured on a 6-well plate with high-glucose DMEM medium. After the cells reached a certain density, they were replaced with a medium containing a certain concentration of insulin, dexamethasone, and IBMX for value-added culture. After a certain level, the cells were seeded in 24-well plates and cultured with normal medium for 2 days, and resistance was induced after 2 days. The 2 wells were used as blank control, and the rest were cultured with medium containing insulin and dexamethasone. After 5 days of induction, Detect the glucose concentration in the cell culture medium. When the glucose concentration that induces resistance reaches 0.5-1 times the glucose concentration of the blank control, the establishment of resist...

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Abstract

The invention belongs to the technical field of pharmaceutical compositions, and particularly provides a pharmaceutical composition for improving insulin resistance, and a preparation method and application thereof. The pharmaceutical composition is composed of the following crude drugs or extracts in parts by weight: 30-60 parts of herba potentilae, 20-30 parts of radix astragali, 50-60 parts of balsam pear, 20-50 parts of Pu-Erh tea and 10-20 parts of dew grass. The extract is prepared by the following steps: extracting the crude drug with water or alcohol to obtain an extracting solution, concentrating the extracting solution to the relative density of 1.25-1.30, drying, and pulverizing to obtain the extract. The pharmaceutical composition provided by the invention can obviously improve insulin resistance, effectively lowers the blood sugar concentration, and has the advantages of low cost and high use safety.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and mainly relates to a pharmaceutical composition for improving insulin resistance prepared from Chinese herbal medicines. Background technique [0002] Diabetes is a common multiple disease that seriously endangers human health. It is difficult to cure and has extensive and serious complications. It is estimated that by 2025, the number of diabetics in China will reach 36 million, ranking second in the world, and most of them will be aged between 45 and 64. Diabetes can be divided into four types: namely type 1 diabetes, type 2 diabetes, gestational diabetes and specific type of diabetes. Type II diabetes is the result of the joint action of genetic and environmental factors, accounting for more than 90% of the total number of diabetics, more common in overweight or obese middle-aged and elderly people, and has obvious family heredity. [0003] Insulin resistance refers to a phenome...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P3/10
Inventor 周阳峰
Owner HILL PHARMA