Application of porphyrin pigment serving as immunologic adjuvant and vaccine

Abstract

The invention discloses application of a porphyrin pigment serving as immunologic adjuvant and further discloses application of the porphyrin pigment serving as a vaccine. The porphyrin pigment is a biological pigment, tissues outside an animal cardiovascular system can be combined with a pathogeny recognition receptor TLR4, and tissue damage and danger signals are simulated to build efficient stimulation to an immune system. The porphyrin pigment is also an ingredient of an animal and a human body, internal metabolic pathways are clear, uncertainty in the safety aspect does not exist, and the porphyrin pigment is suitable for preparation of the immunologic adjuvant and the vaccine for the animal, especially for human. The porphyrin pigment serving as the immunologic adjuvant can remarkably strengthen the humoral immunity effect of antigen or the vaccine and can reach the level of complete Freund adjuvant.

Description

technical field

[0001] The invention belongs to the field of immunology, and specifically relates to the application of porphyrin pigment as immune adjuvant and vaccine. Background technique

[0002] The problem in modern immunotherapy and immunoprevention is not the immunogenicity of the vaccine itself, but the safety of vaccine preparations (non-polluting factors). Traditional vaccines are low-virulence or inactivated pathogenic microorganisms, which have good immune effects but are highly dangerous; therefore, modern vaccines usually use a certain non-toxic signature component of pathogenic microorganisms or their artificial simulants as antigens, called subunit vaccines or epitope vaccines. Modern vaccines have greatly weakened the immunogenicity while eliminating the danger, and immune adjuvants are needed to make up for the lack of immunogenicity, which has led to the research of modern vaccines essentially becoming the research of immune adjuvants, and at the same ti...

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