Application of diterpenoid compound in treating hepatitis c virus (HCV)

A viral hepatitis and compound technology, applied in the field of natural medicinal chemistry, can solve the problem of no specific drugs for treatment

Inactive Publication Date: 2013-06-12
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Hepatitis C (hepatitisC) was initially defined as non-A non-B hepatitis after blood transfusion. In 1989, its pathogen was isolated and confirmed as hepatitis C virus (HCV, hepatitisCvirus). About 2% of the population in the world is infected by HCV. HCV More than 80% of infected people develop chronic hepatitis, and 20% of them can progress to liver cirrhosis or even liver cancer. Currently, there is no specific drug for anti-HCV treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of diterpenoid compound in treating hepatitis c virus (HCV)
  • Application of diterpenoid compound in treating hepatitis c virus (HCV)
  • Application of diterpenoid compound in treating hepatitis c virus (HCV)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Specific implementation examples

[0020] Extraction and separation of compound 1

[0021] The red fish eye medicinal material (12.5kg) was naturally dried in the shade, crushed to 30 mesh, extracted twice with 75% ethanol under reflux, firstly added 12 times the amount of ethanol, and refluxed for 2 hours; twice, added 8 times the amount of ethanol, refluxed for 1 hour , filter the extract, reduce the alcohol solvent under reduced pressure until the alcohol content of the collected liquid is less than 10%, continue to evaporate and concentrate until there is no alcohol smell (relative density 1.20 / 80°C); add 2 times the amount of water, fully suspend, and use for suspension Petroleum ether is fully extracted until the extract is concentrated, then use vanillin-sulfuric ethanol reagent to check for no reaction, then use ethyl acetate to fully extract until the extract is concentrated, then use vanillin-sulfuric ethanol reagent to check for no reaction, then use n-butano...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an application of a diterpenoid compound in treating hepatitis c virus (HCV) and belongs to the technical field of medicine. The invention discloses the diterpenoid compound with anti-hepatitis c virus (HCV) activity which is extracted and prepared from Phyllanthus reticulatus of Zhuang-medicine Hong Yuyan with Guang xi characteristics. The diterpenoid compound is characterized in that no cytotoxicity exists in a concentration range from 0-3125Mug / rnl, obvious inhibitory effects (p<0.05-p<0.01) over the HCV replicon ribonucleic acid (RNA) exist in a concentration range from 125 mu g / rnl-15625Mug / rnl. The diterpenoid compound (II) has a wide market future in the new medicine development of anti- hepatitis c virus (HCV).

Description

technical field [0001] The present invention relates to the field of natural medicinal chemistry. Specifically, it relates to a preparation method of diterpene compound (II) and its application in anti-hepatitis C virus (HCV). Background technique [0002] Hepatitis C (hepatitisC) was initially defined as non-A non-B hepatitis after blood transfusion. In 1989, its pathogen was isolated and confirmed as hepatitis C virus (HCV, hepatitisCvirus). About 2% of the population in the world is infected by HCV. HCV More than 80% of infected people develop into chronic hepatitis, and 20% of them can develop into liver cirrhosis or even liver cancer. However, there is no specific drug for anti-HCV treatment at present. Therefore, it is of great practical significance to search for new anti-HCV drugs or lead compounds from traditional Chinese medicine, plants and fungi resources. Phyllanthus retIIculatus, a specialty Zhuang medicine in Guangxi, is a plant of the genus Phyllanthus retI...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P31/14A61P1/16C07H1/08C07H15/18
Inventor 蓝鸣生谭昌恒马健雄陈路宋志军朱大元
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap