Aromatic amino acid polymer

A polymer, amino acid technology, applied in the field of aromatic amino acid polymers, can solve the problems of preparation, structure and performance, and achieve the effects of wide application value, good degradability, and excellent biocompatibility

A polymer, amino acid technology, applied in the field of aromatic amino acid polymers, can solve the problems of preparation, structure and performance, and achieve the effects of wide application value, good degradability, and excellent biocompatibility

CN103159944AInactive Publication Date: 2013-06-19JIANGNAN UNIV
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  • Aromatic amino acid polymer
  • Aromatic amino acid polymer
  • Aromatic amino acid polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Step 1: Add 5.916 g (30 mmol) of L-dopa to NaHCO under stirring in an ice bath 3 (7.5wt%) in the aqueous solution; Di-tert-butyl dicarbonate ((Boc) 2 O) 7.857g (36mmol) was dissolved in 50ml 1,4-dioxane, dropped into the reaction system, reacted at 5°C for 30min, then raised the temperature to 25°C under stirring, and reacted for 19.5h; the whole reaction process was carried out under nitrogen and Carry out under dark conditions. After the reaction, adjust the pH of the solution to 2-3 with 1M HCl, then extract with ethyl acetate (100ml×3); add an appropriate amount of anhydrous MgSO 4 After drying, a light yellow oil was obtained, which was L-dopa protected by tert-butoxycarbonyl.

[0020] The second step: 2.98g (10mmol) of L-dopa protected by tert-butoxycarbonyl group, 0.009g (0.1mmol) of sodium acetate, and 15ml of acetic anhydride were added to a 100ml reactor, and the temperature was raised to 140°C. After 1 hour of reaction, the temperature was raised again To ...

Embodiment 2

[0025] Add 5.430g (30mmol) of L-tyrosine to NaHCO 3 (7.5wt%) in the aqueous solution; Di-tert-butyl dicarbonate ((Boc) 2 O) 7.857g (36mmol) was dissolved in 50ml 1,4-dioxane, and other steps were carried out as described in Example 1. The molecular formula of the obtained homopolymer is:

[0026]

[0027] Expressed as PTyr.

Embodiment 3

[0029] Add 5.430 g (30 mmol) of 2-hydroxyphenylalanine to NaHCO 3 (7.5wt%) in the aqueous solution; Di-tert-butyl dicarbonate ((Boc) 2 O) 7.857g (36mmol) was dissolved in 50ml 1,4-dioxane, and other steps were carried out as described in Example 1. The molecular formula of the obtained homopolymer is:

[0030]

[0031] Expressed as P2HPA.

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Abstract

The invention provides an aromatic amino acid polymer which is prepared by using aromatic ring-containing amino acids such as L-beta-p-hydroxybenzoate alanine (L-tyrosine, Tyr), 2-hydroxyphenylalanine (2HPA), L-3,4-dihydroxyphenylalanine (dopa, L-DOPA ) and the like as monomers, protecting the amino, performing fusion polycondensation, and then de-protecting under an acidic condition to obtain the finish product. The polymer provided by the invention is quite good in degradability and biocompatibility, and can be used as degradable materials for organization engineering materials, package materials, environmentally friendly cleaning agents, detergents and other fields, and also for adsorption of inorganic particles.

Description

technical field [0001] The invention relates to an aromatic ring amino acid polymer, which belongs to the field of functional polymer materials. Background technique [0002] Based on the effective utilization of resources and the protection of the environment, scientific researchers have gradually shifted their research on polymer materials from petroleum resources to biomass resources. Biomass resources can be extracted from natural animals and plants. New organic polymers synthesized from biomass monomers generally have good properties, such as degradability and biocompatibility, and most of them can be degraded into carbon dioxide and carbon dioxide in nature. Water can realize the recycling of raw materials. In addition, biomass monomers generally have multifunctional groups, which can flexibly design the molecular structure of polymers through polymerization reactions to realize the functionalization of polymer materials. [0003] The monomers used in the present inv...

Claims

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Application Information

Patent Timeline
19 Jun 2013
Publication
CN103159944A
IPC
C08G63/685
Inventors
施冬健; 孔蕊