Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Butylphthalide controlled release preparation and preparation method thereof

A technology of controlled-release preparation and butylphthalide, which is applied in the field of butylphthalide preparations, can solve the problems of large amount of hydrophilic gel skeleton material, large amount of cyclodextrin, unable to meet the requirements of sustained-release tablets, etc.

Active Publication Date: 2013-06-26
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
View PDF8 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 200710062273.9, the invention uses cyclodextrin and its derivatives in combination with an emulsifier, and the amount of cyclodextrin is relatively large. The inventor also used the same amount of cyclodextrin and Its derivatives, but found: the release rate of the sustained-release tablets made is higher, the dissolution rate is faster, and a large amount of hydrophilic gel skeleton material is required, which cannot meet the requirements of the sustained-release tablets. Therefore, the present invention selects and limits less The β-cyclodextrin with the lower solubility of the amount can better meet the needs of the present invention

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Butylphthalide controlled release preparation and preparation method thereof
  • Butylphthalide controlled release preparation and preparation method thereof
  • Butylphthalide controlled release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, The liquid medicine contains an emulsifier, but the middle layer does not contain an emulsifier.

[0056] .

[0057] Preparation Process:

[0058] ① Preparation of gelatin solution: take gelatin and add appropriate amount of water to make it absorb water and swell. In addition, heat glycerin, ethylparaben and the remaining water in a colloidal sol pot to 70~80°C, mix well, add expanded gelatin, stir, melt, keep warm for 1~2 hours, let stand to make the foam float up, scrape off The floating foam is filtered with a clean white cloth and kept warm for later use. The viscosity of the formulated glue is generally 2.8~3.2 degrees;

[0059] ②Preparation of liquid medicine oil: weigh the components and stir well to get it;

[0060] ③ Pressing soft capsules: Put the prepared gelatin liquid and butylphthalide into the automatic rotary encapsulating machine, control the temperature at 40~50°C, and press out soft capsules;

[0061] ④ Preparation of the middl...

Embodiment 2

[0068] Embodiment 2, Both the liquid medicine and the intermediate layer contain emulsifiers.

[0069] Preparation process steps: ①~③, ⑤~⑩ are the same as in Example 1; ④ Preparation of intermediate layer solution: Dissolve mannitol, ethoxylated polyoxyethylene glyceride and povidone in ethanol.

Embodiment 3

[0070] Embodiment 3, According to the second method of dissolution determination (paddle method) of appendix XC of the Chinese Pharmacopoeia 2010 edition, with pH6.8 phosphate buffer as the dissolution medium, measure Examples 1 and 2, and draw the release curve, the results are shown in the appendix figure 2 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a butylphthalide controlled release preparation and a preparation method thereof. Drugs can be uniformly released at a constant speed, and release of liquid drugs from the controlled release preparation in a liquid form is achieved.

Description

technical field [0001] The invention relates to a butylphthalide preparation, in particular to a controlled-release preparation of butylphthalide and a preparation method thereof. Background technique [0002] Racemic butylphthalide (dl-3-n-butylphthalide), and its two enantiomers: D-butylphthalide (d-3-n-butylphthalide) and L-butylphthalide (l-3-n -butylphthalide), are water-insoluble volatile oils. [0003] Clinically, butylphthalide is mainly used in the treatment of mild and moderate acute ischemic stroke, and it also has a good effect on the symptoms of cerebrovascular diseases such as angioneurotic headache, hypertension, chronic headache caused by arteriosclerosis, and stroke headache. Preventive and therapeutic effects. L-Butylphthalide, which was developed later, also has similar medical effects. [0004] Because the volatile oil is easy to volatilize at room temperature, it is easy to volatilize and lose during the conventional preparation process, so it is diff...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/66A61K31/365A61P9/10A61P9/12
Inventor 张志宏梁敏王世霞王悦辛伟白英
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com