Biocompatible fiber composite non-woven net felt and preparation method and application thereof

A fiber composite and biocompatible technology, which is applied in textiles and papermaking, human tubular structure devices, blood vessels, etc., can solve the problems of regenerative stenosis, affecting the patency rate of blood vessels, and reducing the patency rate of vascular grafts. simple effect

Active Publication Date: 2013-06-26
广州帷幄生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the above-mentioned solutions still have deficiencies: Although surgical repair of diseased blood vessels is more thorough, it is traumatic and risky; patients undergoing stent implantation have a certain probability of post-stent restenosis six months later, The probability of thick blood vessels is about 20%, and the probability of thin blood vessels can reach 33%. With the passage of time, the patency rate of the original blood vessels will be greatly reduced. The patency rate of blood vessels is only 50%; while the artificial blood vessels made of existing materials are used for replacement grafting or bypass grafting, the patency rate of vascular grafts is even l

Method used

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  • Biocompatible fiber composite non-woven net felt and preparation method and application thereof
  • Biocompatible fiber composite non-woven net felt and preparation method and application thereof
  • Biocompatible fiber composite non-woven net felt and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0082] Polyurethane (PU) was dissolved in hexafluoroisopropanol at a ratio of 12 wt%, and polycaprolactone (PCL) was dissolved in a 3:1 mixture of dichloromethane / dimethylformamide at a ratio of 25 wt%. in solvent. In order to visually distinguish fibers of two different materials, a fluorescent carbocyanine dye was added to the polyurethane solution, and a green fluorescent dye was added to the polycaprolactone solution, both of which had a concentration of 0.03 mg / ml. Firstly, the polyurethane solution containing fluorescent carbocyanine dye was added to a syringe with a 23-gauge metering needle, pumped at a rate of 0.015 ml / min to 0.020 ml / min, and a voltage of 8 kV was applied to the needle tip to start electrospinning. use Figure 6The PU nanofiber layer was collected on the collection area shown, and then the PU nanofiber layer was stretched, and then the polycaprolactone solution containing green fluorescent dye was added to a syringe with a metering needle of 23, at 0...

Embodiment 2

[0086] By changing the ratio of elastic fiber and non-elastic fiber in the preparation process of fiber composite nonwoven mesh, the influence of different ratios on the mechanical properties of fiber composite nonwoven mesh was compared.

[0087] The elastic polymer molded by elastic nanofibers, the nonelastic polymer molded with nonelastic nanomaterials, and the preparation method of elastic nanofiber layer and nonelastic nanofiber layer are the same as in Example 1, that is, the elastic polymer used is the same as in Example 1. The PU described in 1, the non-elastic polymer is the PCL described in embodiment 1.

[0088] Such as Figure 12 As shown, the stress-strain curves of the fiber composite nonwoven mats with different ratios of elastic fibers and non-elastic fibers are different, so it can be known that the content ratio of elastic fibers and non-elastic fibers is the influence of the mechanical properties of fiber composite nonwoven mats one of the factors. in:

...

Embodiment 3

[0093] In the forming process of the fiber composite non-woven mat of the present invention, due to the different stretching degrees of the elastic nanofibers, the compression ratios of the non-elastic nanofibers are different. The influence of the compression rate of the non-elastic nanofiber layer on the mechanical properties of the fiber composite nonwoven mat was compared by making non-elastic nanofiber layers with different compression rates during the preparation process of the fiber composite nonwoven mat.

[0094] The elastic polymer formed by elastic nanofibers, the non-elastic polymer formed by non-elastic nanomaterials, and the preparation method of the elastic nanofiber layer and the non-elastic nanofiber layer are the same as in Example 1, that is, the elastic polymer used is the same as in Example 1. Described PU, nonelastic polymer are the PCL described in embodiment 1.

[0095] Set the original length and stretched length of PU nanofibers as L 0 and L 1 , the...

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Abstract

The invention discloses biocompatible fiber composite non-woven net felt and preparation method and application thereof. The biocompatible fiber composite non-woven net felt is made of composite materials comprising elastic nanofiber and non-elastic nanofiber, capable of highly simulating mechanical properties of original vascular tissues, and applied to artificial blood vessels for replacing transplantation or bypass transplantation. The fiber composite non-woven net felt preparation method that electrostatic spinning technology is adopted is simple in operation, the fiber composite non-woven net felt with needed mechanical properties can be prepared conveniently by changing ratios of the elastic fiber or the non-elastic fiber or adjusting drawing degrees of the elastic nanofiber in the preparation process of the fiber composite non-woven net felt, and therefore the mechanical properties of different original tissues can be simulated highly. By arrangement of diversified collection areas, preparation needs of the fiber composite non-woven net felt in different thicknesses, different mechanical properties and different shapes can be met.

Description

technical field [0001] The invention relates to a biocompatible fiber composite non-woven mat and its preparation method and application, in particular to a biocompatible fiber composite non-woven mat suitable for implantation in a living body and its preparation method, which can be It is used as an artificial blood vessel for replacement or bypass grafting. Background technique [0002] The environment in the living body has very strict requirements on implant materials. In addition to requiring that the implant materials do not trigger immune reactions in the body and have no physiological toxicity, they also need to maintain the mechanical properties that match the in vivo system for as long as possible. One of the most common implant materials is artificial blood vessels, which are used to treat cardiovascular diseases such as arteriosclerosis. Arteriosclerosis is a chronic inflammatory reaction in the arterial wall caused by hardening of the arteries and reduced blood...

Claims

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Application Information

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IPC IPC(8): D04H1/42D04H1/435D04H1/4374D04H1/4382D04H1/728A61F2/06
Inventor 文学军赵鹏李寅莹刘静
Owner 广州帷幄生物科技有限公司
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