Biocompatible fiber composite non-woven net felt and preparation method and application thereof

Abstract

The invention discloses biocompatible fiber composite non-woven net felt and preparation method and application thereof. The biocompatible fiber composite non-woven net felt is made of composite materials comprising elastic nanofiber and non-elastic nanofiber, capable of highly simulating mechanical properties of original vascular tissues, and applied to artificial blood vessels for replacing transplantation or bypass transplantation. The fiber composite non-woven net felt preparation method that electrostatic spinning technology is adopted is simple in operation, the fiber composite non-woven net felt with needed mechanical properties can be prepared conveniently by changing ratios of the elastic fiber or the non-elastic fiber or adjusting drawing degrees of the elastic nanofiber in the preparation process of the fiber composite non-woven net felt, and therefore the mechanical properties of different original tissues can be simulated highly. By arrangement of diversified collection areas, preparation needs of the fiber composite non-woven net felt in different thicknesses, different mechanical properties and different shapes can be met.

Description

technical field [0001] The invention relates to a biocompatible fiber composite non-woven mat and its preparation method and application, in particular to a biocompatible fiber composite non-woven mat suitable for implantation in a living body and its preparation method, which can be It is used as an artificial blood vessel for replacement or bypass grafting. Background technique [0002] The environment in the living body has very strict requirements on implant materials. In addition to requiring that the implant materials do not trigger immune reactions in the body and have no physiological toxicity, they also need to maintain the mechanical properties that match the in vivo system for as long as possible. One of the most common implant materials is artificial blood vessels, which are used to treat cardiovascular diseases such as arteriosclerosis. Arteriosclerosis is a chronic inflammatory reaction in the arterial wall caused by hardening of the arteries and reduced blood...

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Problems solved by technology

[0003] However, the above-mentioned solutions still have deficiencies: Although surgical repair of diseased blood vessels is more thorough, it is traumatic and risky; patients undergoing stent implantation have a certain probability of post-stent restenosis six months later, The probability of thick blood vessels is about 20%, and the probability of thin blood vessels can reach 33%. With the passage of time, the patency rate of the original blood vessels will be greatly reduced. The patency rate of blood vessels is only 50%; while the artificial blood vessels made of existing materials are used for replacement grafting or bypass grafting, the patency rate of vascular grafts is even lower than that of native blood vessels

Conversely, if Figure 1B As shown, the blood vessel contains a harder artificial vascular implant segment, and the harder artificial vascular implant segment expands less than the native blood vessel under blood flow pressure, which will also cause the blood flowing through the artificial vascular implant segment disorders, which can lead to problems such as regenerative strictures

In addition, the blood flow disorder caused by the mismatch of mechanical properties between the implanted blood vessel and the original blood vessel tissue affects the vascular patency rate after vascular grafting to a certain extent, reducing the vascular patency rate.

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