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Five-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof

A technology for liver fibrosis and botanical medicine, which is applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of backward preparation and other problems, and achieve the effect of increasing efficacy and good application prospect.

Active Publication Date: 2013-07-10
SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the preparation of Fuzheng Huayu Capsules is relatively backward at present. Taking 5 capsules at a time causes gastrointestinal reactions in some patients. Although the developed tablets can reduce stomach discomfort, there is still a need to further improve the clinical efficacy of liver fibrosis

Method used

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  • Five-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof
  • Five-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof
  • Five-ingredient botanical composition for treating hepatic fibrosis and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0035]Anti-hepatic fibrosis curative effect of effective components of Fuzheng Huayu Compound:

[0036] 1.1 Animals:

[0037] 59 Wistar male rats, SPF grade, weighing 150±10 g, were provided by Shanghai Experimental Animal Center, Chinese Academy of Sciences, license number: SCXK (Shanghai): 2007-0005. All rats were raised in the SPF laboratory of the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, with normal diet and free drinking water.

[0038] 1.2 Main reagents:

[0039] Dimethylnitrosamine (DMN), purchased from Tokyo Chemical Industry Co., Ltd., batch number: MAL05; citric acid, analytically pure, batch number: F20080916; anhydrous sodium acetate, analytically pure, batch number: F20080714; trisodium citrate (Tri-sodium citrate), analytically pure, batch number: F20070110; 4-Dimethylamino benzaldehyde (4-Dimethylamino benzaldehyde), batch number: F20090516; Chloramines-T (chloramines-T), analytically pure, batch number: T20061130; Non...

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Abstract

The invention relates to a five-ingredient botanical composition for treating hepatic fibrosis and a preparation method thereof. In every kilogram by weight, the composition contains the following ingredients: 180-350 mg of crude cordyceps polysaccharide, 0.06-0.82 ml of fat-soluble cordyceps ingredient, 2-68 mg of gynostemma pentaphyllum saponin, 3-12 mg of gynostemma pentaphyllum polysaccharide and 0.1-4 mg of amygdalin. The method comprises the following steps of: (1) extracting five ingredients, namely, the crude cordyceps polysaccharide, the fat-soluble cordyceps ingredient, the amygdalin, the gynostemma pentaphyllum saponin and the gynostemma pentaphyllum polysaccharide; and (2) preparing original ingredient liquid and various clinical preparations according to combination doses. The five-ingredient botanical composition has the same role as that of a composition of cordyceps mycelia, red sage root and gynostemma pentaphyllum and can obviously improve the treatment effect and reduce side effects, thereby having good clinical application prospects.

Description

technical field [0001] The invention belongs to a herbal medicine component composition for treating liver fibrosis and a preparation method thereof, in particular to a five-component herbal medicine composition for treating liver fibrosis and a preparation method thereof. Background technique [0002] my country is a high-incidence region of chronic hepatitis B and other liver diseases in the world, and chronic liver diseases have caused great harm to the health of our people for a long time. However, the treatment of liver fibrosis is still a major difficulty in the treatment of chronic liver diseases. Since the 1980s, Shanghai University of Traditional Chinese Medicine has successfully created the new anti-hepatic fibrosis national traditional Chinese medicine "Fuzheng Huayu Capsule" (Guoyao Zhunzi 20020073). Composition, the effect is promoting blood circulation and removing blood stasis, benefiting essence and tonifying deficiency. Years of studies have confirmed that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/424A61P1/16A61K31/7028A61K31/715
Inventor 徐列明冯怡胡坪李医明沈岚刘崇敏李光伟涂驭斌潘一峰
Owner SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECH DEV