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Method for preparing drug for treating pediatric esophageal achalasia

A technology for achalasia and medicine is applied in the field of preparation of medicines for treating achalasia in children, and can solve the problems of lack of achalasia in children, high compliance with pain in children, and high recurrence rate, so as to reduce the types and dosage of medicines , Increase the burden on the liver and kidney, the effect of convenient taking

Inactive Publication Date: 2013-07-10
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs are not suitable for use in pediatrics, so now more endoscopic balloon dilation is used, but dilation often requires multiple times to achieve relief, and the recurrence rate is high, and children with severe pain have poor compliance
Therefore, there is currently a lack of medical treatment drugs for children with achalasia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1, the weight ratio of raw materials: 10 parts of Muhe, 6 parts of kapok bark, 3 parts of Poria cocos, 6 parts of tangerine peel, 3 parts of Artemisia annua root, 6 parts of terrazzo vine, 6 parts of kudzu root, 6 parts of Aescin , 6 parts of loofah, 1 part of Jiulixiang, 3 parts of burnt malt, and 10 parts of burnt grain sprouts.

Embodiment 2

[0034] Example 2, the weight ratio of raw materials: 20 parts of Muhe, 10 parts of kapok bark, 6 parts of Poria cocos, 10 parts of tangerine peel, 6 parts of Artemisia annua root, 10 parts of terrazzo, 10 parts of kudzu root, 10 parts of Aescin , 10 parts of loofah, 2 parts of Jiulixiang, 6 parts of burnt malt, and 20 parts of burnt grain sprouts.

Embodiment 3

[0035] Example 3, the weight ratio of raw materials: 30 parts of Muhe, 12 parts of kapok bark, 10 parts of poria cocos, 12 parts of tangerine peel, 10 parts of Artemisia annua root, 12 parts of terrazzo vine, 12 parts of kudzu root, 12 parts of Aescin , 12 parts of loofah, 5 parts of Jiulixiang, 10 parts of burnt malt, and 25 parts of burnt grain sprouts.

[0036] The Chinese medicine of embodiment 1~3 can be prepared by the following method:

[0037] (1) Extract the volatile oil from Pueraria lobata root, kapok bark, and Artemisia argyi root powder by steam distillation, and collect and mix for later use;

[0038] (2) Grind burnt grain buds and burnt malt through a 150-mesh sieve to form fine powder for later use;

[0039] (3) Muhe, Poria cocos, tangerine peel, scorpion vine, loofah, Aesculus chinensis, Jiulixiang, mix well and add 10 times the amount of water, add water to decoct twice, each time for 1 hour, combine the decoction, and let it stand; then Add 3~4 times of 95...

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PUM

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Abstract

The invention discloses a method for preparing a drug for treating pediatric esophageal achalasia. The drug is applied to the treatment of pediatric esophageal achalasia. The drug is characterized by being prepared from the following raw pharmaceutical materials in proportioning ratio by weight: fingerleaf rodgersflower rhizome, bombax malabaricum peel, paris polyphylla Sm., luffa cylindrica (L.) Roem., murraya jasminorage, poriacocos (Schw.) Wolf, citrus reticulata Blanco, rtemisia japonica Thunb., trachelospermum jasminoides (Lindl.) Lem., radix puerariae, hordeum vulgare L. and setaria italica Beauv.. The method comprises the following steps of: (1) extracting volatile oil from coarse powder of radix puerariae, bombax malabaricum peel and rtemisia japonica Thunb. for later use; (2) crushing setaria italica (L.) Beauv. into fine powder for later use; (3) carrying out water extraction and alcohol precipitation on fingerleaf rodgersflower rhizome, poriacocos (Schw.) Wolf, citrus reticulata Blanco, trachelospermum jasminoides (Lindl.) Lem., luffa cylindrica (L.) Roem., paris polyphylla Sm., murraya jasminorage and hordeum vulgare L., and drying so as to obtain a preliminary material; and (4) spraying the volatile oil into the preliminary material, adding the fine powder of setaria italica (L.) Beauv., uniformly mixing, sieving by using a 60-mesh sieve, and encapsulating. Proved by clinical trials, the drug prepared by the method has the characteristics of good treatment effect and high safety in the treatment of pediatric esophageal achalasia, so that the method is worthy of clinical application and popularization.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a preparation method of a medicine for treating children with achalasia. Background technique [0002] Pediatric achalasia (esophageal achalasia) is an esophageal motility disorder, which refers to a disease in which there is no peristalsis in the esophageal body after swallowing and poor relaxation of the cardiac sphincter. It is characterized by impaired relaxation of the lower esophageal sphincter (LES) during swallowing, and lack of peristaltic contraction of the smooth muscle segment of the esophagus, resulting in functional esophageal obstruction. The cause of this disease is unknown. It may be related to toxins, nutritional deficiencies, genes and local inflammation. Clinical studies have found that mental concerns can aggravate children's symptoms. Consider whether cortical nerve dysfunction is caused by mental stimulation, leading to central and autonomic n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61K9/48A61P1/00
Inventor 牟丽萍
Owner QINGDAO CENT HOSPITAL
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