Preparation based on gold, silver, gold-silver mixture and glutathione/chitosan, and application of preparation

A technology of glutathione and chitosan, applied in the application of disease treatment, in the field of synthesis of preparations, can solve the problems of difficult detection of diseased tissue, early symptoms of cancer, etc., to achieve real-time dynamic tumor targeted therapy, results Intuitive, easy-to-use effects

Active Publication Date: 2013-07-24
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the early symptoms of cancer are not obvious, it is difficult to be detected in time, and the current conventional histopathological diagnosis method is difficult to detect the biochemical and molecular abnormalities in diseased tissues and cells in the early stage. Therefore, it is necessary to find a convenient, fast and accurate early diagnosis of cancer. The method is of great significance, so researching more advanced diagnostic methods and preparations to achieve accurate and timely early diagnosis and treatment of cancer has always been one of the directions of people's efforts

Method used

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  • Preparation based on gold, silver, gold-silver mixture and glutathione/chitosan, and application of preparation
  • Preparation based on gold, silver, gold-silver mixture and glutathione/chitosan, and application of preparation
  • Preparation based on gold, silver, gold-silver mixture and glutathione/chitosan, and application of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A mixed solution of 0.01-1.0 mmol / L silver reagent and glutathione / chitosan with a concentration of 0.1-100mmol / L is added drop by drop for complexation until the solution is just clear; among them, glutathione / chitosan The polysaccharide mixed solution is obtained by mixing glutathione and chitosan at a volume ratio of 1:1;

[0026] The silver reagent is silver nitrate.

Embodiment 2

[0028] A mixed solution of 0.01-1.0 mmol / L silver reagent and glutathione / chitosan with a concentration of 0.1-100mmol / L is added drop by drop for complexation until the solution is just clear; among them, glutathione / chitosan The polysaccharide mixed solution is obtained by mixing glutathione and chitosan at a volume ratio of 1:1;

[0029] The silver reagent is silver ammonia solution.

Embodiment 3

[0031] A mixed solution of gold reagent with a concentration of 0.05-5.0 mmol / L and glutathione / chitosan with a concentration of 0.1-100 mmol / L is added drop by drop for complexation until the solution is just clear; glutathione The mixed solution of glycin / chitosan is obtained by mixing glutathione and chitosan at a volume ratio of 1:1;

[0032] The gold reagent is chloroauric acid.

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Abstract

The invention discloses a preparation based on gold, silver, a gold-silver mixture and glutathione/chitosan, and an application of the preparation. According to the preparation and the application, the precious metal gold and silver nano medicinal preparation prepared by in-situ biosynthesis of targeted pathological cells/tissues has excellent biocompatibility, good permeability and high target performance, can achieve high-space-time resolution and accurate location of nidus parts such as tumors, and can facilitate apoptosis of tumor cells; the relevant precious metal preparation can target pathological loca such as the tumor cells/tissues in an organism, effectively facilitate the apoptosis of the tumor cells and ablation of the tumor tissues, and serve as the potential medicinal preparation for early treatment of the tumors clinically; and the relevant preparation and the application of the preparation are simple and easy, good in targeted treatment effect, low in toxicity, and visual in result, can conduct polymorphic, multi-mode, real-time, dynamic, and clinical monitoring and treatment, and have wide medical clinical application values and prospects.

Description

technical field [0001] The present invention relates to the synthesis of preparations of precious metal gold, silver ions and glutathione / chitosan and targeted treatment methods for diseases such as tumors, in particular to precious metal gold, silver and a mixture of gold and silver, glutathione and chitosan The synthesis method of the preparation and its application in the treatment of living tumors and other diseases. Background technique [0002] As we all know, early detection of cancerous sites and timely targeted therapy are one of the most effective treatments for cancer. However, because the early symptoms of cancer are not obvious, it is difficult to be detected in time, and the current conventional histopathological diagnosis method is difficult to detect the biochemical and molecular abnormalities in diseased tissues and cells in the early stage. Therefore, it is necessary to find a convenient, fast and accurate early diagnosis of cancer. The method is of great ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61K47/36A61P35/00A61K33/242
CPCA61K31/722B22F9/24A61K38/063A61K9/0019A61K47/36A61K33/38A61P35/00A61K33/242A61K2300/00A61K33/24
Inventor 王雪梅高生平叶静王建玲
Owner SOUTHEAST UNIV
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