Optimum design method for piezoelectric type sprayer for printing cells

Abstract

The invention discloses an optimum design method for a piezoelectric type sprayer for printing cells. The optimum design method is mainly utilized to solve the problems that a spraying hole is easily plugged and the survival rate of cells is low when a present piezoelectric type sprayer is used for printing the cells. The method comprises the following steps: solving a speed of an appointed node on the basis of a structural limited element model of a piezoelectric actuator; establishing a computational fluid dynamic model of the sprayer and solving according to an initial parameter and the obtained speed to obtain a condition for drop forming and the pressure of each part in the sprayer; solving a pressure wave period according to the obtained pressure, correspondingly adjusting a voltage pulse width and solving a corresponding result again; and by aiming at the demand of a user on the drop forming, establishing an optimized mathematical model and utilizing a value optimizing algorithm to solve to obtain a design parameter which meets the demand of the user and has the minimal passage maximum pressure and design the piezoelectric type sprayer. According to the optimum design method, the problems that the spraying hole is plugged and the survival rate of cells is low when the piezoelectric type sprayer is used for printing a high-viscosity cell solution are solved, and the electromechanical integrated design of the sprayer is realized.

Description

technical field [0001] The invention belongs to the technical field of mechanical structures, and relates to a printer nozzle, in particular to a method for optimizing the design of a piezoelectric nozzle for cell printing. The problem of pore clogging and can effectively improve the survival rate of cells. Background technique [0002] Cell printing technology is an organic combination of rapid prototyping technology and biomanufacturing technology, which can solve problems that are difficult to solve in traditional tissue engineering, and has broad development prospects in the basic and applied research of biomedicine. In traditional tissue engineering, the repair of damaged organs is mainly to attach cells to pre-designed biological scaffold materials after in vitro culture and expansion to form a "cell + scaffold" complex, and then implant them into the body. corresponding lesion site. The cell printing technology uses the principle of self-assembly of cells in develop...

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Problems solved by technology

[0007] The purpose of the present invention is to avoid the shortcomings of the above-mentioned prior art, and to provide a piezoelectric nozzle optimization design method based on the integration of structure and control, so as to solve the problem of spraying when high-viscosity liquid is sprayed, while considering the structure and driving control parameters of the nozzle. Eliminates the problem of pore clogging and minimizes the rate of cell damage by minimizing the maximum pressure on the inkjet channel during printing

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