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High-stability compound chlorhexidine iodohydrin solution and preparation method thereof

A compound chlorhexidine iodine, high-stable technology, which can be used in pharmaceutical formulations, active ingredients of iodine compounds, and medical preparations with non-active ingredients, etc., can solve the problems of iodine loss, easy generation of drug-resistant bacteria, and increased synthesis costs. , to achieve the effect of reducing iodine loss, ingenious design and fast onset

Active Publication Date: 2013-07-31
宇昂科技有限公司
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Problems solved by technology

Although ethanol is a commonly used disinfectant, it has a denaturing effect on the life substance protein of bacteria, and the effect is also rapid, but it is easy to produce drug-resistant bacteria
[0007] In addition, in the traditional preparation of chlorhexidine iodide alcohol solution, the simple use of iodine and chlorhexidine complexation results in the loss of most of the iodine and increases the synthesis cost.

Method used

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  • High-stability compound chlorhexidine iodohydrin solution and preparation method thereof
  • High-stability compound chlorhexidine iodohydrin solution and preparation method thereof
  • High-stability compound chlorhexidine iodohydrin solution and preparation method thereof

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preparation example Construction

[0034] 1.3 Preparation of highly stable compound chlorhexidine iodine alcohol solution

[0035] Add 0.1-2 parts by weight of 10% PVPI, 0.1-1 parts by weight of chlorhexidine acetate and 0.01-0.23 parts by weight of iodine into a three-necked flask containing 50-70 parts by weight of ethanol, and simultaneously add 0.01-0.3 parts by weight of KI , stirring and reacting for about 2-3 hours at 40-60° C. under sealed conditions, and then adding 0.1-2 parts by weight of surfactant and humectant and 29.36-42.69 parts by weight of water after cooling. Finally, adjust the pH to 2-4 with phosphoric acid.

[0036] 1.4 Determination of available iodine content

[0037] The available iodine concentration of the sample can be determined with reference to the potentiometric titration method in the Chinese Pharmacopoeia [2] method. In this experiment, the potentiometric titration method in the Chinese Pharmacopoeia was used to measure the effective iodine content: accurately pipette 25ml o...

Embodiment 1

[0080] Add 0.1 parts by weight of 10% PVPI, 0.1 parts by weight of chlorhexidine acetate and 0.23 parts by weight of iodine into a three-necked flask filled with 70 parts by weight of ethanol, and add 0.01 parts by weight of KI at the same time, and stir the reaction at 40°C under sealed conditions for 3 About hour, just add the tensio-active agent (0.01 weight part K30 of 0.09 weight part OB-2 and the humectant glycerin of 0.1 weight part after cooling, and the water of 29.36 weight parts respectively after cooling. Regulate pH with phosphoric acid at last to be 2 .

[0081] After testing, the sample was prepared according to the disinfection technical specifications and the requirements of the Chinese Pharmacopoeia. The available iodine was 0.19%. After the stability test was accelerated for 14 days, the degradation rate was 6.11%. It was applied on the arm, and the arm was dry after 2-3 minutes. No obvious yellowing phenomenon, easy to wash off with water. The average kill...

Embodiment 2

[0086] Add 1 part by weight of 10% PVPI, 0.51 parts by weight of chlorhexidine acetate and 0.13 parts by weight of iodine into a three-necked flask filled with 60 parts by weight of ethanol, and add 0.15 parts by weight of KI at the same time, and stir the reaction at 50 °C under sealed conditions for 2.5 About hours, after cooling, 1 part by weight of surfactant NP-10, 1 part by weight of humectant K30, and 36.21 parts by weight of water were added respectively. Finally, the pH was adjusted to 3 with phosphoric acid.

[0087] After testing, the sample was prepared according to the disinfection technical specifications and the requirements of the Chinese Pharmacopoeia. The available iodine was 0.2%. After the stability test was accelerated for 14 days, the degradation rate was 3.11%. It was applied on the arm, and the arm was dry after 2-3 minutes. No obvious yellowing phenomenon, easy to wash off with water. In the microbial sterilization test, the average kill log value of ...

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Abstract

The invention relates to a high-stability compound chlorhexidine iodohydrin solution. The high-stability compound chlorhexidine iodohydrin solution comprises the following components in parts by weight: 0.2-1 part of 10% of PVPI (Polyvinylpyrrolidone Iodine), 0.1-1 part of chlorhexidine acetate, 0.01-0.23 part of iodine, 50-70 parts of ethanol, 0.01-0.3 part of KI (Potassium Iodide), 0.1-2 parts of surfactant, 0.1-2 parts of humectants and 29.36-42.69 parts of water, wherein the pH value of the solution is regulated to 2-4 by phosphoric acid. The invention further relates to a preparation method of the high-stability compound chlorhexidine iodohydrin solution. The high-stability compound chlorhexidine iodohydrin solution disclosed by the invention is delicate in design, broad-spectrum in sterilizing effect, quick to become effective, capable of preventing drug-resistance bacteria from generating, quick to dry, more stable and longer in continuous sterilizing time, so that not only can effective content of sterilizing agent iodine in the product be satisfied, but also the iodine loss is reduced and the cost is lowered. Meanwhile, the high-stability compound chlorhexidine iodohydrin solution is capable of enabling the product to be more stable without stained yellow and capable of forming a protective film at the periphery of the wound without causing local infection, easy to clean and suitable for large-scale popularization and application.

Description

technical field [0001] The invention relates to the technical field of disinfectants, in particular to the technical field of chlorhexidine iodide solution, in particular to a highly stable compound chlorhexidine iodide solution and a preparation method thereof. Background technique [0002] At present, the main disinfectants at home and abroad mainly fall into the following three categories: [0003] Disinfectants with iodine as the main component, such products on the market mainly include povidone iodine, iodophor, iodine tincture and so on. There are many povidone-iodine products on the market, but these products are mainly disinfected with the original solution, and the concentration of available iodine is relatively high, and it is not easy to dry, while iodine tincture is easy to yellow and is not very popular with consumers. Iodophor requires higher concentration and poor stability. [0004] Chlorhexidine disinfectant is widely used in surgical disinfection by the ...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K47/34A61K9/08A61P31/02A61K31/155A61K47/10A61K47/32
Inventor 王宇胡俊涛陈占
Owner 宇昂科技有限公司
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