Pradaxa analogue with fluorine-containing group modified benzene ring as center and synthesis method thereof
A dabigatran etexilate and synthetic method technology, applied in organic chemistry, acaricides, etc., can solve the problems of high toxicity, increased risk in the preparation process, increased preparation cost of dabigatran etexilate analogues, etc., to achieve Effects of increased fat solubility and decreased drug metabolism rate
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0056] A kind of dabigatran etexilate analog centered on the phenyl ring modified by fluorine-containing group, with R in Fig. 3 1 for -F; R 2 for-C 2 h 5 For example, 3-[[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-ethyl-1H-benzene Ethyl imidazol-5-yl]carbonyl](4-fluorophenyl)amino]propionate.
[0057] The above-mentioned dabigatran etexilate analogue centered on a fluorine-containing group-modified benzene ring, that is, 3-[[[2-[[[4-[[[(hexyloxy)carbonyl]amino]imino Methyl] phenyl] amino] methyl] -1-ethyl-1H-benzimidazol-5-yl] carbonyl] (4-fluorophenyl) amino] the synthetic method of ethyl propionate, promptly with 4- Fluoroaniline is used as a raw material, and 3-[[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1 is synthesized through 9 steps of reaction -ethyl-1H-benzimidazol-5-yl] carbonyl] (4-fluorophenyl) amino] ethyl propionate, each step of synthetic reaction is as follows:
[0058] (1) Synthesis of compound 1, n...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com