Multi-channel micro-fluidic chip and mass spectrum combined device

Abstract

The invention discloses a multi-channel micro-fluidic chip and mass spectrum combined device. The multi-channel micro-fluidic chip and mass spectrum combined device comprises a micro-fluidic chip and an electric spraying mass spectrometer. The micro-fluidic chip is provided with a plurality of micro channels which are connected in parallel, and the outlet of each micro channel is communicated with a chamber. Each chamber is communicated with a main channel, and the other end of each main channel is a waste liquid outlet. One end of each main channel is close to a chamber and is communicated with a side channel, and the free end of the side channel is an extraction agent inlet. Height difference exists between the side channel and the main channel, and the upper rim of the side channel is arranged on the lower portion of the upper rim of the main channel. Sample outlets are communicated with sample outlet pipes respectively, wherein the outlets of the sample outlet pipes are arranged above the electric spraying device, and liquid drops generated by the electric spraying device is detected by the electric spraying mass spectrometer. A plurality groups of experiments can be simultaneously conducted by the multi-channel micro-fluidic chip and mass spectrum combined device, and real-time mass spectrum detection can be conducted after on-line sample pretreatment is conducted in the micro-fluidic chip.

Description

technical field [0001] The invention relates to a multi-channel microfluidic chip-mass spectrometer coupling device. Background technique [0002] Microfluidic chip technology has received more and more attention due to its low consumption, high throughput, and high integration. Through different designs, microfluidic chips can achieve a variety of functions, such as fluid manipulation, sample processing, biochemical reactions, etc. These functions make microfluidic chips have a very wide range of application prospects, especially in biology and medicine. field applications are of great importance. The size of the microfluidic chip structure can be close to biological tissue, and different structures can be integrated hierarchically and methodically, which makes the microfluidic chip have great advantages in simulating biological tissues or organs, as documented in Goral V.N. ; Hsieh Y.-C.; Petzold O.N.; Clark J.S.; Yuen P.K.; Faris R.A. Reversed membrane polarity and pro...

AI Technical Summary

Problems solved by technology

However, at this stage, the combination of mass spectrometry detection technology and microfluidic chip technology is far from meeting the needs of microfluidic chip technology.

At this stage, most of the connection between mass spectrometry and microfluidic chip technology is only for one microfluidic chip channel. For microfluidic chip systems with multi-channel parallel experiments or multiple experiments, there is no simple and efficient way to combine mass spectrometry with it, thus The application of mass spectrometry in high-throughput microfluidic chip systems is limited

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