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Entero-soluble type compound acidifier pellet and preparation method thereof

A compound acidifier and enteric-coated technology, which is applied in the direction of active ingredients of anhydride/acid/halide, digestive system, drug combination, etc., can solve the problems of ineffective acidifier, affecting gastric acid secretion of piglets, and excessive release speed, etc. , to achieve the effect of easy popularization and use, low production cost and reasonable formula

Inactive Publication Date: 2013-08-07
四川省川龙动科药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide an enteric-coated compound acidifier pellet and its preparation method, which solves the problem that the effect of the existing acidifier is not obvious, and the release speed in the stomach is too fast to stimulate the gastric mucosa and affect the gastric acid of the piglet itself. secretion problem

Method used

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  • Entero-soluble type compound acidifier pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of enteric-coated compound acidifier pellet, by weight, by the fumaric acid of 15%, the citric acid of 10%, the malic acid of 7.5%, the lactic acid of 12.5%, the corncob powder of 20%, 10% of Microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% enteric coating layer. Among them, the enteric coating layer is composed of 40% Eudragit L100 aqueous dispersion, 1% triethyl citrate, 2% talcum powder and 57% purified water.

[0030] The specific preparation method is as follows:

[0031] (1) Weigh the pulverized fumaric acid, citric acid, malic acid, corncob powder, microcrystalline cellulose, and sodium carboxymethyl starch according to the above ratio, mix well, then add lactic acid and mix well;

[0032] (2) Prepare a 3.0% aqueous solution of hydroxypropyl methylcellulose and add it to the mixture as a binder to obtain a soft material. The added hydroxypropylmethylcellulose accounts for 50% of the weight of the mixture in step (1). 15%;

[0033] (3)...

Embodiment 2

[0038] Compared with Example 1, this example differs only in that the proportioning of a kind of enteric-coated compound acidifier pellet is different, and the proportioning of this example is as follows:

[0039] A kind of enteric-coated compound acidifier pellet, by weight, by the fumaric acid of 15%, the citric acid of 10%, the malic acid of 7.5%, the lactic acid of 12.5%, the corncob powder of 10%, 15% of Microcrystalline cellulose, 15% sodium carboxymethyl starch and 15% enteric coating layer. Among them, the enteric coating layer is composed of 40% Eudragit L100 aqueous dispersion, 1% triethyl citrate, 2% talcum powder and 57% purified water.

Embodiment 3

[0041] Compared with Example 1, this example differs only in that the proportioning of a kind of enteric-coated compound acidifier pellet is different, and the proportioning of this example is as follows:

[0042] A kind of enteric-coated compound acidifier pellet, by weight, by the fumaric acid of 13%, the citric acid of 12%, the malic acid of 9.5%, the lactic acid of 10.5%, the corncob powder of 10%, 15% of Microcrystalline cellulose, 15% sodium carboxymethyl starch and 15% enteric coating layer. Among them, the enteric coating layer is composed of 40% Eudragit L100 aqueous dispersion, 1% triethyl citrate, 2% talcum powder and 57% purified water.

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Abstract

The invention discloses an entero-soluble type compound acidifier pellet and a preparation method thereof, which can be used for solving the problems that the existing acidifier is unobvious in effect, capable of causing stimulation to gastric mucosa due to high release speed in the stomach, capable of affecting gastric acid secretion of piglets. The entero-soluble type compound acidifier pellet comprises the following components in percentage by weight: 75%-90% of pellet core and 10%-25% of enteric coating layer, wherein the pellet core includes 40%-60% of compound organic acid and 40%-60% of auxiliary materials. The invention further provides a preparation method of the entero-soluble type compound acidifier pellet. The pellet disclosed by the invention is enabled to be insoluble in the stomach, soluble in small intestines and large intestines, so that medicine liquor is released in a located manner, and therefore, the effect of adjusting acid-base equilibrium of intestinal tracts of weaned pigs and gastrointestinal tract growth and development can be improved. Moreover, the entero-soluble type compound acidifier pellet is easily available in material, reasonable in composition, low in production cost, simple in process flow and easy to popularize and use.

Description

technical field [0001] The invention relates to an enteric-coated composite acidifier pellet and a preparation method thereof. Background technique [0002] At present, there are many acidulant products on the market that are used to regulate the intestinal acid-base balance of weaned piglets and the growth and development of the gastrointestinal tract, prevent diarrhea and promote growth of weaned piglets. It has a certain effect of promoting growth and preventing diarrhea of ​​weaned piglets. Studies have found that the high intestinal pH of weaned piglets will not only affect the activity of digestive enzymes in the small intestine, but also cause the proliferation of pathogenic bacteria, resulting in nutritional or pathogenic diarrhea in piglets. After long-term clinical application and experimental research, it is found that common acidifiers without protection can easily release H in the stomach quickly. + , but cannot reach the small intestine and large intestine, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K9/16A61P3/12A61P1/12A61K31/19
Inventor 靳茹文林芝李英伦严根文胡衍瑞
Owner 四川省川龙动科药业有限公司
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