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Preparation method of high-orientation nanometer hydroxyapatite crystalline colloidal array

A technology of nano-hydroxyapatite and crystal array, applied in the field of nano-manufacturing

Active Publication Date: 2013-08-14
星途(常州)碳材料有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

No domestic and foreign patent applications and authorizations have been seen for the preparation method related to the present invention

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  • Preparation method of high-orientation nanometer hydroxyapatite crystalline colloidal array

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Embodiment 1

[0020] Take an ordinary glass slide, immerse it in 4mol / L sodium hydroxide solution at 60°C, take it out after 8 hours, wash it with deionized water, and dry it at room temperature. Submerge the hot-alkali-treated sample in 10ml of calcium chloride aqueous solution with a concentration of 1.0mol / L, react at 60°C for 8h, take the sample out and place it in an oven at 80°C for drying. Then immerse the sample in 10ml of disodium hydrogen phosphate solution with a concentration of 0.02mol / L and a pH of 10, keep it warm at 90°C for 12h, take out the sample and wash it with deionized water, then dry it with warm air, and observe the surface structure with SEM. It can be seen that a large area of ​​nano-hydroxyapatite crystals with a hexagonal structure has been generated on the surface of the glass slide, and the size of the hydroxyapatite crystals is uniform, with a diameter of 80.3 ± 3.7nm ( figure 1 ), it can be seen from the cross-sectional SEM that the length of nano-hydroxyapa...

Embodiment 2

[0022] The size is 2×20×80mm 3 Immerse the quartz glass in 8mol / L potassium hydroxide solution at 60°C, take it out after 10h, wash it with deionized water three times, and dry it in an oven at 60°C. Then immerse the hot-alkali-treated sample in 10ml of calcium chloride aqueous solution with a concentration of 2.0mol / L, react at 60°C for 8h, take the sample out and place it directly in an oven at 80°C for drying. Then immerse the sample in 10ml of disodium hydrogen phosphate solution with a concentration of 0.03mol / L and a pH of 11, soak for 24h at 37°C, take out the sample and wash it with deionized water, then dry it at room temperature, and observe the surface structure with SEM , it can be seen that nano-hydroxyapatite crystals with a large area of ​​hexagonal sheet structure are formed on the surface of the sample, and the size of the hydroxyapatite crystals is uniform, and the thickness is 38.0±8.9nm ( Figure 4 ), the EDS spectrum shows that the crystals are mainly com...

Embodiment 3

[0024] The size is 2×20×80mm 3 The conductive glass was immersed in a 6mol / L sodium hydroxide solution at 80°C, taken out after 5 hours, cleaned with deionized water, and dried in an oven at 60°C. Then the sample was immersed in 10ml of calcium nitrate aqueous solution with a concentration of 2.0mol / L, reacted at 80°C for 4h, and the sample was taken out and directly dried in an oven at 60°C. Then immerse the sample in 10ml of potassium dihydrogen phosphate solution with a concentration of 0.05mol / L and a pH of 10, soak for 24 hours at 85°C, take out the sample and wash it with deionized water, then dry it with warm air, and observe the surface structure with SEM , it can be seen that nano-hydroxyapatite crystals with a large area of ​​needle-like structure are formed on the surface of the sample. The size of the hydroxyapatite crystals is uniform, with a diameter of 45.2±3.2nm and a length of 548.2±23.5nm. The EDS spectrum shows that the crystals are mainly composed of calciu...

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Abstract

The invention relates to a preparation method of a high-orientation nanometer hydroxyapatite crystalline colloidal array. The method comprises the following steps of: (1) dipping a cleaned substrate material into a hot alkali solution, taking the substrate material out when the substrate material is treated by the hot alkali solution for certain time, cleaning the substrate material using deionized water, and drying the cleaned substrate material; (2) dipping the dried substrate material into a calcium salt solution, taking the substrate material out after reaction for certain time, and directly drying the substrate material without cleaning; and 3) vertically dipping the again dried substrate material into a phosphate solution, keeping the substrate material in the phosphate solution at certain pH (Potential of Hydrogen) and temperature for certain time, then taking the substrate material out, cleaning the substrate material using deionized water, and drying the cleaned substrate material to obtain the high-orientation nanometer hydroxyapatite crystalline colloidal array. The method provided by the invention achieves the formation and structure control of the nanometer hydroxyapatite crystalline colloidal array by changing chemical conditions, is stable in process, low in cost and capable of achieving large-scale production, and has wide application values to the fields of material surface modification, biological information detection, disease diagnosis and the like.

Description

technical field [0001] The invention relates to a preparation method of a highly oriented nano-hydroxyapatite crystal array, belongs to the field of nano-manufacturing, and can be used in aspects such as material surface modification, biological information detection, and disease diagnosis. Background technique [0002] Like other natural materials, the basic composition, shape, size and spatial position of natural bone tissue determine the anisotropy of the intrinsic structure and properties of bone. Natural bone is a composite material composed of an orderly combination of an inorganic phase dominated by nano-hydroxyapatite (nHA) and an organic phase dominated by collagen. In bone, the c-axis direction of nano-hydroxyapatite is preferentially arranged along the extension direction of collagen fibers, and this ordered structure ensures maximum mechanical properties. The fundamental reason why normal bone has higher compressive strength than decalcified bone is that the ani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 黄棣魏延郭美卿王鹤峰武晓刚连小洁王晓君韩志军
Owner 星途(常州)碳材料有限责任公司
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