Thin-layer chromatoplate having ordered micro-nano structure and manufacturing method thereof

A thin-layer chromatographic plate and a technology of micro-nano structure are applied in the field of thin-layer chromatographic plate and its preparation to achieve the effect of extending the application range, lowering the detection limit and improving the flow rate

Inactive Publication Date: 2013-08-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, there have been no reports in the literature on inverse opal-structured films with periodic arrangements and mesoporous modifications for thin-layer chromatography

Method used

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  • Thin-layer chromatoplate having ordered micro-nano structure and manufacturing method thereof

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Embodiment 1

[0033] Monodisperse solid polystyrene microspheres with a particle size ranging from tens of nanometers to several microns were prepared by the improved St?ber method. Take 1ml, 2.5vol% PS colloidal solution with a particle size of 240nm and add it to 20ml ultrapure water, then add 0.3ml TEOS prepolymer solution to it, stir at room temperature for 1h and set aside. Insert the glass slide treated with piranha solution vertically into the prepared precursor solution, let it stand at 65°C for 2 days, and then dry it in a constant temperature oven. The drying temperature is controlled at 105-110°C, and the drying time is about 2-3 hours. After drying, it was placed in a muffle furnace for calcination at 500 °C for 4 h and then cooled to room temperature. Observation by SEM shows that the obtained TLC film has an inverse opal structure. Finally, the prepared inverse opal structure was immersed in a silica gel solution prehydrolyzed with a block copolymer surfactant for 24 h, so th...

Embodiment 2

[0038] Monodisperse solid silica microspheres with a particle size ranging from tens of nanometers to several micrometers were prepared by the improved Stäber method. The growth of the monodisperse mesoporous silica shell was achieved by adding a surfactant to control the seed growth, and finally the mesoporous silica microspheres with good monodispersity were obtained. Subsequently, a mesoporous silica colloidal solution with a particle size of 1 um and a concentration of 45% was selected, and a photonic crystal film with a highly ordered micro-nano structure was prepared by a vertical deposition method. Put the film at 65°C for 2 days and then dry it in a constant temperature oven. The drying temperature is controlled at 105-110°C, and the drying time is about 2-3 hours. After drying, add the pre-prepared polystyrene solution dropwise on the surface of the film Let it stand for a period of time, so that the polystyrene solution completely fills the gaps between the silica mi...

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Abstract

The invention discloses a thin-layer chromatoplate having an ordered micro-nano structure and a manufacturing method thereof. The thin-layer chromatoplate comprises a base plate and a stationary phase on the base plate. The stationary phase comprises a skeleton having an ordered micro-nano inverse opal structure, and a mesoporous microstructure. The skeleton having the ordered micro-nano inverse opal structure is prepared by a photonic crystal film as a template. The surface of the skeleton having the ordered micro-nano inverse opal structure is modified by the mesoporous microstructure. The thin-layer chromatoplate utilizes the photonic crystal having the inverse opal structure as the skeleton. The inverse opal structure can provide enough micro- and nano-mesopores so that a flowing rate can be greatly improved; and a thin-layer chromatographic resolution ratio is obviously improved and good reappearance is obtained. Through combination of the thin-layer chromatogram and photonic crystals, an application scope is greatly expanded.

Description

technical field [0001] The invention relates to a thin-layer chromatographic plate with an ordered micro-nano structure and a preparation method thereof. It can be used for qualitative and semi-qualitative analysis of mixtures of natural compounds, drugs, chemicals and microbial synthesis, and is widely used in rapid quality detection, rare metal separation, clinical drug detection, pesticide residue analysis and other fields. Background technique [0002] With the improvement of industry standards and the gradual increase of practical applications, chromatography has become a unique banner of analytical applications in the 21st century, and the most important achievement is the discovery of thin-layer chromatography (TLC). As a kind of parallel chromatography, TLC occupies a place in various scientific research laboratories, factories, schools and other places due to its advantages of simple operation and low cost. [0003] A typical TLC chromatographic process is mainly a...

Claims

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Application Information

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IPC IPC(8): G01N30/92
Inventor 赵祥伟刘扬顾忠泽
Owner SOUTHEAST UNIV
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