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Acidic cleaner for full-automatic biochemical analyzer and preparation method thereof

A technology of biochemical analyzer and acid cleaning agent, which is applied in the field of cleaning agent, can solve the problems of carrying pollution, large damage load of flow system, unsatisfactory application effect of cleaning agent, etc., and achieves small environmental load, meets environmental protection requirements, and good cleaning effect of effect

Inactive Publication Date: 2013-09-04
SUZHOU KANGHESHUN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The actual application effect of cleaning agents produced and supplied in China is not ideal. Many manufacturers pursue the cleaning effect one-sidedly, and even add too many surfactant components or strong acid / alkali to improve the cleaning effect, so that the cleaning agent will damage the flow system of the instrument. The load is very large, and there is a case of carrying pollution brought by the cleaning agent, so many products still cannot meet the needs of users

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: first take 700mL of pure water with a graduated cylinder, then slowly add 45mg of tartaric acid into it to dissolve and stir evenly, then transfer it into a 1L volumetric flask. Then slowly add 40mL of polyoxyalkylene alkyl ether and 2mL of alkyltrimethylammonium chloride salt to make the volume 1L, and stir evenly to obtain 1L of stable cleaning agent for automatic biochemical analyzer.

[0026] Use Hitachi 7600 automatic biochemical analyzer to test the cleaning performance of the above-mentioned acid cleaning agent. The test indicators include the residual rate of protein substances, the residual rate of lipid substances, the deposition of reactants, the intra-batch repeatability of clinical projects, cross-contamination, especially glycerin Cross-contamination of triester reactants, correlation of measurement results when using original acidic cleaning agents, etc.

[0027] In the test results, all performance test indicators are within the controllable t...

Embodiment 2

[0028] Example 2: First, take 700mL of pure water with a measuring cylinder, then slowly add 63mg of citric acid into it to dissolve and stir evenly, then transfer it into a 1L volumetric flask. Then slowly add 40mL of polyoxyalkylene alkyl ether and 2mL of alkyltrimethylammonium chloride salt to make the volume 1L, and stir evenly to obtain 1L of stable cleaning agent for automatic biochemical analyzer.

[0029] Use Hitachi 7600 automatic biochemical analyzer to test the cleaning performance of the above-mentioned acid cleaning agent. The test indicators include the residual rate of protein substances, the residual rate of lipid substances, the deposition of reactants, the intra-batch repeatability of clinical projects, cross-contamination, especially glycerin Cross-contamination of triester reactants, correlation of measurement results when using original acidic cleaning agents, etc.

[0030] In the test results, all performance test indicators are within the controllable ta...

Embodiment 3

[0031] Example 3: first take 700mL of pure water with a graduated cylinder, then slowly add 45mg of tartaric acid to it to dissolve and stir evenly, then transfer it into a 1L volumetric flask. Then slowly add 80mL of polyoxyalkylene alkyl ether and 40mL of alkyltrimethylammonium chloride salt to a volume of 1L, and stir evenly to obtain 1L of stable cleaning agent for automatic biochemical analyzer.

[0032] Test the cleaning performance of the above-mentioned acid cleaning agent with Hitachi 7600 automatic biochemical analyzer. The test indicators include the residual rate of protein substances, the residual rate of lipid substances, the deposition of reactants, the intra-batch repeatability of clinical projects, cross-contamination, especially glycerin Cross-contamination of triester reactants, correlation of measurement results when using original acidic cleaning agents, etc.

[0033]In the test results, all performance test indicators are within the controllable target ra...

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PUM

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Abstract

The invention relates to an acidic cleaner for a full-automatic biochemical analyzer and a preparation method thereof. The cleanser comprises 0.3 mmol / L at least one organic acid, 4-8 wt% of at least one nonionic surfactant, 0.1-2.0 wt% of at least one cationic surfactant and the balance of water. The organic acid can be tartaric acid or citric acid; the nonionic surfactant can be polyoxyalkylene alkyl ether, wherein the carbon atom number of alkyl group is 12-15; and the cationic surfactant can be alkyldimethylammonium chloride. The cleanser provided by the invention has the characteristics of favorable in-batch repetitiveness of clinical detection projects, low cross contamination and low reactant deposition, does not have any corrosive action on the reaction cup and flow path system of the analyzer in the cleaning process, does not have potential pollution on the environment, and satisfies the requirement for environmental protection.

Description

technical field [0001] The invention relates to a cleaning agent, in particular to an acidic cleaning agent used for a fully automatic biochemical analyzer when analyzing samples (including serum, plasma, urine, cerebrospinal fluid, etc.) and a preparation method thereof. Background technique [0002] The automatic biochemical analyzer is an instrument for measuring a specific chemical composition in body fluids (including serum, plasma, urine, cerebrospinal fluid, etc.) based on the principle of photoelectric colorimetry. and health status. Due to its fast measurement speed, high accuracy, and small consumption of reagents, the number of fully automatic biochemical analyzers in the world, especially in China, is increasing year by year. Now it is used in hospitals at all levels in my country, epidemic prevention Websites and family planning service stations are widely used. The test accuracy of the automatic biochemical analyzer directly affects the doctor's diagnosis result...

Claims

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Application Information

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IPC IPC(8): C11D1/835C11D3/20
Inventor 李晴
Owner SUZHOU KANGHESHUN MEDICAL TECH