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Xiaomi vagina expansion suppository, preparation method and detection method thereof

A technology of vaginal expansion suppository and detection method, which is applied in the directions of suppository delivery, pharmaceutical formulations, material inspection products, etc., can solve the problems of easily contaminated clothing, insufficient absorption, small contact surface, etc., to avoid secondary infection and achieve faster drug release Fast and prevent outflow effect

Active Publication Date: 2013-09-11
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing Xiaomi suppository generally has the following problems: 1. It is not easy to clean, and it is easy to contaminate clothes; 2. The contact surface between the active drug and the human body is small, resulting in insufficient absorption, and the best curative effect of the prescription is not exerted; 3. The dissolution rate of the drug Poor; 4. The active ingredient and the matrix are unevenly mixed, and it is not easy to bond; 5. The drug takes effect quickly and the effective administration time is short; 6. There are peaks and valleys after medication, and the blood concentration is unstable, etc.

Method used

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  • Xiaomi vagina expansion suppository, preparation method and detection method thereof
  • Xiaomi vagina expansion suppository, preparation method and detection method thereof
  • Xiaomi vagina expansion suppository, preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101]

[0102] Preparation:

[0103] 1) Preparation of drug-containing matrix:

[0104] a. Polyoxyethylene monostearate and glycerin are placed in a water bath for heating and melting to obtain a melt;

[0105] b. Preparation of active ingredients:

[0106] 1 Weigh the sophora flavescens of prescription quantity, pulverize, cross 20 mesh sieves, soak 2h with 70% ethanol solution, then reflux extract with 75% ethanol solution for 2h, combine extracts, filter, condense into thick paste, thicken paste Porous resin, eluted with ethanol solution, collected ethanol eluate, concentrated, dried, and crushed into fine powder;

[0107] II Weigh the Phellodendron Phellodendron and Comfrey in the prescribed amount, crush them, pass through a 20-mesh sieve, add water and decoct three times, the first decoction for 2 hours, the second and third decoctions for 1 hour each, combine the decoctions, filter, and concentrate until the temperature is 80 Add 70% ethanol to the clear ointment...

Embodiment 2

[0114]

[0115] Preparation:

[0116] 1) Preparation of drug-containing matrix:

[0117] a. Polyoxyethylene monostearate and glycerin are placed in a water bath for heating and melting to obtain a melt;

[0118] b. Preparation of active ingredients:

[0119] 1 Weigh the sophora flavescens of prescription quantity, pulverize, cross 40 mesh sieves, soak 5h with 60% ethanol solution, then reflux extract with 75% ethanol solution for 1h, combine extracts, filter, condense into thick paste, thicken paste Porous resin, eluted with ethanol solution, collected ethanol eluate, concentrated, dried, and crushed into fine powder;

[0120] II Weigh Phellodendron Phellodendron and Comfrey in the prescribed amount, pulverize, pass through a 40-mesh sieve, add water and decoct three times, the first decoction for 2 hours, the second and third decoction for 1 hour each, combine the decoction, filter, and concentrate until the temperature is 80 Add 85% ethanol to the clear paste with a re...

Embodiment 3

[0128]

[0129] Preparation:

[0130] 1) Preparation of the hollow shell: heat and melt polyoxyethylene monostearate and glycerin in a water bath to obtain a melt, inject the melt into the plug mold, place it, turn over the plug mold, and let the uncondensed matrix flow out. form a cavity;

[0131] 2) Insert 1 / 5-4 / 5 of the front end of the expansion carrier into the cavity of the hollow casing to form a cavity containing the expansion carrier;

[0132] 3) Preparation of active ingredients:

[0133] a. Preparation of active ingredient: prepare active ingredient according to step b of Example 1;

[0134] 4) Put the active ingredient into the cavity containing the expansion carrier described in step 2), and seal the tail with the melt described in step 1);

[0135] 5) cooling and setting, making 1000 spherical suppositories, each weighing about 2.7g.

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Abstract

The present invention relates to a Xiaomi vagina expansion suppository, which comprises an active component, a matrix and an expansible expansion carrier. The present invention further relates to a preparation method and a detection method of the expansion suppository. According to the expansion suppository, seven original leading technologies are adopted; the expansion suppository is made into a hollow expansion suppository, and the matrix and the active component are completely separated, such that stability of the expansion suppository is increased compared with stability of the ordinary suppository; the active component, the dispersion carrier and the absorption blocking agent are combined so as to increase an active component dissolution rate, well release the active component, and prolong a drug action time; and the Xiaomi vagina expansion suppository has effects of rapid effect, prolonged action time, drug liquid outflow prevention, vagina cleaning, secondary infection prevention, and the like.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Xiaomi vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] Xiaomi suppository is included in the twentieth volume of "Ministry of Health Drug Standards for Traditional Chinese Medicine Prescriptions" and also included in the Chinese Pharmacopoeia. A vaginal suppository made from catechu seven-flavored medicine with polyoxyethylene monostearate and glycerin in a certain weight ratio; For cervical erosion, trichomonal vaginitis, fungal vaginitis, non-specific vaginitis and mycoplasma infection, gonorrhea infection and other diseases. [0003] The prior art also has other dosage forms made of the above-mentioned 7 herbs and additives; as CN1672704 discloses the vaginal effervescent tablets made of 7 ingredients such as ginsenoside and comfrey; Soft capsule suppository, ointment or film preparation made of seven...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/02A61P15/02A61P15/00A61P33/02A61P31/02G01N33/15G01N5/04A61K31/045A61K33/06
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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