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Compound intravenous anesthetic

An anesthetic and intravenous technology, applied in the field of medicine, can solve the problems of anesthesia risk, increased adverse reactions, and limited clinical application range, and achieve the effect of eliminating adverse reactions, low incidence of adverse reactions, and mild degree

Inactive Publication Date: 2013-10-23
陈希璇
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Increased risk of anesthesia and adverse reactions, limiting the scope of clinical application

Method used

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Experimental program
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Embodiment Construction

[0017] 1.1 Case selection: 600 cases of early pregnancy patients in the obstetric outpatient department, aged 20-35 years old, weight 40-75kg; ASA score I, no history of major organ diseases, no history of drug allergy. Routine preoperative examination: blood analysis, coagulation function, EKG, no food and drink before surgery for 8 hours. The cases were randomly divided into different ratio comparison groups of propofene (200mg / 20ml)-etomidate (20mg / 10ml) fat emulsion mixture. 200 cases per group.

[0018] Group A, dose ratio (mass ratio) 2.5:1; Group B, dose ratio (mass ratio) 4:1; Group C, dose ratio (mass ratio) 5.5:1.

[0019] 1.2 Drug equivalent dose: The equivalent dose ratio of propofol: etomidate is about 8.3:1; the equivalent dose of propofol in the mixture of group A is 14.4 mg / ml; the equivalent dose of propofol in the mixture of group B The concentration is 13.7mg / ml; the equivalent dose of propofol in group C mixture is 13.1mg / ml;

[0020] 1.3 Anesthesia: After the ...

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Abstract

The invention discloses a compound intravenous anesthetic which comprises propofol and etomidate according to a mass ratio of (2.5-5.5):1. The compound intravenous anesthetic disclosed by the invention is high-efficiency, safe, high in controllability, slight in adverse reaction and convenient in clinical application.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to a compound intravenous anesthetic. Background technique [0002] Propofol, whose chemical name is 2,6-diisopropylphenol, is a new type of rapid and short-acting intravenous anesthetic commonly used clinically for induction of anesthesia, maintenance of anesthesia, and sedation of critically ill patients in ICU. Propofol injection is a white isotonic intravenous injection, containing 10 mg of propofol per milliliter, and also contains refined soybean oil, refined egg yolk lecithin, glycerin and water for injection. This product is a short-acting intravenous anesthetic of alkyl phenols, which exerts sedative and hypnotic effects by activating the GABA receptor-chloride ion complex. At clinical doses, propofol increases chloride ion conduction and desensitizes GABA receptors at high doses, thereby inhibiting the central nervous system, producing sedative and hypnotic effects, and its anesthetic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K31/05A61P23/00
Inventor 陈希雨
Owner 陈希璇
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