Method for preparing bazhen granule by low-temperature continuous extraction combined with membrane separation technology

Abstract

The present invention provides a method for preparing bazhen granules by low-temperature continuous extraction combined with membrane separation technology, including the steps of: preparing traditional Chinese medicine decoction pieces of eight herbs including codonopsis pilosula and rhizoma atractylodis macrocephalae; mixing angelica sinensis, ligusticum wallichii and stir-bake rhizoma atractylodis macrocephalae, continuously extracting by ethanol at low temperature, recovering ethanol, decocting the dregs of angelica sinensis, ligusticum wallichii and stir-bake rhizoma atractylodis macrocephalae after continuous extraction at low temperature with water, decocting codonopsis pilosula, poria cocos, prepared rehmannia root and honey-fried licorice root with water, mixing the extracts, using an ultrafiltration membrane with a molecular weight cutoff of 8000-12000 for separation and purification, concentrating the liquid filtered by the membrane, standing, concentrating supernatant to an extract, adding accessories to the extract, and making into sugar-containing granules and sugar-free granules. The method is high in extraction efficiency, low in energy consumption, automatic in continuous operation; can remove the non-medicinal ingredients, at the same time keep medicinal ingredients well, is substantially reduced in extracted extract, solves the difficult problem of forming bazhen granules, and is stable in product quality and low in cost.

Description

Technical field: [0001] The invention relates to the preparation of Bazhen granules, in particular to a method for preparing Bazhen granules by continuous extraction at low temperature (50-70°C) combined with membrane separation technology. Background technique: [0002] Bazhen granules are composed of Codonopsis pilosula, fried Atractylodes macrocephala, Poria cocos, roasted licorice, angelica, fried white peony root, Chuanxiong, and rehmannia glutinosa. Bazhen granule has the function of invigorating qi and blood, and is used to treat deficiency of both qi and blood, pale complexion, loss of appetite, weakness of limbs, and menorrhagia. [0003] At present, there are some documents and patent reports on the preparation method of Bazhen granules. Chinese patent application: 98112016.4 discloses a preparation method of Bazhen sugar-free granules. This patent discloses a method for preparing sugar-free Bazhen Granules. In this method, Atractylodes Rhizoma Atractylodes Rhizom...

AI Technical Summary

Problems solved by technology

This method uses ethanol heating and reflux extraction, and the reflux extraction temperature is relatively high (generally 80-100°C), which easily destroys heat-sensitive components such as ferulic acid in Bazhen granules, thereby reducing the content of active components extracted; in addition, due to the use of The heating and reflux extraction method is added, so the energy consumption of production is increased, and the production cost is increased

In addition, this method is the method of ethanol heating and reflux extraction, decoction, extraction and filtration, direct concentration and adding excipients to make Bazhen granules. If less, it is easy to make preparations difficult to form, easy to absorb moisture and agglomerate to cause problems such as excessive moisture and unqualified properties, which makes the product quality unqualified, affects the industrial production of drugs, and is difficult to meet the needs of doctors and patients.

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