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Lifei tablet and preparing method of Lifei tablet

A Lifei tablet and a prescription technology, applied in the field of Lifei tablet and its preparation, can solve the problems such as difficulty in meeting the needs of doctors and patients, decrease in the concentration of effective parts of traditional Chinese medicine, influence on industrialized production of drugs, etc., so as to improve the bioavailability of drugs, The effect of potency enhancement and bioavailability enhancement

Inactive Publication Date: 2015-11-25
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method only improves the extraction process of Baibu, Wuzizi, Bai and these three herbs, and sees the improvement of other active ingredients, and uses equal concentration of ethanol to extract, and the extraction rate is still limited
[0005] In addition, the traditional method of heating ethanol to reflux extraction, decocting, extracting and filtering, directly concentrating and adding excipients to make Lifei Tablets, the prepared Lifei Tablets are due to the existence of some non-pharmacologically high relative molecular weight substances. The concentration of the effective part of traditional Chinese medicine is reduced, and the dosage is increased, which not only brings inconvenience and pain to the patient when taking it, but also makes the traditional Chinese medicine easy to absorb moisture and deteriorate, making it difficult to preserve
Affecting the industrial production of drugs, it is difficult to meet the needs of doctors and patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: Schisandra 54g Oyster 46g Lily 33g Baihe 112g Baibu 88g Cordyceps sinensis 4g Loquat leaf 42g Licorice 25g Gecko (1 million tablets 9 pairs)

[0029] (1) Pre-crushing the Cordyceps sinensis and Gecko in the prescription, mixing them for ultrafine grinding, passing through a 300-mesh sieve, and granulating to a particle size of 20-30 μm, generally no more than 50 μm;

[0030] (2) Ultrasonic water extraction and alcohol precipitation of loquat leaves, oysters, and licorice

[0031] Take the raw materials of loquat leaves, licorice and oysters in the prescribed amount, mix them, grind them into coarse powder, pass through a 40-mesh coarse sieve, and use ultrasonic enhancement to extract, use 15 times the amount of water as the extraction solvent, and perform ultrasonication for 1.5 hours at an ultrasonic frequency of 50KHz. The temperature is 40°C, filter, the filtrate is concentrated into an extract, add 95% ethanol to the extract until the ethanol concentra...

Embodiment 2

[0040] Prescription: Schisandra 54g Oyster 46g Lily 33g Baihe 112g Baibu 88g Cordyceps sinensis 4g Loquat leaf 42g Licorice 25g Gecko (1 million tablets 9 pairs)

[0041] Preparation:

[0042] (1) Pre-crushing the Cordyceps sinensis and Gecko in the prescription, mixing them for ultrafine grinding, passing through a 300-mesh sieve, and granulating to a particle size of 20-30 μm, generally no more than 50 μm;

[0043] (2) Ultrasonic water extraction and alcohol precipitation of loquat leaves, oysters, and licorice

[0044] Take the raw materials of loquat leaves, licorice and oysters in the prescribed amount, mix them and grind them into the coarsest powder, pass through a 40-mesh coarse sieve, use ultrasonic enhancement to extract, use 12 times the amount of water as the extraction solvent, and perform ultrasonication for 1.5 hours at an ultrasonic frequency of 40KHz. Ultrasonic temperature is 50°C, filter, the filtrate is concentrated into an extract, add 95% ethanol to the ...

Embodiment 3

[0053] Prescription: Schisandra 54g Oyster 46g Lily 33g Baihe 112g Baibu 88g Cordyceps sinensis 4g Loquat leaf 42g Licorice 25g Gecko (1 million tablets 9 pairs)

[0054] Preparation:

[0055] (1) Pre-crushing the Cordyceps sinensis and Gecko in the prescription, mixing them for ultrafine grinding, passing through a 300-mesh sieve, and granulating to a particle size of 20-30 μm, generally no more than 50 μm;

[0056] (2) Ultrasonic water extraction and alcohol precipitation of loquat leaves, oysters, and licorice

[0057] Take the raw materials of loquat leaves, licorice and oysters in the prescribed amount, mix them and grind them into the coarsest powder, pass through a 40-mesh coarse sieve, use ultrasonic enhancement to extract, use 10 times the amount of water as the extraction solvent, and perform ultrasonication for 1 hour at an ultrasonic frequency of 30KHz. The temperature is 60°C, filter, the filtrate is concentrated into an extract, add 95% ethanol to the extract un...

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Abstract

The invention discloses a preparing method of a Lifei tablet and a product prepared by the method. The Lifei tablet comprises the following ingredients including schisandra chinensis, ostrea gigas thunberg, lilies, bletilla striata, stemona japonica, cordyceps sinensis, loquat leaves, liquorice and geckoes. The preparing method comprises the following steps that: (1) the cordyceps sinensis and the geckoes are pulverized by an ultra-micro pulverization technology; (2) the ostrea gigas thunberg, the loquat leaves and the liquorice are subjected to ultrasonic water extraction and alcohol precipitation to obtain an extracting solution; (3) the schisandra chinensis, the lilies, the stemona japonica and the bletilla striata are subjected to continuous dynamic concentration ethanol extraction to obtain an extracting solution; (4) the extracting solutions obtained in the second step and the third step are subjected to centrifugal concentration, purification is performed by using a post-centrifugal membrane separation technology, and concentration is performed to obtain extractum; and (5), fine particles and the extractum are uniformly mixed to be prepared into particles, the drying is performed, auxiliary materials such as magnesium stearate and talcum powder are added, and tabletting is performed. The preparation process is optimized according to the properties of each medicine in the preparation. Compared with the prior art, the Lifei tablet prepared by the method has the advantages that the active ingredient content is increased, and the curative effect is prominent.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a Lifei tablet which has the functions of repelling tuberculosis and invigorating the lung, antitussive and expectorant and a preparation method thereof. Background technique [0002] The Lifei tablet involved in the present invention is composed of nine traditional Chinese medicines including Schisandra chinensis, oyster, lily, bletilla radix, hundred-bud, cordyceps sinensis, loquat leaf, licorice and gecko. Lifei Tablet has the effects of repelling tuberculosis and nourishing the lung, antitussive and expectorant. For pulmonary tuberculosis cough, expectoration of phlegm and hemoptysis, qi and blood asthma, chronic bronchitis, etc. [0003] The traditional preparation method is to take the above nine flavors, take 24g of white and gecko, oyster, cordyceps sinensis, hundred parts, and lily, and crush them into fine powder; filter, combine the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/28A61P11/00A61P11/14A61P11/06A61K35/618A61K35/583
Inventor 韩志强
Owner 韩志强
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