Taxol and cimetidine pharmaceutical composition

A technology of cimetidine and paclitaxel, which is applied in the field of medicine and can solve problems such as unresolved side effects

Inactive Publication Date: 2013-11-13
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The prior art has taught that paclitaxel can be used in combination with ranitidine, but th

Method used

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  • Taxol and cimetidine pharmaceutical composition
  • Taxol and cimetidine pharmaceutical composition
  • Taxol and cimetidine pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of paclitaxel for injection

[0047] prescription:

[0048]

[0049] making process

[0050] (1) Dissolve 50g of egg yolk lecithin, 40g of cholesterol, and 45g of Tween 80 in 2000ml of ethanol, mix well, and remove the ethanol under reduced pressure on a rotary thin film evaporator to obtain a phospholipid film;

[0051] (2) Add 2000ml of pH 6.0 phosphate buffer solution, shake and stir to completely hydrate the phospholipid membrane, then homogenize and emulsify with a tissue masher, filter with a 0.45μm microporous membrane to prepare a blank liposome suspension liquid;

[0052] (3) Dissolve 30 g of paclitaxel in 1000 ml of ethanol, filter through a 0.45 μm microporous membrane, add the filtrate to the blank liposome suspension, and stir at 60° C. for 60 minutes to obtain a paclitaxel liposome solution;

[0053] (4) Sterilize and filter the paclitaxel liposome solution with a 0.22 μm microporous membrane, and fill it;

[0054] (5) Freeze dr...

Embodiment 2

[0058] Example 2 Preparation of paclitaxel injection

[0059] prescription:

[0060]

[0061] making process

[0062] (1) First add 2000ml propylene glycol, 250ml povidone K30 and 30g Span 20 into the container, stir and mix well;

[0063] (2) Add 30g paclitaxel, stir to dissolve completely, add water for injection to 4500ml, adjust pH to 4.5 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0064] (3) Add 2.5g of activated carbon for injection, add the remaining water for injection, set the volume to 5000ml, stir and absorb for 30 minutes;

[0065] (4) The solution is decarbonized by coarse filtration, coarsely filtered through a 0.45 μm cartridge filter, and then sterilized and filtered with a 0.22 μm microporous membrane until the visible foreign matter is qualified;

[0066] (5) Fill, 5ml / bottle, seal, and sterilize to obtain paclitaxel injection.

Embodiment 3

[0076] Example 3 Preparation of Cimetidine Injection

[0077] prescription:

[0078]

[0079] making process:

[0080] (1) First add 1600ml of water for injection into the container;

[0081] (2) Add 300g of cimetidine, stir to dissolve completely, and adjust the pH to 5.7 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0082] (3) Add 1g of activated carbon for injection, add the rest of water for injection, set the volume to 2000ml, stir and absorb for 30 minutes;

[0083] (4) The solution is decarbonized by coarse filtration, coarsely filtered through a 0.45 μm cartridge filter, and then sterilized and filtered with a 0.22 μm microporous membrane until the visible foreign matter is qualified;

[0084] (5) Fill, 2ml / bottle, seal, sterilize, and get cimetidine injection.

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PUM

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Abstract

The invention relates to a taxol and cimetidine pharmaceutical composition, and particularly relates to a combined application package which comprises a taxol injection and a cimetidine-containing injection. When the taxol and cimetidine pharmaceutical composition is in use, cimetidine is subjected to intravenous injection before taxol treatment, and then the taxol is dissolved and diluted by normal saline or a 5% glucose and sodium chloride solution for intravenous drip infusion.

Description

technical field [0001] The invention relates to a pharmaceutical composition of paclitaxel and cimetidine, in particular to a combined application package of paclitaxel injection and the injection containing cimetidine, and belongs to the technical field of medicine. Background technique [0002] Paclitaxel is a new type of anti-microtubule drug, by promoting tubulin polymerization, inhibiting depolymerization, maintaining tubulin stability, and inhibiting cell mitosis. In vitro experiments have shown that paclitaxel has a significant radiosensitizing effect, which may cause cells to stop in the G2 and M phases that are sensitive to radiotherapy. [0003] Paclitaxel is a mitosis inhibitor or spindle poison (Spindle poison), and its mechanism of action is different from that of commonly used chemotherapeutic drugs. It induces and promotes the assembly of microtubules. Paclitaxel has the function of polymerizing and stabilizing microtubules, causing fast-dividing tumor cells ...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61P35/00A61K31/337
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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