Surface plasma resonance system and detection method thereof
A technology of surface plasmon and light detection, applied in the field of ion plasma resonance system and its detection, can solve the problem of small measurement range
Active Publication Date: 2013-11-13
山东深大光学科技有限公司
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[0004] The purpose of the embodiment of the present invention is to provide a surface plasmon resonance system, aiming to solve the problem of the small measurement range of the existing surface plasmon resonance system
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[0029] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0030] In the embodiment of the present invention, broadband light is generated first, narrowband light is obtained from the broadband light, and polarized light is obtained from the narrowband light to make it into modulated polarized light, and then the modulated polarized light is divided into probe light and reference light, so that The detection light is projected onto the sensing surface of the prism, and the detection light intensity distribution reflected by the sensing surface is recorded to form a detection image. During one modulation cycle of the detection light, the imaging mechanism a...
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The invention is suitable for the technical field of photoelectric detection, and provides a surface plasma resonance system and a detection method thereof. The surface plasma resonance system is composed of a detection light path and a reference light path. According to the invention, the detection light path is used for acquiring plurality sets of first detection images and second detection images under different narrowband optical wavelengths. Through searching for optimal narrowband optical wavelengths for various detection points of a sensing surface to produce SPR phenomenon from the plurality sets of first detection images and second detection images, a detection sample reflective index change is calculated, such that phase SPR high-sensitivity detection is completed. Both the plurality sets of first detection images and second detection images comprise SPR phase and spectral wavelength information. Through spectral scanning which is changing the narrowband optical wavelengths, a maximal dynamic range is obtained. Therefore, an application requirement of the surface plasma resonance system for large dynamic range is satisfied, and high sensitivity is ensured. Also, the surface plasma resonance system realizes plane detection which has extremely higher efficiency than that of point detection.
Description
technical field [0001] The invention belongs to the technical field of photoelectric detection, and in particular relates to a surface plasmon resonance system and a detection method thereof. Background technique [0002] Surface plasmon resonance (Surface Plasmon Resonance, SPR) is an emerging sensing technology, which has the advantages of high sensitivity, high throughput, easy to achieve specific detection and real-time, and does not require labeling, etc., and has been widely used in biological , medicine, food quality and safety, chemical and environmental monitoring and other industries, especially for online real-time detection of biomolecules such as DNA and protein, protein molecules, and drug-protein, nucleic acid-nucleic acid, antigen-antibody, receptor-ligand, etc. interactions between them, etc. [0003] At present, SPR technologies mainly include angle-type SPR, spectral-type SPR and phase-type SPR. Among them, the phase-type SPR sensing technology has higher...
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IPC IPC(8): G01N21/41G01N21/55
Inventor 邵永红顾大勇屈军乐牛憨笨
Owner 山东深大光学科技有限公司