Tamoxifen citrate enteric coated particles

A technology of tamoxifen and citric acid, applied in the direction of organic active ingredients, non-active ingredients of polymer compounds, anti-tumor drugs, etc., can solve the problem of low bioavailability

Active Publication Date: 2013-11-20
NANTONG GUANGTAI BIOCHEM PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcoming of low bioavailability of existing tamoxifen citrate preparations, the present invention has invented tamoxifen citrate inclusion compound enteric-coated granules

Method used

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  • Tamoxifen citrate enteric coated particles
  • Tamoxifen citrate enteric coated particles
  • Tamoxifen citrate enteric coated particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Prescription

[0032] Tamoxifen citrate inclusion compound: Tamoxifen citrate: α-cyclodextrin ratio is 1:2

[0033] Tamoxifen citrate inclusion compound 18 parts

[0034] The composition of lactose and mannitol (the weight ratio of the two is 6.7:3.3) 14 parts

[0035] Composition of micropowder silica gel and croscarmellose sodium (the weight ratio of the two is 2:7.5) 19 parts

[0036] 2 parts aspartame

[0037] Composition of hypromellose phthalate and cellulose acetate phthalate

[0038] (The weight ratio of the two is 1.3:3) 4 parts

[0039] Preparation:

[0040] 1. Prepare tamoxifen citrate inclusion compound according to the following method:

[0041] (1) In water or aqueous ethanol medium, react tamoxifen citrate with α-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until clarified, and separate the inclusion complex from the mixture thing; or

[0042] (2) In solid form, reacting tamoxifen cit...

Embodiment 2

[0046] Fully grind tamoxifen citrate and α-cyclodextrin described in Example 1 in 50% ethanol to form a uniform paste, and obtain a white powder after vacuum drying. Tamoxifen citrate increased 12-fold.

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Abstract

The invention relates to tamoxifen citrate enteric coated particles which are prepared by the following steps: firstly, preparing tamoxifen citrate into inclusion compounds; and then, preparing the enteric coated particles.

Description

technical field [0001] The present application relates to an enteric-coated granule, specifically, a tamoxifen citrate inclusion compound enteric-coated granule. Background technique [0002] Tamoxifen (TAM) is a non-steroidal compound approved by the US Food and Drug Administration in 1977 for the treatment of metastatic breast cancer in postmenopausal women. After nearly 30 years of application history, it is now also used to prevent the occurrence of breast cancer. TAM belongs to the first generation of selective estrogen receptor modulators (selective estrogen receptor modulators, SERMs), which have dual effects of estrogen agonism and estrogen antagonism, and this effect depends on different germlines, tissues and gene expression types, Different target organs or target cells have different effects. For example, TAM produces antagonizing estrogen in mammary gland tissue, while it produces estrogen agonizing effect in uterus and bone tissue. TAM competes with estrogen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/138A61K47/40A61P35/00
Inventor 李申李春涛邱俊
Owner NANTONG GUANGTAI BIOCHEM PROD
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