Local anesthesia pain-relieving time-delay agent

A technology of delaying agent and anesthesia, which is applied in the field of human and animal surgical anesthesia, can solve the problem of not meeting the requirements of analgesia, and achieve the effect of easy observation, easy mastery and fast onset.

Active Publication Date: 2013-11-20
李赴朝
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, even as long as 9 days of anesthesia and analgesia, it still cannot meet the requirements of some major postoperative analgesia

Method used

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  • Local anesthesia pain-relieving time-delay agent
  • Local anesthesia pain-relieving time-delay agent
  • Local anesthesia pain-relieving time-delay agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1—Excision of lipoma on the back

[0062] The composition ratio of the local anesthetic analgesic delay agent is:

[0063] Vitamin B Complex 10mg

[0064] (where VB 1 , VB 2 , VB 6 , VB 12 The weight ratio is 20:2:20:10)

[0065] Methylene blue 20mg

[0066] 5% sodium bicarbonate 5ml

[0067] Dexamethasone 10mg

[0068] Add the above ingredients into 15ml of 0.375% bupivacaine hydrochloride, add 0.9% normal saline to 30ml, and then use a 5 cm injection needle to inject layer by layer around the tumor body along the skin and subcutaneous tissue. The results obtained are: the onset time is 60 seconds, there is no pain during injection, and the anesthesia pain relief time lasts from 72 hours to 40 days. (The amount of bupivacaine required is reduced by one-fifth compared with the original amount, which improves the safety and quality).

Embodiment 2

[0069] Example 2—Indirect inguinal hernia repair

[0070] The composition ratio of the local anesthetic analgesic delay agent is:

[0071] Vitamin B Complex 15mg

[0072] (where VB 1 , VB 2 , VB 6 , VB 12 The weight ratio is 20:2:20:15)

[0073] Methylene blue 20mg

[0074] Sodium bicarbonate 5ml

[0075] Dexamethasone 20mg

[0076] Add the above ingredients to 20ml of 0.375% bupivacaine hydrochloride, add 0.9% normal saline to 40ml, and then use a 3 cm injection needle to inject into the skin and subcutaneous tissue layer by layer along the incision line. The results obtained are: the onset time is 60 seconds, there is no pain during injection, and the anesthesia pain relief time lasts from 72 hours to 40 days. (The amount of bupivacaine required is reduced by one-fifth compared with the original amount, which improves the safety and quality).

Embodiment 3

[0077] Embodiment 3——facial double eyelid surgery

[0078] The composition ratio of the local anesthetic analgesic delay agent is:

[0079] Vitamin B Complex 0.5mg

[0080] (where VB 1 , VB 2 , VB 6 , VB 12 The weight ratio is 10:2:10:10)

[0081] Methylene blue 10mg

[0082] Dexamethasone 10mg

[0083] 5% sodium bicarbonate 2ml

[0084] Add the above-mentioned components in proportion to 3ml of 1% prilocaine hydrochloride, add 0.1mg of 1% epinephrine hydrochloride, add 0.9% normal saline to 6ml, and then use a 2.5cm injection needle to perform subcutaneous injection on the eyelid of the patient , the result obtained is that the onset time of anesthesia is 60 seconds, the duration of analgesia is 40 days, and there is no pain during injection. (The amount of lidocaine required is reduced by one-fifth compared with the original amount, which improves the safety and quality).

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Abstract

A local anesthesia pain-relieving time-delay agent comprises: 0.5-20 mg of composite vitamin B, 10-20 mg of methylene blue, 10-100 mg of dexamethasone, 2-100 mL of a 5% sodium bicarbonate solution, and the balance 0.9% normal saline. The local anesthesia pain-relieving time-delay agent may also comprise 0.05-0.2 mg of hydrochloride adrenaline based on the need. The benefits comprise that: the local anesthesia pain-relieving time-delay agent is fast in effectiveness, only with 60 s; the local anesthesia pain-relieving time is long up to 30-40 days; no analgesic is needed after an operation, so that the risk of anaesthesia is reduced and security is improved; a patient subjected to the local anesthesia operation is conscious, and has no damaged central nerve and less-influenced whole body important function, and patient condition is easy to observe and control during operation; the patient is easy to nurse and transfer after the operation, manpower and material resources are saved, and the patient can easily recover physical ability after the operation; the amount of a local anesthesia medicine is reduced, and toxic and side effects are reduced; the local anesthesia pain-relieving time-delay agent is applied to subcutaneous or intramuscular injection in a local operation, the operation is simple and easy to grasp, so that the local anesthesia pain-relieving time-delay agent is applicable to vast grass-roots medical units; and the local anesthesia pain-relieving time-delay agent has a wide application scope comprising surgery, ophthalmology and otorhinolaryngology, gynaecology and obstetrics, plastics and aesthetic surgery and pain treatment department.

Description

technical field [0001] The invention relates to the field of anesthesia for human and animal operations, more specifically, a local anesthetic pain-relieving delay agent. Background technique [0002] At present, there are only two types of anesthesia options for various operations: general anesthesia or local anesthesia, referred to as general anesthesia or local anesthesia. [0003] General anesthesia—refers to a method of anesthesia that temporarily suppresses the patient's consciousness by extensively suppressing the central nervous system of the brain, so as to achieve the purpose of pain relief. However, general anesthesia requires a full-time anesthetist and proprietary anesthesia equipment. The operation is risky, the postoperative care is complicated, and the patient cannot take care of himself. [0004] Local anesthesia - only local medicine is used to block the sensory nerve conduction retrogradely, causing temporary loss of pain sensation in local tissues when t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61P23/02A61K31/573A61K31/5415A61K31/51A61K31/714A61K31/4415A61K31/525
CPCA61K31/4415A61K31/51A61K31/525A61K31/5415A61K31/573A61K31/714A61K33/00A61K9/0019A61P23/02A61K2300/00
Inventor 李赴朝
Owner 李赴朝
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