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Sodium potassium magnesium calcium and glucose injection and preparation method thereof

A glucose injection and glucose technology, applied in the field of sodium potassium magnesium calcium glucose injection and its preparation, can solve the problems of increased liver metabolism burden, respiratory depression, poisoning, etc., and achieve increased liver metabolism burden, strong buffering effect, and huge market The effect of capacity

Active Publication Date: 2014-12-03
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lactated Ringer's Injection has three deficiencies: first, the chloride ion is higher than the plasma content, the sodium ion is lower than the plasma content, and the osmotic pressure is also lower than the plasma. Dangerous patients are restricted to use; secondly, because lactic acid is rapidly metabolized into carbon dioxide and water by the liver, it can lead to metabolic alkalosis, cause postoperative respiratory depression, and increase the metabolic burden of the liver; thirdly, lactate is formed when it interacts with strong acid in the body Lactic acid, which interferes with the clinical use of lactic acid concentration as an indicator for monitoring the metabolism of body tissues

Method used

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  • Sodium potassium magnesium calcium and glucose injection and preparation method thereof
  • Sodium potassium magnesium calcium and glucose injection and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0019] Sodium Potassium Magnesium Calcium Glucose Injection, every 1000ml injection contains: 6.372g of sodium chloride, 0.30g of potassium chloride, magnesium chloride (MgCl 2 ·6H 2 O) 0.204g, sodium acetate (NaC 2 h 3 o 2 ) 2.052g, sodium citrate (C 6 h 5 Na 3 o 7 2H 2 O) 0.588g, calcium gluconate (C 12 h 22 CaO 14 ·H 2 (0) 0.672g, glucose 10g, and the water for injection of the remainder.

[0020] Preparation:

[0021] (1) Take 70°C water for injection with 80% of the liquid volume, add calcium gluconate and stir to dissolve, then add magnesium chloride, sodium chloride, potassium chloride, sodium acetate, and sodium citrate in sequence, and stir until it is colorless and clear get solution ;

[0022] (2) Add glucose to the solution , stirred until the solution was colorless and clear to obtain a solution ;

[0023] (3) Weigh the solution 0.5% activated carbon by weight, stir well and let it stand for 20 minutes, use a 0.45 μm microporous membrane to ...

Embodiment 2

[0027] Sodium Potassium Magnesium Calcium Glucose Injection, every 1000ml injection contains: 6.372g of sodium chloride, 0.30g of potassium chloride, magnesium chloride (MgCl 2 ·6H 2 O) 0.204g, sodium acetate (NaC 2 h 3 o 2 ) 2.052g, sodium citrate (C 6 h 5 Na 3 o 7 2H 2 O) 0.588g, calcium gluconate (C 12 h 22 CaO 14 ·H 2 (2) 0.672g, glucose 10g, L-leucine 0.25g, and the water for injection of the remainder.

[0028] Preparation:

[0029] (1) Take 70°C water for injection with 80% of the liquid volume, add calcium gluconate and stir to dissolve, then add magnesium chloride, sodium chloride, potassium chloride, sodium acetate, and sodium citrate in sequence, and stir until it is colorless and clear get solution ;

[0030] (2) Add glucose and L-leucine to the solution , stirred until the solution was colorless and clear to obtain a solution ;

[0031] (3) Weigh the solution 0.5% activated carbon by weight, stir well and let it stand for 20 minutes, use a 0...

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Abstract

The invention relates to sodium potassium magnesium calcium and glucose injection and a preparation method thereof. Each 1000ml of injection contains 6.372g of sodium chloride, 0.30g of potassium chloride, 0.204g of magnesium chloride (MgCl2.6H2O), 2.052g of sodium acetate (NaC2H3O2), 0.588g of sodium citrate (C6H5Na3O7.2H2O), 0.672g of calcium gluconate (C12H22CaO14.H2O) and 10g of glucose. The invention also provides a preparation method of the sodium potassium magnesium calcium and glucose injection. The preparation method comprises the following steps of: (1) adding calcium gluconate to water for injection, stirring and dissolving, then sequentially adding the magnesium chloride, the sodium chloride, the potassium chloride, the sodium acetate and the sodium citrate, and stirring; adding glucose and stirring; adding activated carbon, uniformly stirring, stewing, filtering by using a microporous membrane so as to remove carbon, refilling water for injection to full dose; sterilizing at 115 DEG C for 30 minutes, thus obtaining the sodium potassium magnesium calcium and glucose injection. The preparation is the high-capacity injection, does not need to be mixed when being used clinically, can be directly used for intravenous drip and is convenient to use clinically.

Description

technical field [0001] The invention relates to sodium potassium magnesium calcium glucose injection and a preparation method thereof. Background technique [0002] Factors such as surgery, trauma, burns, and hemorrhage can cause the loss of water and electrolyte components and the disturbance of the internal environment of the patient. Crystalloid infusion is required to supplement the reduction of functional extracellular fluid, correct metabolic acidosis and alleviate the disturbance of the internal environment. To some extent, especially in cardiac surgery, it is necessary to use crystalloid as a bypass priming fluid for extracorporeal bypass. In addition, water, electrolyte, and acid-base balance are closely related to each other. If it is too late to correct the disturbance of water, electrolyte, and acid-base balance, one kind of balance disorder will develop into multiple balance disorders. Therefore, an ideal crystalloid should be able to provide a strong buffer an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K9/08A61K47/18A61P3/02A61P3/12A61K33/06A61K31/7004A61K31/191A61K31/194A61K31/19
Inventor 黄毅熊骏宇陈敏张晓敏曾炎科吴忠虹
Owner ZHUHAI TONGYUAN PHARMA CO LTD