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A kind of medicinal composition containing ilaprazole and naproxen

A technology of composition and medicine, applied in the field of medicine

Active Publication Date: 2015-10-14
珠海保税区丽珠合成制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no compound preparation of ilaprazole and naproxen on the market, and the application of this patent can make up for this gap

Method used

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  • A kind of medicinal composition containing ilaprazole and naproxen
  • A kind of medicinal composition containing ilaprazole and naproxen
  • A kind of medicinal composition containing ilaprazole and naproxen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Ilaprazole and Naproxen Tablets

[0018] Prescription 1:

[0019]

[0020]

[0021] Preparation:

[0022] Pass ilaprazole, naproxen, microcrystalline cellulose, pregelatinized starch, and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol to make soft material, granulate with 20-mesh sieve, dry, 18-mesh Sieve and granulate, add magnesium stearate, after mixing evenly, adopt suitable punching die to press tablet, promptly obtain the ilaprazole and naproxen composite tablet that the weight ratio of ilaprazole and naproxen is 1:17.

Embodiment 2

[0023] Embodiment 2: Ilaprazole and Naproxen capsules

[0024] Prescription 2:

[0025]

[0026] Preparation:

[0027] Pass ilaprazole, naproxen and microcrystalline cellulose through 80-mesh sieve respectively, mix well, add 0.5% PVP-k30 ethanol solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 24-mesh sieve , add the talcum powder of recipe quantity, after mixing uniformly, pack into suitable capsule, obtain ilaprazole and naproxen compound capsule that the weight ratio of ilaprazole and naproxen is 1:17.

[0028] Example 3: Ilaprazole and Naproxen Chewable Tablets

[0029] Prescription 3

[0030]

[0031] Preparation:

[0032] Mix ilaprazole, naproxen, microcrystalline cellulose, and mannitol that have all passed through a 80-mesh sieve, use 0.5% PVP-K30 ethanol solution to make a soft material, granulate with a 16-mesh sieve, dry, and sieve with a 12-mesh sieve granules, add aspartame and orange essence, mix evenly, and press in...

Embodiment 4

[0033] Embodiment 4: Ilaprazole and Naproxen drop pills

[0034] Prescription 4

[0035]

[0036] Preparation:

[0037] Pass ilaprazole and naproxen through a 80-mesh sieve for later use: mix PEG6000 and S-40 and heat to about 60°C to melt, adjust the size of the dripper, use -25-5°C simethicone or The liquid paraffin is the cooling phase, dripping, filtering, washing, and selecting pills to obtain the ilaprazole-naproxen composite dropping pill with a weight ratio of 1:17.

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PUM

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Abstract

The invention provides a medicinal combination containing ilaprazole and naproxen. The combination is formed by utilizing the ilaprazole and naproxen as active ingredients to be mixed with pharmaceutically acceptable auxiliary materials. In the combination, the weight ratio of the ilaprazole to the naproxen is (1:10)-(1:30), preferably 1:16. The medicinal combination can be made into an oral liquid for treating patients suffering from rheumatoid arthritis, ostarthritis, ankylosing spondylitis and taking the risk of gastric ulcer relapse when non-steroid anti-inflammatory drugs are taken.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a medicinal composition containing ilaprazole and naproxen. Background technique [0002] Ilaprazole is the latest generation of proton pump inhibitor developed by Ilyang Pharmaceutical Co., Ltd. and Livzon Pharmaceutical Co., Ltd. in Korea. It is widely used in various acid-related gastrointestinal diseases, such as duodenal Ulcers, gastric ulcers, reflux esophagitis, etc. Compared with other PPIs, ilaprazole has the strongest antacid activity, no individual differences in treatment, and stronger acid control ability at night, etc., and is expected to become the core product in the PPI market. [0003] Naproxen is a non-steroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects, and works by inhibiting the synthesis of prostaglandins. NSAIDs are the most widely prescribed class of drugs in the world. Like most non-steroidal anti-inflamm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4439A61P1/04A61P29/00A61P19/02A61K31/192
Inventor 肖鸿侯雪梅金鑫于迎春张平汪伟明向双
Owner 珠海保税区丽珠合成制药有限公司