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Medicinal auxiliary material xanthan gum and preparation method thereof

A technology for pharmaceutical excipients and xanthan gum, which is applied in the field of preparation of xanthan gum for pharmaceutical excipients, can solve the problems of limited application range, late research and application, etc., and achieve reduced dissolution time, reduced energy consumption, and high pyruvic acid content Effect

Active Publication Date: 2014-12-10
JIANGSU SHENHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research and application of xanthan gum pharmaceutical excipients are late, there are still many disadvantages in product quality control, and the scope of application is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] a) preparation concentration is the mannitol aqueous solution of 200ppm;

[0033] b) under stirring, slowly add xanthan gum to the mannitol aqueous solution to prepare a xanthan gum solution with a concentration of 1% (g / ml);

[0034] c) slowly adding a sodium hydroxide solution with a mass concentration of 25% to the xanthan gum solution while stirring until the pH of the solution is 8;

[0035] d) Add calcium chloride to step c), the consumption of calcium chloride is 2.0% of xanthan gum quality, stir until calcium chloride is completely dissolved;

[0036] e) Add ethanol in the stirring state, so that the concentration of ethanol in the solution is 40%, and keep stirring for 30 minutes after adding ethanol, and precipitate filaments;

[0037] f) dehydrating the precipitated filaments;

[0038] e) Dry the dehydrated and separated filaments at a temperature of 55° C. and a vacuum of 0.02 to 0.10 MPa, and the drying weight of the dried material is 10%.

[0039] Produ...

Embodiment 2

[0042] a) preparation concentration is the mannitol aqueous solution of 3000ppm;

[0043] b) under stirring, slowly add xanthan gum to the mannitol aqueous solution to prepare a xanthan gum solution with a concentration of 5% (g / ml);

[0044] c) Slowly add a sodium hydroxide solution with a mass concentration of 20% to the xanthan gum solution while stirring until the pH of the solution is 10;

[0045] d) Add calcium chloride to step c), the consumption of calcium chloride is 6.0% of xanthan gum weight, stir until calcium chloride is all dissolved;

[0046] e) While stirring, add ethanol so that the concentration of ethanol in the solution is 75%, and continue stirring for 35 minutes after adding ethanol, and precipitate filaments;

[0047] f) dehydrating the precipitated filaments;

[0048] e) Dry the dehydrated and separated filaments at a temperature of 65°C and a vacuum of 0.02-0.10 MPa, and the drying weight of the dried material is 10.5%.

[0049] Product quality anal...

Embodiment 3

[0052] a) preparation concentration is the mannitol aqueous solution of 1500ppm;

[0053] b) under stirring, slowly add xanthan gum to the mannitol aqueous solution to prepare a xanthan gum solution with a concentration of 2.5% (g / ml);

[0054] c) Slowly add a sodium hydroxide solution with a mass concentration of 30% to the xanthan gum solution while stirring until the pH of the solution is 12;

[0055] d) add calcium chloride to step c), the consumption of calcium chloride is 3.5% of xanthan gum weight, stir until calcium chloride is all dissolved;

[0056] e) While stirring, add ethanol so that the concentration of ethanol in the solution is 65%, and continue stirring for 25 minutes after adding ethanol, and precipitate filaments;

[0057] f) dehydrating the precipitated filaments;

[0058]e) Dry the dehydrated and separated filaments at a temperature of 40°C and a vacuum of 0.02-0.10 MPa, and the drying weight loss of the dried material is 10.8%.

[0059] Product qualit...

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PUM

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Abstract

The invention discloses medicinal auxiliary material xanthan gum and a preparation method thereof. The xanthan gum is a medicinal auxiliary material xanthan gum product which is prepared from a food additive xanthan gum as a raw material by refining means such as dissolving by a mannitol water solution, adjusting pH by caustic soda liquid, salting out calcium chloride and the like. The xanthan gum prepared by the method disclosed by the invention has the characteristics of high viscosity and high pyruvic acid content; each quality index is significantly superior to those in provisions of the pharmacopoeia.

Description

technical field [0001] The invention belongs to the technical field of xanthan gum production, and relates to a preparation method of xanthan gum as a medicinal auxiliary material. Background technique [0002] In the United States, xanthan gum was approved for production by the Food and Drug Administration (FDA) in 1969, and included in the National Formulary (NF) in 1975. In 1985, the U.S. Food and Drug Administration considered that xanthan gum is non-toxic to the human body and has no stimulating effect on the skin and mucous membranes. [0003] At present, xanthan gum, as a pharmaceutical ingredient for intra-articular injection, has the advantages of good lubricity and special thixotropy characteristics, and can be used as an excellent carrier for controlled release of drugs, with a long-lasting effect in the intra-articular cavity. Xanthan gum can also limit the location of oral drug release, and inhibit the initial release rate of the drug to achieve colon-targeted ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36C08B37/00
Inventor 黄盟盟徐国华王英燕王希艳贾存江张芙蓉
Owner JIANGSU SHENHUA PHARMA