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Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system

A compound and imaging technology, applied in the introduction of acyclic/carbocyclic compound isotopes, the preparation of amino compounds, the preparation of organic compounds, etc., can solve the problems of signal intensity reduction, capture rate reduction, etc.

Inactive Publication Date: 2013-12-11
PIRAMAL IMAGING SA
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Problems solved by technology

According to reports, [ 11 C] Deuteration of amphetamine causes a decrease in the capture rate, leading to more reliable quantification of the signal
However, deuterated pairs observed in healthy baboons and human brain regions comparable to the ones we studied, such as the striatum, thalamus and cortex[ 11 C] The signal intensity reduction effect of D2 propargine (DED) is only about 1.2-2.0 times (Fowler et al., J. Neurochem 1988, 51: 1524-1534; J. Nucl. Med. 1995, 36: 1255-1262 ; Mol. Imaging Biol. 2005, 7:377-387)

Method used

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  • Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system
  • Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system
  • Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system

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Embodiment Construction

[0037] definition

[0038] As used herein, "leaving group" refers to a functional group selected from the group consisting of halogen, especially chlorine, bromine, iodine, methanesulfonyloxy, p-toluenesulfonyloxy, trifluoromethanesulfonyloxy Group, nonafluorobutanesulfonyloxy, (4-bromobenzene)sulfonyloxy, (4-nitrobenzene)sulfonyloxy, (2-nitrobenzene)-sulfonyloxy, (4-iso Propylbenzene)sulfonyloxy, (2,4,6-triisopropylbenzene)-sulfonyloxy, (2,4,6-trimethylbenzene)sulfonyloxy, (4-tert-butyl Benzene)sulfonyloxy, benzenesulfonyloxy and (4-methoxybenzene)sulfonyloxy.

[0039] When used herein by itself or as part of another group, the term "aryl" refers to a monocyclic ring containing 6 to 12 carbons in the ring portion, preferably 6-10 carbons in the ring portion Or a bicyclic aromatic group, such as phenyl, biphenyl, naphthyl or tetrahydronaphthyl. The preferred aryl group is phenyl.

[0040] When used herein in the specification and claims of the present invention, the term "alkyl"...

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Abstract

This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore, the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.

Description

Technical field [0001] The present invention relates to suitable for marking or has been 18 F-labeled new compounds, methods for preparing such compounds, compositions containing such compounds, kits containing such compounds or compositions, and such compounds, compositions or kits are used in positron emission tomography (PET) for applications in diagnostic imaging. Background technique [0002] In the fields of oncology, neurology, and cardiology, molecular imaging has the potential to detect disease, disease progression, or treatment effectiveness earlier than most conventional methods. Among several promising molecular imaging technologies that have been developed such as optical imaging, magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET), PET is due to its high sensitivity and The ability to provide quantitative and kinetic data is also particularly important for drug development. [0003] For example,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B59/00C07C209/16C07C211/29
CPCC07B59/001C07C211/29C07C209/16C07B59/00A61K51/04
Inventor 安德里·蒂勒乔治·克特绍托比阿斯·海因里希卢茨·莱曼克里斯特·哈尔丁桑格拉姆·纳格安德里·瓦罗内巴拉兹·古亚什
Owner PIRAMAL IMAGING SA
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