Surface-enhanced Raman scattering apparatus and methods

A surface-enhanced Raman and inner surface technology, applied in Raman scattering, devices for coating liquid on the surface, measuring devices, etc., can solve problems such as inappropriateness and trouble

Inactive Publication Date: 2013-12-11
IMRA AMERICA
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  • Application Information

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Problems solved by technology

However, these systems are not only cumbersome, but also not suitable for SERS because the cavity surface is only used for optical reflection

Method used

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  • Surface-enhanced Raman scattering apparatus and methods
  • Surface-enhanced Raman scattering apparatus and methods
  • Surface-enhanced Raman scattering apparatus and methods

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Embodiment Construction

[0057] As an example, Figure 16 Shown is the SERS spectrum of crystal violet, a widely used dye for showing SERS activity, obtained using a single SERS tube. Analytes were prepared as 10 ppm crystal violet in water. In the fabrication of SERS tubes, a colloidal solution of Au nanoparticles is first produced by femtosecond pulsed laser ablation of Au in a liquid solvent. The target was a sheet of metallic Au, and acetone was chosen as solvent because of its high volatility. During ablation, the target is immersed in acetone, and a colloid is formed directly in the acetone. The laser has a pulse energy of 10 microjoules, a pulse duration of 500 femtoseconds, and a repetition rate of 10 MHz. Notably, as previously discovered and disclosed in US Patent Application Serial No. 12 / 320,617, colloids can remain as stable suspensions for months without the need for additional stabilizing chemicals. The colloid was then injected into a glass tube with an inner diameter of 2 mm and a...

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Abstract

An apparatus for performing surface-enhanced Raman scattering (SERS) is disclosed, wherein an inner surface of a container is coated with SERS active materials such as nanoparticles of noble metals. The container can provide a partially enclosed, optical diffuse cavity. Inner surfaces of the optical diffuse cavity serve for dual purposes of enhancing Raman scattering of the contained analyte and optical integration, thereby improving the efficiency of optical excitation and signal collection. The container may be configured to isolate the SERS active material from the external environment. The container, which may be a cylindrical tube, may be referred to as a SERS tube. Methods of coating the inner wall of a container with pulsed laser ablation and with nanoparticle colloids, respectively, are disclosed.

Description

Field of Invention [0001] The present invention relates to surface-enhanced Raman scattering (SERS) for the detection of molecules, especially biomolecules. Background technique [0002] Surface-enhanced Raman scattering (SERS) is a sensitive analytical technique for the detection of specific molecules. In the SERS method, standard Raman scattering is enhanced by rough surfaces of metals such as gold, silver and copper. Specifically, nanoscale roughness (root mean square roughness between 10nm-100nm) on the order of tens of nanometers has the most significant enhancement effect. For this purpose, there are many methods for preparing substrates with nanoscale roughness. The most widely used nanoscale surface is that of colloidal nanoparticles. See, eg, Martin Maskovits, Surface-enhanced spectroscopy, Rev. Mod. Phys, 1985, Vol. 57, No. 3, p. 783; and Kneipp et al., Ultrasensitive chemical analysis by Raman spectroscopy, Chem. Rev. 1999 , Vol. 99, p. 2957. A convenient way...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01J3/44
CPCB05D3/06B05D7/22B82Y30/00B82Y40/00G01J3/44G01N21/658G01N2021/651G01N21/65
Inventor 刘冰钱卫村上真车勇
Owner IMRA AMERICA
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