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Enteral nutrition preparation capable of protecting intestinal mucosal barrier function injured by chemotherapy

A technology for nutritional preparations and chemotherapy damage, applied in food preparation, food science, applications, etc., can solve problems such as exacerbated immune function, mucosal barrier dysfunction, and increased permeability

Active Publication Date: 2013-12-18
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] About 90% of malignant tumor patients need chemotherapy during the whole course of treatment. While chemotherapy drugs kill tumor cells, they also have serious side effects on the digestive tract mucosa with active cell proliferation. "Intestinal tract is the central organ of stress" , inflammation, increased permeability, bacterial translocation, endotoxin infection, exacerbated immune function damage, leading to mucosal barrier dysfunction, seriously affecting the prognosis, reducing the quality of life, and affecting the development and outcome of the disease

Method used

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  • Enteral nutrition preparation capable of protecting intestinal mucosal barrier function injured by chemotherapy
  • Enteral nutrition preparation capable of protecting intestinal mucosal barrier function injured by chemotherapy
  • Enteral nutrition preparation capable of protecting intestinal mucosal barrier function injured by chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Example 1 Preparation of oyster polysaccharide

[0085] Shell the oysters and take the meat, wash and drain with distilled water, homogenate, add 4 times the volume of distilled water, and use ultrasonic pretreatment, the ultrasonic power is 800W, the temperature is 60°C, the ultrasonic time is 30min, and the ultrasonic time / intermittent time is 3 / 5 (s / s), then placed in a water bath shaking pot preheated to 55°C, adjusted the pH value to 8.0, added alkaline protease 3000U / g, after 4 hours of enzymolysis, inactivated the enzyme in a water bath at 100°C for 10 minutes, centrifuged at 1800 × g, Take the supernatant for 15 minutes, concentrate in vacuo, add absolute ethanol to adjust the ethanol content of the system to 30%, leave it at 4°C for 24 hours, and centrifuge to take the supernatant, add absolute ethanol to adjust the system ethanol degree to 60%, 4°C Stand still for 24 hours and centrifuge to take the precipitate, dry it in vacuum and grind it into powder, wh...

Embodiment 2

[0087] Example 2 Preparation of oyster polysaccharide

[0088] Shell the oysters and take the meat, wash and drain with distilled water, homogenate, add 6 times the volume of distilled water, use ultrasonic pretreatment, ultrasonic power is 900W, temperature is 50°C, ultrasonic time is 20min, ultrasonic time / intermittent time is 3 / 5 (s / s), then placed in a water bath shaking pot preheated to 45°C, adjusted the pH value to 8.0, added trypsin 3000U / g, after 6 hours of enzymolysis, inactivated the enzyme in a water bath at 100°C for 10 minutes, centrifuged at 1800 × g, 15 Take the supernatant in 1 min, concentrate in vacuo, add absolute ethanol to adjust the ethanol content of the system to 30%, leave it at 4°C for 24 hours, centrifuge to take the supernatant, add absolute ethanol to adjust the system ethanol degree to 60%, and stand at 4°C Centrifuge for 24 hours to take the precipitate, dry it in vacuum and grind it into powder, which is the oyster polysaccharide component s...

Embodiment 3

[0090] Example 3 Preparation of enteral nutrition powder

[0091] Fresh oysters are shelled to take the meat, washed with distilled water, drained, homogenized, added with 6 times the volume of distilled water, and pretreated with ultrasonic waves. The ultrasonic power is 800W, the temperature is 60°C, the ultrasonic time is 30min, and the ultrasonic time / interval time is 3 / 5 (s / s), then placed in a water bath shaking pot preheated to 55°C, adjusted the pH value to 8.0, added alkaline protease 3000U / g, enzymatically hydrolyzed for 4h, inactivated the enzyme in a water bath at 100°C for 10min, and centrifuged at 1800 × g , 15 minutes to take the supernatant, vacuum concentration to 15% solid content, keep warm in 50 ℃ water bath, add premixed olive oil, fish oil and medium chain triglycerides while stirring, then add maltodextrin 10% , stirring and dissolving homogeneously until the material liquid is uniform without oil droplets, spray drying to make powder, the conditions...

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Abstract

The invention belongs to the field of food production, and particularly relates to an enteral nutrition preparation capable of protecting intestinal mucosal barrier function injured by chemotherapy. The nutrition preparation contains oyster polysaccharides. The oyster polysaccharides are prepared by the following steps: washing oyster meat, homogenating, adding water for performing ultrasonic treatment, adding protease for performing enzymolysis, then adding ethanol for precipitating to obtain oyster polysaccharides. The oyster polysaccharides component which have obvious activities of resisting oxidization, enhancing immunity and promoting proliferation of intestinal epithelial cells are screened through cell activity, are used as immune nutrients to be applied to enteral nutrition preparation, and are used for development of an enteral nutrition preparation capable of recovering and maintaining the intestinal mucosal barrier function injured by chemotherapy and improving prognosis of tumor patients. According to the enteral nutrition preparation, the nutrient substances are reasonably proportioned according to the physiological metabolism of the tumor patients so as to design and develop the enteral nutrition preparation which has the effects of recovering and maintaining the intestinal mucosal barrier function injured by chemotherapy and improving the prognosis of tumor patients.

Description

technical field [0001] The invention belongs to the field of food production, and in particular relates to an enteral nutrition preparation for protecting the barrier function of the intestinal mucosa damaged by chemotherapy. Background technique [0002] About 90% of malignant tumor patients need chemotherapy during the whole course of treatment. While chemotherapy drugs kill tumor cells, they also have serious side effects on the digestive tract mucosa with active cell proliferation. "Intestinal tract is the central organ of stress" , Inflammation, increased permeability, bacterial translocation, endotoxin infection, exacerbated immune function damage, leading to mucosal barrier dysfunction, seriously affecting prognosis, reducing quality of life, and affecting disease progression and outcome. The intestinal mucosal barrier is the body's first line of immune defense and constitutes the largest interface between the human body and the external environment. The normal intest...

Claims

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Application Information

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IPC IPC(8): A23L1/09C08B37/00A23L33/125
Inventor 蔡冰娜潘剑宇孙恢礼陈华万鹏陈得科
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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