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Acyclovir capsule preparation and preparation method thereof

A preparation and capsule technology, applied in the field of medicine, can solve the problems of large amount of sustained-release materials, poor release consistency, and reduce production costs, and achieve the effect of zero-order drug release, low production costs, and fewer types of excipients

Inactive Publication Date: 2013-12-25
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patented process adopts ordinary wet granulation, so the amount of sustained-release materials is relatively large; the release consistency is poor, which may easily cause sudden or uneven drug release
[0004] In summary, there are many types of technical auxiliary materials for preparing acyclovir capsules, and the consumption is large, which is not conducive to reducing production costs

Method used

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  • Acyclovir capsule preparation and preparation method thereof
  • Acyclovir capsule preparation and preparation method thereof
  • Acyclovir capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] Preparation Process:

[0021] Prescription amount Weigh acyclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose, add to ethanol, stir to dissolve, add to liquid paraffin containing 0.5% (v / v) Span 80 under stirring conditions , gradually raised the temperature to 40°C, kept stirring for 6 hours, raised the temperature to 70°C, stirred for 1 hour, and filtered under reduced pressure to obtain acyclovir sustained-release pellets, which were filled into capsule shells.

Embodiment 2

[0023]

[0024] Preparation Process:

[0025] Prescription quantity Weigh acyclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose, add it to ethanol, stir to dissolve, and add it to liquid paraffin containing 2% (v / v) Span 80 under stirring conditions , gradually raised the temperature to 40°C, kept stirring for 6 hours, raised the temperature to 70°C, stirred for 1 hour, and filtered under reduced pressure to obtain acyclovir sustained-release pellets, which were filled into capsule shells.

Embodiment 3

[0027]

[0028]

[0029] Preparation Process:

[0030] Prescription amount Weigh acyclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose, add to ethanol, stir to dissolve, add to liquid paraffin containing 0.5% (v / v) Span 80 under stirring conditions , gradually raised the temperature to 40°C, kept stirring for 6 hours, raised the temperature to 70°C, stirred for 1 hour, and filtered under reduced pressure to obtain acyclovir sustained-release pellets, which were filled into capsule shells.

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Abstract

The invention discloses an acyclovir capsule preparation. The acyclovir capsule preparation comprises a capsule shell and content, wherein the content is an acyclovir sustained-release pellet, and the acyclovir sustained-release pellet is prepared by the following steps of dissolving acyclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose in ethyl alcohol, adding into liquid paraffin containing surfactant while stirring, gradually heating up to 38-42 DEG C, keeping warm and stirring for 4-8 hours, heating up to 68-72 DEG C, stirring for 0.5-2 hours, and filtering under diminished pressure, thereby obtaining the acyclovir sustained-release pellet. According to the acyclovir capsule preparation, the dosage of the sustained-release material is greatly reduced, and the phenomenon of initial burst release of the medicine is eliminated.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antiviral drug preparation, in particular to an acyclovir capsule preparation and a preparation method thereof. Background technique [0002] Acyclovir is a synthetic purine nucleoside analogue. It is mainly used for various infections caused by herpes simplex virus, and can be used for initial or recurrent skin, mucous membrane, external genital infection and HSV infection in immunocompromised persons. It is the drug of choice for the treatment of HSV encephalitis, and it is superior to adenosine vidarabine in reducing morbidity and mortality. It can also be used for herpes zoster, Epstein-Barr virus, and immunodeficiency complicated by chickenpox and other infections. For topical use on the skin only, acyclovir has less skin absorption. [0003] CN 101502521B discloses a group of acyclovir sustained-release preparation compositions and a preparation method th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/522A61K47/38A61P31/22
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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