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Slit waveguide based pathogen detection sensor

A pathogen detection and slit waveguide technology, applied in the field of pathogen detection, can solve the problems of high cost, complex structure, large size, etc., and achieve the effect of high integration, obvious change of light field, and rapid change of light field

Active Publication Date: 2015-04-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of the existing pathogen detection technology, such as complex structure, large size, and high cost, the present invention provides a slit-based waveguide that simplifies the structure, reduces the size, and reduces the cost while meeting high detection efficiency and fast response. pathogen detection sensor

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  • Slit waveguide based pathogen detection sensor

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Embodiment 1

[0025] Referring to Fig. 1, a pathogen detection sensor based on a slit waveguide includes a detection part, and the detection part includes a virus detection component, and the virus detection component includes straight waveguides arranged side by side up and down, and the narrow gap between the adjacent up and down straight waveguides The slit area is a slit waveguide, the width of the slit waveguide is 175nm-225nm, the antigen / antibody of the virus to be detected is attached to the side wall of the slit waveguide, and the slit waveguide is used for the blood sample to be detected to flow through. In the detection channel, the refractive index of the straight waveguide material is higher than that of the slit waveguide.

[0026] Further, the sensor also includes an outgoing part, the outgoing part includes a bus waveguide, a photoelectric conversion module and an information upload module, the optical field signal output end of the slit waveguide is connected to the bus wave...

Embodiment 2

[0040] Referring to Figures 2 to 5, on the basis of Embodiment 1, the blood glucose concentration detection function is added; the detection part also includes a blood glucose detection component, and the blood glucose detection component is composed of a straight waveguide and a microring waveguide, the The slit area between the straight waveguide and the microring waveguide is an area surrounded by a straight line and an arc. The shortest distance between the straight line and the arc is located on a straight line passing through the center of the arc and perpendicular to the straight line. Set the straight line and the arc The shortest distance between them is between 50-80nm, the slit area is an annular slit waveguide, and the annular slit waveguide is a detection channel for the blood sample to be detected to flow through, and the refractive index ratio of the straight waveguide material is The refractive index of the annular slot waveguide is high.

[0041] One straight ...

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Abstract

A slit waveguide based pathogen detection sensor comprises a detection part, the detection part comprises a virus detection assembly, the virus detection assembly comprises straight waveguides which are arranged side by side up and down, a slit area between adjacent upper and lower straight waveguides is a slit waveguide, the width dimension of the slit waveguide is 175-225nm, a sidewall of the slit waveguide is attached with antigens / antibodies of viruses for detection, the slit waveguide is a detection channel for the flow of a blood sample for detection, and the refractive index of the material of the straight waveguides is higher than the refractive index of the slit waveguide. The slit waveguide based pathogen detection sensor provided by the invention has the advantages of high detection efficiency, fast response, simplified structure, reduced dimension and reduced cost.

Description

technical field [0001] The invention relates to the field of pathogen detection, in particular to a pathogen detection sensor. Background technique [0002] In the existing pathogen detection technology, the conventional pathogen detection is invasive detection, and the medical treatment is slow, the efficiency is low, and the intelligence is not high. [0003] Someone proposed to use genetic technology to detect pathogens, for example, the patent application number is 200680050988.6, and the title of the invention is: Chinese invention patent application for the method of detecting pathogens; another person proposed to use up-conversion luminescence technology to realize pathogen detection, for example, the patent number is: 200410034105.5, The Chinese invention patent of the invention name is up-conversion luminescent biosensor. [0004] Using genetic technology to detect pathogens has high detection accuracy, but there are technical defects: the entire detection equipmen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/569G01N21/41
Inventor 乐孜纯李塘林宣怀
Owner ZHEJIANG UNIV OF TECH
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