Irradiation crosslinked chitosan/gelatin/polyvinyl alcohol hydrogel dressing as well as preparation method and application thereof

Abstract

The invention discloses an irradiation crosslinking chitosan / gelatin / polyvinyl alcohol hydrogel dressing as well as a preparation method and an application thereof. The preparation method comprises the steps that a chitosan, gelatin and polyvinyl alcohol solution is prepared by using ultrapure water serving as a solvent; the solution is stirred and mixed uniformly and then irradiated, and original hydrogel is obtained; the original hydrogel is put into the ultrapure water to be soaked; and the chitosan / gelatin / polyvinyl alcohol hydrogel dressing is prepared. The hydrogel dressing is extensive in raw material source, simple in preparation technology and stable in performance, and has the advantages of inflammation diminishing, wound pain relieving, scar reduction, wound healing promotion, wound seepage absorption, and excellent biocompatibility. The hydrogel dressing is easy to degrade after abandoned, and has a smaller influence on an environment. The hydrogel dressing can be applied to the fields of trauma hemostasis, inflammation diminishing, scald, postoperative wound healing and the like.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to an irradiation crosslinked chitosan / gelatin / polyvinyl alcohol hydrogel dressing, its preparation method and its application in medical treatment. Background technique [0002] Dressing is an essential medical product. The combination of sterile gauze and topical antibiotics is the traditional dressing. However, in traditional dressings, the gauze is easy to adhere to the skin wound tissue. Changing the dressing often destroys the new epithelium and granulation tissue, causing bleeding, which is not conducive to wound healing. , and cause unbearable pain to the patient. The hydrogel dressing has excellent physical and biocompatibility, sticks to the wound, does not adhere to the wound, does not destroy new tissue, and can kill a variety of bacteria and avoid wound infection. Compared with traditional dressings, hydrogel dressings can promote better wound heali...

AI Technical Summary

Problems solved by technology

CN27724714 discloses " hydrogel chitosan medical dressing ", and it is beneficial to wound absorption, promotes wound healing, has better effects such as hemostasis, anti-inflammatory pain relief, healing cicatrix; But its composition is single, strength, toughness and absorption permeability There are deficiencies in liquid capacity, etc.

CN102895699 discloses "a composite hydrogel dressing for skin wound repair", the main components of which are hyaluronic acid and type I collagen, cross-linked by sodium trimetaphosphate, and the cross-linked product is rinsed and soaked in deionized water, A clean hydrogel dressing can only be obtained by removing impurities such as cross-linking agents and alkalis; although the hydrogel dressing can quickly promote skin wound healing, the residual impurities make it poor in antibacterial, anti-inflammatory and hemostatic properties

CN101337086A discloses "a hydrogel dressing and its preparation method", which is composed of upper and lower layers. The upper and lower layers of hydrogel are prepared by radiation method and freeze-thaw radiation method respectively. Since they contain water-soluble polymers, their It has excellent strength, toughness, transparency and the ability to absorb wound exudate; however, the preparation process of the hydrogel dressing is complicated and difficult to produce on a large scale

In addition, hydrogel dressings have the disadvantages of low swelling and weak ability to absorb wound exudate, so they must be replaced many times, which increases the cost of treatment and is not conducive to the rapid healing of wounds