Chiral catalyst in binaphthol synthesis technology

Abstract

A chiral catalyst in a binaphthol synthesis technology is a 1,2-cyclohexanediamino-2-(3-hydroxy-2-naphthalenone)Schiff base-ferric iron complex, and the 1,2-cyclohexanediamino-2-(3-hydroxy-2-naphthalenone)Schiff base is generated through reacting (1R,2R) or (1S,2S)1,2-cyclohexanediamine with 3-hydroxy-2-naphthalenone. The structural formula of the chiral catalyst is shown in the specification. Cheap ferric iron same with the center ligand of the catalyst is adopted as an oxidant to carry out a chiral catalytic reaction, and the adoption metal ions as an oxidant can guarantee the high conversion rate of a product; the catalyst does not react with the oxidant to form impurities in a catalyst and oxidant recovery process, so a recovery step is simplified, and the recovery feasibility of the catalyst is improved; and the recycle of the catalyst and the oxidant can guarantee a high optical purity of the product, a high conversation rate and a high optical purity can be realized on the basis of a low cost, the pressure to the environmental protection is reduced, and the green chemistry is realized.

Description

technical field

[0001] The invention relates to the field of asymmetric catalytic synthesis, in particular to a chiral catalyst in the binaphthol synthesis process. Background technique

[0002] In organic chemistry, some compounds have the same molecular weight and the same molecular structure, but the left and right arrangements are opposite, just like the real object and its mirror image, and like two hands that cannot overlap each other, so these compounds are called chiral compounds. A chiral compound must have optical activity, and the racemate of an optically active chiral compound has two enantiomers. This enantiomer is formed by mixing optical isomers with opposite optical rotation directions and the same optical rotation ability. The optical activity of the racemate cancels each other due to the interaction between the optical isomers, so the racemate is not optically active.

[0003] The chirality of the compound determines that the compound has some physical p...