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A kind of ginkgo biloba extract pellets and preparation method thereof

A technology of extract and ginkgo biloba, applied in the field of ginkgo biloba extract pellets and preparation, can solve the problem of low dissolution rate, achieve good bioavailability, easy to swallow, and great application value

Active Publication Date: 2016-04-20
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese Pharmacopoeia has included quality standards for ginkgo leaf extract tablets, capsules, and dripping pills. , generally no dissolution requirements
The dissolution rate can better evaluate the therapeutic effect of the drug in vitro. Usually, the drug requires a dissolution rate of more than 80% in 30 minutes, and the dissolution rate of the existing Ginkgo biloba extract drop pills is relatively low.

Method used

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  • A kind of ginkgo biloba extract pellets and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Ginkgo biloba extract 100g polyvinyl alcohol 16g Neotame 1g lemon zest 5g Microcrystalline Cellulose Blank Ball Core 500g 95% ethanol 500g purified water 94g

[0026] ;

[0027] Preparation: Ginkgo biloba extract is dissolved in 95% ethanol, and neotame and lemon essence are added to make a liquid; polyvinyl alcohol is added with water to make a suspension, and the above liquid is added under constant stirring to form a suspension, and stirred evenly Afterwards, the fluidized bed is operated, the fluidized bed model is DPC-ⅡA, the atomization pressure is 0.40bar, the inlet temperature is 36-40°C, and the flow rate of the suspended drug solution is 1.5g / min, so that the suspended drug solution is evenly adsorbed on the surface of the blank core , At the same time, ethanol was removed, and dry, uniform and stable ginkgo biloba extract pellets were obtained, with a total of 1250 dosage units.

Embodiment 2

[0029] Ginkgo biloba extract 100g polyvinyl alcohol 10g Neotame 0.5g lemon zest 3g blank core 400g 95% ethanol 400g purified water 75g

[0030] ;

[0031] Preparation: Ginkgo biloba extract is dissolved in 95% ethanol, and neotame and lemon essence are added to make a liquid; polyvinyl alcohol is added with water to make a suspension, and the above liquid is added under constant stirring to form a suspension, and stirred evenly Afterwards, the fluidized bed is operated, the fluidized bed model is DPC-ⅡA, the atomization pressure is 0.40bar, the inlet temperature is 36-40°C, and the flow rate of the suspended drug solution is 1.5g / min, so that the suspended drug solution is evenly adsorbed on the surface of the blank core , At the same time, ethanol was removed, and dry, uniform and stable ginkgo biloba extract pellets were obtained, with a total of 1250 dosage units.

Embodiment 3

[0033] Ginkgo biloba extract 100g polyvinyl alcohol 20g Neotame 2g lemon zest 8g blank core 600g 95% ethanol 550g purified water 103g

[0034] Preparation: Ginkgo biloba extract is dissolved in 95% ethanol, and neotame and lemon essence are added to make a liquid; polyvinyl alcohol is added with water to make a suspension, and the above liquid is added under constant stirring to form a suspension, and stirred evenly Afterwards, the fluidized bed is operated, the fluidized bed model is DPC-ⅡA, the atomization pressure is 0.40bar, the inlet temperature is 36-40°C, and the flow rate of the suspended drug solution is 1.5g / min, so that the suspended drug solution is evenly adsorbed on the surface of the blank core , At the same time, ethanol was removed, and dry, uniform and stable ginkgo biloba extract pellets were obtained, with a total of 1250 dosage units.

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Abstract

The invention provides a ginkgo leaf extract pellet and a preparation method thereof. The ginkgo leaf extract pellet consists of the following components in parts by mass: 100 parts of ginkgo leaf extract, 10-30 parts of polyvinyl alcohol, 2-12 parts of a taste masking agent, 400-700 parts of microcrystalline cellulose blank pellet core, 300-1000 parts of 95% alcohol and 50-200 parts of pure water. The preparation method comprises the following steps: adding the ginkgo leaf extract and the taste masking agent into the 95% alcohol, and sufficiently stirring uniformly to prepare medical liquor; adding the polyvinyl alcohol into the pure water and stirring to prepare a suspension; mixing the medical liquor with the suspension, and sufficiently stirring to prepare suspended medical liquor; and obtaining the ginkgo leaf extract pellet through fluidized bed operation. The ginkgo leaf extract pellet disclosed by the invention does not contain sugar or starch, is easy to swallow, has dissolution rate exceeding 90% within 30 minutes in a plurality of dissolving media, better bioavailability and good mouthfeel, and is especially suitable for elder population, and the population with low sugar tolerance or diabetic population. The microcrystalline cellulose blank pellet is not digested by a human body and finally exhausted out of the body, does not have influences on pesticide effect and is larger in application value. Besides, the ginkgo leaf extract pellet is simple in formula, convenient in process and suitable for production.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a ginkgo leaf extract pellet and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba plant, the main chemical components are flavonoids and terpenoid lactones, which have important medicinal value and market value. Therefore, many ginkgo biloba products have been developed. At present, the preparations of ginkgo leaf extract are mainly tablets, capsules, dripping pills, dispersible tablets, granules, etc. Most of these products contain sugar, starch, gelatin and other auxiliary materials, which are not suitable for people with low glucose tolerance or diabetes. The Chinese Pharmacopoeia has included quality standards for ginkgo leaf extract tablets, capsules, and dripping pills. , generally no dissolution requirements. The dissolution rate can better evaluate the therapeutic effect of the drug in vitro. Usually, the drug requires ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/16A61K47/42A61K47/46A61K47/32
Inventor 于垂亮梅锦平孙蓉肖志勇
Owner SHANGHAI SINE PROMOD PHARMA