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Application of combination of tacrolimus and fluconazole in preparing antifungal drugs
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An antifungal drug, tacrolimus technology, applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc. active effect
Inactive Publication Date: 2014-01-22
QIANFOSHAN HOSPITAL OF SHANDONG
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However, there is no large-scale quantitative study on whether the combination of FK506 and FLC can reverse the resistance of non-albicans to FLC.
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[0018] Experimental strain: clinically isolated non-albicans Candida, identified and confirmed by CHROMagar chromogenic identification medium, subcultured on solid medium. The numbers of Candida glabrata are CG1, CG2, CG3, CG4, CG5, and CG8, and the numbers of Candida krusei are CK2, CK3, CK4, CK6, CK7, CK8, CK9, and CK10.
[0065] The strains used in the experiment were clinically isolated Candida glabrata CG4 and Candida krusei CK4, which were identified and confirmed by CHROMagar yeast identification medium and subcultured on solid medium.
[0066] 1.2 Drugs and reagents
[0067] FLC and FK506 raw materials; dimethyl sulfoxide DMSO; PBS buffer; 0.1mol / L NaOH solution; CHROMagar chromogenic medium (France); RPMI1640 (GIBCO, the United States, containing L-glutamine, without carbonic acidSodiumhydrogen, adjust the pH to 7.0 with MOPS buffer); Yeast extract-peptone-glucose (YPD) agar medium.
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Abstract
The invention discloses application of combination of tacrolimus and fluconazole in preparing antifungal drugs. According to the invention, static and dynamic combined antifungal effects of combination of tacrolimus and fluconazole to common non-albicans candida species are researched by various methods. The researches show that combination of tacrolimus and fluconazole has a remarkable synergic antifungal effect to common non-albicans candida species (candida glabrata and candida krusei). Predictably, combination of tacrolimus and fluconazole can be used for preparing antifungal drugs. According to the invention, tacrolimus and fluconazole are applied in a combined way to enhance the antimicrobial activity of fluconazole to non-albicans candida species so as to generate the synergic antifungal effect. Combination of tacrolimus and fluconazole can reverse the drug resistance of non-albicans candida species to fluconazole, thereby providing a research direction for development of new drugs and new use of old drugs.
Description
technical field [0001] The invention relates to the application of tacrolimus combined with fluconazole in the preparation of antifungal drugs. Background technique [0002] With the increasing number of cancer and AIDS patients, the widespread development of organ transplantation, catheterintubation and endoscopic techniques, the wide application of high-efficiency broad-spectrum antibiotics, FK506 and hormones, the incidence of deep fungal infections in humans has increased year by year, and fungi have become important pathogens of nosocomial infections. Candida albicans is a common isolate in clinical fungal infections, and fluconazole (FLC) is effective against it. However, with the widespread clinical application of FLC, non-Candida albicans species that are not sensitive to it, such as Candida glabrata (CG), Candida tropicalis, and Candida krusei (CK) ), Candida parapsilosis, etc., the isolation rate gradually increased, and more and more non-albicans were isolated ...
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