Application of combination of tacrolimus and fluconazole in preparing antifungal drugs

An antifungal drug, tacrolimus technology, applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc. active effect
CN103520157AInactive Publication Date: 2014-01-22QIANFOSHAN HOSPITAL OF SHANDONG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QIANFOSHAN HOSPITAL OF SHANDONG
Publication Date
2014-01-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of combination of tacrolimus and fluconazole in preparing antifungal drugs. According to the invention, static and dynamic combined antifungal effects of combination of tacrolimus and fluconazole to common non-albicans candida species are researched by various methods. The researches show that combination of tacrolimus and fluconazole has a remarkable synergic antifungal effect to common non-albicans candida species (candida glabrata and candida krusei). Predictably, combination of tacrolimus and fluconazole can be used for preparing antifungal drugs. According to the invention, tacrolimus and fluconazole are applied in a combined way to enhance the antimicrobial activity of fluconazole to non-albicans candida species so as to generate the synergic antifungal effect. Combination of tacrolimus and fluconazole can reverse the drug resistance of non-albicans candida species to fluconazole, thereby providing a research direction for development of new drugs and new use of old drugs.
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Description

technical field

[0001] The invention relates to the application of tacrolimus combined with fluconazole in the preparation of antifungal drugs. Background technique

[0002] With the increasing number of cancer and AIDS patients, the widespread development of organ transplantation, catheter intubation and endoscopic techniques, the wide application of high-efficiency broad-spectrum antibiotics, FK506 and hormones, the incidence of deep fungal infections in humans has increased year by year, and fungi have become important pathogens of nosocomial infections. Candida albicans is a common isolate in clinical fungal infections, and fluconazole (FLC) is effective against it. However, with the widespread clinical application of FLC, non-Candida albicans species that are not sensitive to it, such as Candida glabrata (CG), Candida tropicalis, and Candida krusei (CK) ), Candida parapsilosis, etc., the isolation rate gradually increased, and more and more non-albicans were isolated ...

Claims

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