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Preparation method of Chinese medicine mixture

A technology of mixtures and traditional Chinese medicines, which is applied in the directions of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., which can solve the research difficulty and production inconvenience of researchers, unqualified baicalin content in finished products, and unstable product quality between batches, etc. Problems, to achieve the common equipment and material conditions, easy to obtain equipment and material conditions, improve the quality and efficacy of the effect

Active Publication Date: 2014-01-22
HAINAN HONZ PHARMA +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the actual production research, the inventor found that the original process parameters were not clear, and the transfer rate of baicalin in the production link was only 20%-40% when the production was carried out according to the conventional method, which caused the unqualified content of the finished product baicalin to occur easily. Excessive density (exceeding the standard), waste of resources caused by excessive requirements on raw material quality, unstable product quality between batches, etc., so the current process must be improved
In production, there are many factors that affect the transfer rate of baicalin and the relative density of the preparation, including extraction solvent, pH value, temperature, process time, etc., and there are multiple interactions, especially the factors that affect the transfer rate of baicalin and the relative density of the preparation are often There is a reverse correlation. On the basis of the standard process, it is difficult to take into account the content of baicalin and the relative density to reach the standard at the same time by adopting the conventional process of simply increasing the transfer rate of baicalin or reducing the relative density of the preparation. Great research difficulty and inconvenience in production

Method used

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  • Preparation method of Chinese medicine mixture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] In this experiment, baicalin was extracted from Scutellaria baicalensis, a single qualified Chinese herbal medicine, by referring to the standard process of this mixture, in order to investigate the factors affecting the transfer rate of baicalin.

[0022] The standard process of this mixture is:

[0023] Take 180 parts of Chinese medicinal materials Rehmannia glutinosa, 160 parts of Ophiopogon japonicus, 260 parts of Scrophulariaceae, 315 parts of Forsythia and 315 parts of Scutellaria baicalensis, grind them into coarse powder, use 57% ethanol as solvent, soak for 24 hours, at a speed of about 1ml per minute Slowly percolate, collect about 6000ml of filtrate, recover ethanol under reduced pressure and concentrate to about 1400ml, add 800ml of water, boil for 30 minutes, let stand for 48 hours, filter, wash the filter residue with a small amount of water, add the lotion to the filtrate, reduce Concentrate under pressure to 1000ml, add 3g of sodium benzoate, stir well, ...

Embodiment 2

[0038] Embodiment 2: the investigation of the influence of temperature and pH value on the retention rate and relative density of baicalin in the mixture.

[0039] Get 1 / 2 prescription quantity medical material, carry out small test two batches by Pharmacopoeia process, to examine the impact of temperature, pH value on baicalin retention rate, relative density in the product process of the present invention.

[0040] Raw material: Rehmannia glutinosa 90g, Ophiopogon japonicus 80g, Scrophulariaceae 130g, Forsythia 157.5g and Scutellaria baicalensis 157.5g. The preparation process and results are shown in Table 2 and Table 3.

[0041] Table 2 Test Example 2 Preparation Technology and Results

[0042]

[0043]

[0044] Table 3 Test Example 3 process parameters and results

[0045]

[0046]

[0047] analyze

[0048] The percolation in the two experiments was carried out simultaneously, and the parameters of the compound recipe were verified mainly based on the exper...

Embodiment 3

[0051] Example 3: Investigation of the influence of alcohol precipitation conditions on relative density, pH value and baicalin of samples.

[0052] (1) Pre-test

[0053] Take two parts of QHY1 finished product (60ml each), add 95% ethanol to adjust the alcohol content to 70%, let it stand for 96 hours, recover the ethanol from the supernatant, then dilute it to 60ml with purified water, calculate and measure the relative density and pH Value, baicalin content, the results are shown in Table 4.

[0054] Table 4 Test Example 4 Result Table

[0055]

Room temperature (about 26°C)

Refrigerator (6°C)

Before alcohol precipitation (QHY1)

Relative density

1.07

1.06

1.21

Baicalin content

8.31

8.22

11.31

[0056] Result prompt:

[0057] 1. Alcohol precipitation with 70% ethanol can significantly reduce the relative density (<1.10), which proves that the relative density of the product can meet the statutory requirem...

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Abstract

The invention relates to a preparation method of Chinese medicine mixture containing scutellaria baicalensis, which solves the problems of uncertainty, low and unstable baicalin transferring rate and substandard quality in the existing standard preparation method. According to the preparation method, the scutellaria baicalensis is independently extracted to obtain baicalin on the basis of meeting the lawful process, and the technological parameters are further refined. Compared with the existing process, the preparation method can greatly improve the baicalin transferring rate and improve the product quality and the curative effect on the premise of ensuring all quality indexes of products to reach the standard, and the production process is simple in operation and the Chinese medicine mixture is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine mixture, in particular to a preparation method of a traditional Chinese medicine mixture comprising a scutellaria baicalensis extract. Background technique [0002] Scutellaria baicalensis is a commonly used clinical medicine in traditional Chinese medicine, derived from the root of Scutellaria baicalensis Georgi. There are heat-clearing and damp-drying, cooling blood and preventing miscarriage, detoxification effect. Indications for febrile disease, upper respiratory tract infection, lung-heat cough, damp-heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, restless fetus, high blood pressure, carbuncle, swollen boils and other diseases. The main active ingredients of Scutellaria baicalensis include baicalin, wogonin, baicalein, wogonin and other flavonoids, among which baicalin is the main active ingredient of scutellaria baicalensis, which has significant biologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/10A61P11/04A61P31/04
Inventor 洪丽萍徐吉银刘振民
Owner HAINAN HONZ PHARMA
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