Embolic material, and preparation method and use thereof

A technology of embolization and polymer materials, which is applied in the field of embolization materials and their preparation, and can solve problems such as errors

Active Publication Date: 2014-01-29
HYGEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is a certain error in this indirect judgment method

Method used

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  • Embolic material, and preparation method and use thereof
  • Embolic material, and preparation method and use thereof
  • Embolic material, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1 Preparation of embolic microparticles

[0094] In this embodiment, the drop method is used to prepare embolic microparticles, which includes the following steps:

[0095] 1) Prepare 1g sodium alginate into 0.005g / ml sodium alginate aqueous solution;

[0096] 2) Under stirring, drop the sodium alginate aqueous solution prepared in step 1) into the solution containing 50g of trivalent gadolinium ions (0.045g / ml). Obtain embolic microparticles.

Embodiment 2

[0097] Example 2 Preparation of embolic microparticles

[0098] In this embodiment, the drop method is used to prepare embolic microparticles, which includes the following steps:

[0099] 1) Prepare 1g of sodium alginate into a 0.01g / ml sodium alginate aqueous solution, add 5g of Pingyangmycin into the sodium alginate aqueous solution, and stir evenly to obtain a mixed solution (solution);

[0100] 2) Under stirring, drop the mixed liquid prepared in step 1) into the solution containing 1000g ferric ion (0.12g / ml), 1000g calcium ion (0.12g / ml) and 100g chitosan (0.012g / ml) In the solution, after the dripping is completed, continue to stir for 120 minutes to make the reaction fully, and obtain embolism particles after separation and washing;

[0101] 3) Soak the microparticles prepared in step 2) in a mixed solution containing 4g of formaldehyde and 1g of hydrochloric acid, conduct a cross-linking reaction for 24 hours, separate and wash to obtain embolic microparticles.

Embodiment 3

[0102] Example 3 Preparation of embolic microparticles

[0103] In this embodiment, the drop method is used to prepare embolic microparticles, which includes the following steps:

[0104] 1) Prepare 1g of sodium alginate into a 0.05g / ml sodium alginate aqueous solution, add 0.01g of tantalum powder into the sodium alginate aqueous solution, and stir evenly to obtain a mixed solution (suspension);

[0105] 2) Under stirring, drop the mixed liquid prepared in step 1) into the solution containing 23g of ferric ion (0.01g / ml) and 60g of chitosan (0.026g / ml), and continue stirring after the dripping is completed 120min to make the reaction fully, separate and wash the prepared particles;

[0106] 3) Soak the microparticles prepared in step 2) in a mixed solution containing 250g of formaldehyde and 150g of sulfuric acid, conduct a cross-linking reaction for 12 hours, separate and wash to obtain embolism microparticles.

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Abstract

The invention provides an embolic material, and a preparation method and use thereof. The embolic material is prepared from reactant materials; the reactant materials comprise 1 part by weight of sodium alga acid and more than 0.1 part by weight of magnetic metal ions, wherein a coordination compound is formed by the sodium alga acid and the magnetic metal ions. By adopting the embolic material disclosed by the invention, a doctor can directly monitor the position of an embolizing agent by magnetic resonance imaging (MRI) in and after embolization; the curative effect and the safety of embolotherapy are improved.

Description

technical field [0001] The invention belongs to the field of interventional medicine, and relates to an embolic material, a preparation method and application thereof. Background technique [0002] Interventional therapy is one of the fastest growing disciplines in the 21st century. At present, it has kept pace with medical treatment and surgical treatment, and has become the third treatment system. [0003] Embolization therapy is an important part of interventional therapy and belongs to minimally invasive therapy. Embolization therapy is a local treatment that artificially blocks blood vessels by introducing embolic agents into the human body through precision instruments such as special guide wires and catheters under the guidance of medical imaging equipment. Embolization therapy has a good effect in the treatment of malignant tumors, uterine fibroids, hemangiomas, vascular malformations and hemostasis, and has become an alternative to partial surgical treatment. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/02A61L31/18A61L31/16
Inventor 范田园周双卢晓静
Owner HYGEA MEDICAL TECH CO LTD
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