Portable sensing system and its functional modification method for early diagnosis of liver cancer

Abstract

The invention discloses a portable sensing system for early diagnosing liver cancer and functional modification method of the portable sensing system. The system comprises a micro cantilever array sensing unit, a surface modifying layer, an encapsulation shell, a driving module and a digital display interface processing circuit, wherein the micro cantilever array sensing unit is used for converting a mechanical signal of a cantilever into an electric signal and outputting the electric signal to a digital display interface processing circuit; the surface modifying layer grows on the surface of the micro cantilever array sensing unit and is used for functionalizing the surface of the micro cantilever array sensing unit so that the micro cantilever array sensing unit is capable of combining with a liver cancer landmark antigen specificity; the encapsulation shell is used for protecting the micro cantilever array sensing unit and providing a biochemical reaction sample inlet / outlet and a reaction chamber; the driving module is used for providing a resonant drive signal; and the digital display interface processing circuit is used for obtaining and outputting the liver cancer landmark quality according to the variation of resonant frequency of the micro cantilever. According to the system and method provided by the invention, the early screening of the liver cancer is possible, and the important significance is provided for early diagnosing and early treating the liver cancer and improving the survival rate of the liver rate.

Description

technical field [0001] The invention belongs to the fields of semiconductor, biochemistry and electricity, and in particular relates to a portable sensing system for early diagnosis of liver cancer and a functional modification method thereof. Background technique [0002] China is the largest country with liver cancer. At present, the incidence of liver cancer in my country accounts for about 55% of the world, ranking second only to lung cancer in tumor-related deaths. Early liver cancer (small liver cancer) often has no obvious symptoms. When the vast majority of liver cancer patients have symptoms such as liver pain, abdominal distension, abdominal mass, jaundice, and ascites, they have already reached the middle and late stages when they see a doctor, and they have lost the opportunity for surgery. Surgical resection rate is only 10%-30%. For unresectable cases, the effect of traditional radiotherapy and chemotherapy is not good, and the survival period of patients gener...

AI Technical Summary

Problems solved by technology

[0005] However, there are still some technical difficulties in the practical application of devices based on cantilever beam structures in the medical field, such as: measurement errors caused by non-specific adsorption on cantilever beams; large-area adsorption of antibodies and antigens on cantilever beams cause changes in beam elastic constants, resulting in frequency measurement error due to offset; and the cantilever beam quality factor is greatly reduced in the liquid biological environment of serum, resulting in a decrease in detection sensitivity

At present, the serological detection technology for major diseases used in hospitals is mainly large-scale equipment, which is expensive and time-consuming, and the diagnosis rate for early cancer is very low

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