Enteric-coated sustained release composition
A slow-release tablet and enteric-coating technology, which is applied in the field of enteric-coated slow-release compositions, paroxetine hydrochloride enteric-coated slow-release tablets and preparation fields, can solve problems such as drug instability, dissolution phenomenon, etc. The effect of short production time and long shelf life
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Embodiment 1
[0120] 25mg strength tablet
[0121] 1. Tablet Prescription:
[0122]
[0123] 2. Prescription of enteric coating solution:
[0124] Acryl-EZE appropriate amount
Appropriate amount of purified water
[0125] 3. Prescription of film coating solution:
[0126] Gastric-soluble film coating agent
Appropriate amount
Appropriate amount
[0127] Preparation:
[0128] 1. Prepare an adhesive of 10% PVP (50% w / w ethanol) for the drug-containing layer for use; the preparation method of the adhesive is as follows: 10 g of povidone K30 plus 90 g of 50% (w / w) ethanol.
[0129] 2. Prepare an adhesive of 25% PVP (50% w / w ethanol) for the retarding layer for use; the preparation method of the adhesive is as follows: 25 g of povidone K30 plus 75 g of 50% (w / w) ethanol
[0130] 3. Process of drug-containing layer: Weigh paroxetine hydrochloride, lactose, silicon dioxide and hypromellose K4M according to the prescripti...
Embodiment 2
[0145] 12.5mg strength tablet
[0146] 1. Tablets:
[0147]
[0148]
[0149] 2. Prescription of enteric coating solution:
[0150] Acryl-EZE appropriate amount
Appropriate amount of purified water
[0151] 3. Prescription of gastric soluble coating solution:
[0152] Gastric-soluble film coating agent
Appropriate amount
purified water
Appropriate amount
[0153] Prepared according to the method used in Example 1.
[0154] Examples 1 and 2 are industrial scale-up production, and 100,000 pieces are prepared.
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