Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Colon sigmoideum targeting empty capsule

A hollow capsule, sigmoid colon technology, applied in the directions of capsule delivery, medical preparations with non-active ingredients, pharmaceutical formulas, etc., can solve problems such as inability to deliver medicines directly

Active Publication Date: 2014-02-05
ANHUI HUANGSHAN CAPSULE CO LTD
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a hollow capsule that can disintegrate in the sigmoid colon, aiming at the defect that the existing colon-soluble hollow capsules cannot directly deliver the drug to the lesion site of the sigmoid colon. The technical problem to be solved is to select a suitable coating material, The coating material does not disintegrate in the colonic fluid of pH 7.8 but can disintegrate in the sigmoid fluid of pH 8.0

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Colon sigmoideum targeting empty capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Non-limiting examples are described as follows:

[0015] 1. Preparation of capsule material

[0016] Put gelatin or vegetable glue and water into the mixing tank, heat, stir and dissolve, then filter and adjust the specific gravity (that is, the concentration of the glue solution). Hyperdispersion. In addition, opacifying agent titanium dioxide and other auxiliary materials can also be added according to the user's needs, and the capsule material can be obtained by standing for heat preservation and removing air bubbles, and then putting it into the capsule production line, dipping the capsule cap body mold with glue, curing and drying.

[0017] 2. Coating

[0018] Use ethanol or / and acetone as a solvent, make ethyl cellulose into a 10% coating solution, coat at least once on the coating line, then dry, demould, cut, and fit to form a sigmoid colon target To empty capsules.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a colon sigmoideum targeting empty capsule. The colon sigmoideum targeting empty capsule comprises a capsule wall material made from gelatin or vegetable gelatin and a coating layer outside the capsule wall material and is characterized in that the coating layer is ethyecellulose, ferric oxide is contained in the capsule wall material, the colon sigmoideum targeting empty capsule comprises the following components in percentage by weight: 65%-75% of gelatin or vegetable glue, 20-30% of the ethyecellulose, and 3-5% of the ferric oxide. The colon sigmoideum targeting empty capsule does not disintegrate within two hours in gastric juice with the pH value of 2, cannot dissolve or disintegrate within 3 hours in intestinal juice with the pH value of 6.8, does not disintegrate within 1 hour in intestinal juice with the pH value of 7.8, disintegrates within 30 minutes in colon sigmoideum juice with the pH value of 8.0 and can rapidly reach a colon sigmoideum part under the guidance of an external magnetic field.

Description

1. Technical field [0001] The invention relates to an empty capsule as a pharmaceutical auxiliary material, in particular to an enteric-coated empty capsule, in particular to a targeted empty capsule that dissolves (disintegrates) at a specific human sigmoid colon site. 2. Background technology [0002] The end of the sigmoid colon is connected to the rectum, which is the most prone part of the colon in the human body. Therefore, delivering drugs directly to the sigmoid colon for release can effectively improve the bioavailability and curative effect of the drug. [0003] The empty capsules stipulated in the 2010 edition of "Chinese Pharmacopoeia" are divided into three types: stomach-soluble, enteric-coated and colon-soluble. The human small intestine (pH value 6.8) cannot dissolve or disintegrate within 3 hours, and the human colon (pH value 7.8) disintegrates within 1 hour. The human colon is composed of the ascending colon, transverse colon, descending colon and sigmoid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/04
Inventor 刘国攀刘松林
Owner ANHUI HUANGSHAN CAPSULE CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com