Preparation method of nano hydroxyapatite powder with controllable morphology

A nano-hydroxyapatite and morphology technology, applied in the field of biomedical materials, can solve the problems of cumbersome production process, long production cycle, and long aging time, and achieve good practical value, low cost, and shortened reaction time.

Active Publication Date: 2014-02-05
NORTH CHINA INST OF AEROSPACE ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, CN200610055171.X takes calcium nitrate and ammonium phosphate as raw materials, polymer compound polyvinylpyrrolidone as a template, and the pH value is controlled to be 10.5. Synthesizing nano-spherical hydroxyapatite nanocrystals with a particle size of 15-159nm, the method has a conditional process Simple, suitable for large-scale chemical industrial production, but the aging time is long, and it needs to be washed and washed, resulting in a long production cycle and cumbersome production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of precursor liquid A of Ca: at a concentration of 0.08mol / L Ca(NO 3 ) 2 4H 2 The additive amount in the O aqueous solution is 0.1wt% morphology control agent sodium polyacrylate; the precursor B liquid of P is prepared, and the calcium-phosphorus ratio n(Ca) / n(P) of making it and A liquid is 1.6; Liquid and B liquid mixed, while stirring with NH 3 ·H 2 O adjust the pH value of the solution to 8.5, keep the temperature of the solution at 20°C, and carry out coprecipitation reaction for 120 minutes; age the reaction liquid at room temperature for 20 hours; wash and separate the precipitate obtained and dry it at 60°C for 20 hours to obtain nano The powder of hydroxyapatite is rod-shaped by scanning electron microscope, with a length of about 300nm and an aspect ratio of about 7:1.

Embodiment 2

[0032] Preparation of precursor liquid A of Ca: at a concentration of 0.2mol / L Ca(NO 3 ) 2 4H 2 The additive amount in O aqueous solution is the morphology control agent sodium polyacrylate of 0.75wt%; Be prepared into the precursor B liquid of P, make it and the calcium phosphorus ratio n(Ca) / n(P) of A liquid be 1.67; A Liquid and B liquid mixed, while stirring with NH 3 ·H 2 O adjust the pH value of the solution to 8.5, keep the temperature of the solution at 37°C, and carry out coprecipitation reaction for 60 minutes; age the reaction liquid at room temperature for 20 hours; wash and separate the precipitate obtained and dry it at 60°C for 30 hours to obtain nano The hydroxyapatite powder is spherical in shape with a particle size of 300nm as shown by scanning electron microscopy.

Embodiment 3

[0034] Preparation of Ca precursor solution A: at a concentration of 0.18 mol / L Ca(NO 3 ) 2 4H 2 The additive amount in the O aqueous solution is 1.0wt% morphology control agent sodium polyacrylate; the precursor B liquid that is prepared into P: make it and the calcium phosphorus ratio n(Ca) / n(P) of A liquid be 1.70; A Liquid and B liquid mixed, while stirring with NH 3 ·H 2 O adjust the pH value of the solution to 10.5, keep the temperature of the solution at 50°C, and carry out coprecipitation reaction for 90 minutes; age the reaction liquid at room temperature for 40 hours; wash and separate the precipitate obtained and dry it at 50°C for 30 hours to obtain nano The powder of hydroxyapatite is flake by scanning electron microscope.

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PUM

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Abstract

The invention relates to the technical field of a preparation method of nano hydroxyapatite powder with a controllable morphology, and belongs to the scope of preparing nano hydroxyapatite powder with different morphologies by regulating an additive amount of a morphology regulator sodium polyacrylate and controlling coprecipitation synthesis conditions.

Description

technical field [0001] The invention relates to the preparation of nano-hydroxyapatite powder, in particular to a method for preparing nano-hydroxyapatite powder with controllable morphology, and belongs to the field of biomedical materials. Background technique [0002] Hydroxyapatite (hydroxyapatite, HA or HAP, molecular formula [Ca10(PO4)6(OH)2]) is the most representative and widely used bioactive ceramic, and it has good biocompatibility and Osteoconductive, showing excellent chemical and biological affinity with bone tissue, so it can be widely used in the repair, replacement and functional enhancement of biological hard tissues. Nano-HA has a large surface area and can be absorbed evenly by osteoclasts; in addition, it can also inhibit the proliferation of cancer cells. Its unique biochemical properties have attracted widespread attention in biomedical applications. [0003] Due to factors such as microstructure, size and morphology have a greater impact on the phys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor 孙艳荣马利国范涛李国洪
Owner NORTH CHINA INST OF AEROSPACE ENG
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