A method for preparing chitosan antibacterial nanospheres by jet self-excited pulse cavitation enhancement

A technology of nano-microspheres and chitosan, which is applied in botany equipment and methods, fungicides, chemicals for biological control, etc., and can solve the problems of difficult control of microsphere shape, particle size and dispersion, drug loading rate, etc. The problems of low mechanical strength and low mechanical strength of microspheres can achieve the effect of round shape, easy regulation and good dispersion

Active Publication Date: 2021-07-20
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical stirring operation adopted in this method is to realize the contact, dissolution and mixing between different liquids from a macroscopic point of view. The mixing process is inefficient, prone to dead angles, poor microscopic mass transfer effect, and high energy consumption in the process, which leads to the preparation of microscopic liquids. The spheres have defects such as low mechanical strength, low drug loading rate, uneven particle size distribution, and difficult control of microsphere shape, particle size and dispersion.

Method used

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  • A method for preparing chitosan antibacterial nanospheres by jet self-excited pulse cavitation enhancement
  • A method for preparing chitosan antibacterial nanospheres by jet self-excited pulse cavitation enhancement

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Embodiment 1

[0025] A method for preparing chitosan antibacterial nano-microspheres by jet self-excited pulse cavitation strengthening, comprising the following steps:

[0026] (1) Preparation of chitosan solution: Weigh 1.5 g of chitosan sample (molecular weight 50 kDa, degree of deacetylation 85%) and pour it into 1.0 L of formic acid solution (pH 2.16) with mass concentration of 1%. Stir until most of the solids are dissolved, let stand for 2.0 h to fully dissolve the chitosan, remove undissolved chitosan colloid and other impurities with a double-layer filter cloth, and prepare a chitosan solution with a mass concentration of 1.5g / L ;

[0027] (2) Preparation of anionic crosslinking agent solution: Weigh 1.5 g of sodium tripolyphosphate and dissolve it in 1.0 L of deionized water to prepare a sodium tripolyphosphate solution with a mass concentration of 1.5 g / L;

[0028] (3) Preparation of antibacterial agent solution: Weigh 0.58 g of methylisothiazolinone with a mass fraction of 10% ...

Embodiment 2

[0036] A method for preparing chitosan antibacterial nano-microspheres by jet self-excited pulse cavitation strengthening, comprising the following steps:

[0037] (1) Preparation of chitosan solution: Weigh 5.0 g of chitosan sample (molecular weight 90 kDa, degree of deacetylation 95%) and pour it into 1.0 L of citric acid solution with a mass concentration of 1% (pH 2.21) , stir until most of the solids are dissolved, let stand for 2.0 h, let the chitosan fully dissolve, remove the undissolved chitosan colloid and other impurities with a double-layer filter cloth, and prepare chitosan with a mass concentration of 5.0g / L solution;

[0038] (2) Preparation of anionic crosslinking agent solution: Weigh 3.5 g of sodium lauryl sulfate and dissolve it in 1.0 L of deionized water to prepare a sodium lauryl sulfate solution with a mass concentration of 3.5 g / L;

[0039] (3) Preparation of antibacterial agent solution: Weigh 1.15 g of methylisothiazolinone with a mass fraction of 10...

Embodiment 3

[0047] A method for preparing chitosan antibacterial nano-microspheres by jet self-excited pulse cavitation strengthening, comprising the following steps:

[0048] (1) Preparation of chitosan solution: Weigh 8.0 g of chitosan sample (molecular weight 80 kDa, degree of deacetylation 90%) and pour it into 1.0 L of acetic acid-sodium acetate buffer solution with a pH value of 3.6, and stir until large Part of the solid is dissolved, let stand for 2.0 h, let the chitosan fully dissolve, remove the undissolved chitosan colloid and other impurities with a double-layer filter cloth, and make a chitosan solution with a mass concentration of 8.0 g / L;

[0049] (2) Preparation of anionic crosslinking agent solution: Weigh 3.0 g of polyglutamic acid and dissolve it in 1.0 L of deionized water to prepare a polyglutamic acid solution with a mass concentration of 3.0 g / L;

[0050] (3) Preparation of antibacterial agent solution: Weigh 0.34 g of methylisothiazolinone with a mass fraction of 1...

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Abstract

The invention relates to a method for preparing chitosan antibacterial nano-microspheres by jet self-excited pulse cavitation strengthening, which comprises the following steps: (1) preparation of chitosan solution, (2) preparation of anion crosslinking agent solution, ( 3) Preparation of bacteriostatic agent solution, (4) Mixing of bacteriostatic agent and anionic cross-linking agent solution, (5) Jet self-excited pulse cavitation enhanced preparation of chitosan antibacterial nanospheres: chitosan, The mixed solution of the antibacterial agent and the anionic crosslinking agent is added to the jet self-excited pulse cavitation strengthening device, and the jet self-excited pulse cavitation strengthening device can generate self-excited oscillation and strong jet pulse cavitation device. The invention applies the cavitation effect produced by the self-excited pulse of the jet to the electrostatic adsorption crosslinking process between the chitosan solution and the anion crosslinking agent, so as to achieve the purpose of strengthening the preparation process of the chitosan nano microspheres; Low consumption, good repeatability, and easy process control.

Description

technical field [0001] The invention relates to a method for preparing chitosan antibacterial nanometer microspheres through jet self-excited pulse cavitation strengthening. Background technique [0002] As a natural polymer, chitosan is a positively charged chain polyamino weakly basic polysaccharide obtained after deacetylation of chitin. Because of its excellent biocompatibility, biodegradability and bioadhesion, and is safe and non-toxic, it is often processed into scaffolds, microspheres or nanomicroparticles in the fields of chemical industry, food, environmental protection, biology and medicine. In the form of balls, it is used as an active carrier to embed and load some valuable polypeptides, enzyme proteins, vitamins, amino acids, tea polyphenols, insulin and anticancer drugs. Therefore, the preparation of chitosan microspheres or nano-microspheres has always attracted the attention of the industry. [0003] At present, the preparation methods of chitosan microsph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/28A01N43/80A01N43/16A01P1/00A01P3/00
CPCA01N25/28A01N43/16A01N43/80
Inventor 张昆明黄永春徐云黄承都杨锋陆小菊任仙娥刘纯友艾硕左华江
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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