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Rapid detection device and method for whole blood platelet aggregation function

A platelet aggregation and detection device technology, applied in the field of laboratory medicine, can solve problems such as inability to adapt to large-scale sample detection, inability to detect platelet function, poor stability of detection results, etc. Detecting the effect of conditional standards

Active Publication Date: 2014-02-05
SINNOWA MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods generally have poor stability of test results, large blood volume, cumbersome operations, long time-consuming, high work intensity, or high cost of testing, which are difficult to be popularized in clinic.
In addition, the common deficiency of these methods is that they cannot adapt to the detection of large batches of samples.
Due to the defects and insufficiencies of the existing detection technology, the current platelet function test cannot be widely used in medical clinics, and it may also be an important reason for the serious harm of thrombotic diseases.

Method used

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  • Rapid detection device and method for whole blood platelet aggregation function
  • Rapid detection device and method for whole blood platelet aggregation function
  • Rapid detection device and method for whole blood platelet aggregation function

Examples

Experimental program
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Effect test

Embodiment 1

[0073] A rapid detection device for platelet aggregation function of whole blood, the device includes a detection chamber 1 and a sample tray 2 in the detection chamber 1, a detection unit 3, a driving device 4 and a heating device 5; a detection chamber cover is arranged on the top of the detection chamber , the sample loading plate 2 is connected with the driving device 4, the detection device 3 is composed of a photoelectric detector and a light source, the detection device 3 corresponds to the position of the detection tube, and a heating device 5 is arranged at the bottom of the detection cabin 1 (such as figure 1 shown);

[0074] The sample loading tray 2 is circular, and the periphery of the sample loading tray 2 is connected to 8 detection tube racks 7 through hooks 9. The detection tube racks are sealed at the bottom, open at the top, and hollowed out on the side wall. The inner cavity is a cylindrical structure (such as image 3As shown), hanging rods 8 are set at bo...

Embodiment 2

[0077] A rapid detection device for platelet aggregation function of whole blood, the device includes a detection chamber 1 and a sample tray 2 in the detection chamber 1, a detection unit 3, a driving device 4 and a heating device 5; a detection chamber cover is arranged on the top of the detection chamber , the sample loading plate 2 is connected with the driving device 4, the detection device 3 is composed of a photoelectric detector and a light source, the detection device 3 is corresponding to the mounting of the detection tube, and a heating device (such as figure 1 shown);

[0078] The sample loading tray 2 is circular, and the periphery of the sample loading tray 2 is connected to 8 detection tube racks 7 through hooks. The detection tube racks are sealed at the bottom, open at the top, and hollowed out on the side wall. The inner cavity is a square column structure (such as Figure 4 As shown), hanging rods are set at both ends close to the top position, and the h...

Embodiment 3

[0100] A rapid detection device for platelet aggregation function of whole blood, the device includes a detection chamber 1 and a sample tray 2 in the detection chamber 1, a detection unit 3, a driving device 4 and a heating device 5; a detection chamber cover is arranged on the top of the detection chamber , the sample loading plate 2 is connected with the driving device 4, the detection device 3 is composed of a photoelectric detector and a light source, the detection device 3 corresponds to the position of the detection tube, and a heating device is arranged at the bottom of the detection cabin 1;

[0101] The sample loading tray 2 is circular, and the circumference of the sample loading tray 2 is connected to 8 detection tube racks 7 through hooks. The detection tube racks are sealed at the bottom, open at the top, and hollowed out on the side wall. The inner cavity is a square cylindrical structure (such as Figure 4 As shown), hanging rods are set at both ends close to th...

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Abstract

The invention discloses a rapid detection device and method for a whole blood platelet aggregation function. The rapid detection device comprises a detection bin, a sample carrying disc, a detection unit, a drive device, and a heating device, wherein the sample carrying disc, the detection unit, the drive device and the heating device are arranged in the detection bin. A red blood cell, white blood cell and platelet aggregation complex is settled on the bottom of a detection pipe by using low-speed centrifugation, blood platelet monomers which are not aggregated are remained in supernate (blood plasma) without settling, and then, the supernate is irradiated by directly using visible light; because the blood platelet can absorb and scatter visible light, and the absorption and the scattering of the blood platelet to the light is related to the concentration of the platelet when the blood platelet with same volumes is irradiated within a specific wavelength. Through detecting a transmission light signal of the supernate when being irradiated within the specific wavelength and detecting the intensity of scattering light, and respectively comparing with transmission light or scattering light signals of corresponding contrast pipes, the content of the blood platelet in the supernate can be detected, and the aggregation rate of the blood platelet can be figured out, and thus the aggregation function level of the blood platelet in a sample is reflected.

Description

technical field [0001] The invention relates to the field of laboratory medicine, in particular to a rapid whole blood platelet aggregation function detection device and method using whole blood as a sample. Background technique [0002] Thrombotic disease refers to the general term for various diseases such as myocardial infarction and cerebral infarction caused by blood embolism. According to the data released by international and Chinese health organizations, the death rate caused by thrombosis has long occupied the first place among all causes of death. Thrombosis has the characteristics of high mortality, high morbidity, high recurrence rate, and high disability rate. The most serious disease to human health and life. [0003] Platelets are an important component of blood coagulation and hemostasis. Long-term laboratory research and clinical practice have confirmed that: platelets are the first and key factor in thrombus formation; antiplatelet drugs are key measures...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/00G01N21/59G01N21/47
Inventor 徐新周强朱建波张陆军宋成桥
Owner SINNOWA MEDICAL SCI & TECH
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